Filtered By:
Source: Viruses

This page shows you your search results in order of date. This is page number 20.

Order by Relevance | Date

Total 1003 results found since Jan 2013.

Viruses, Vol. 14, Pages 2180: Pin-Pointing the Key Hubs in the IFN- & gamma; Pathway Responding to SARS-CoV-2 Infection
Viruses, Vol. 14, Pages 2180: Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection Viruses doi: 10.3390/v14102180 Authors: Ayelen Toro Sofia Lage-Vickers Juan Bizzotto Felipe Vilicich Agustina Sabater Gaston Pascual Sabrina Ledesma-Bazan Pablo Sanchis Maria Sol Ruiz Ana Paula Arevalo Jorge L. Porfido Mercedes Abbate Rocio Seniuk Estefania Labanca Nicolas Anselmino Nora M. Navone Daniel F. Alonso Elba Vazquez Martina Crispo Javier Cotignola Geraldine Gueron Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for...
Source: Viruses - September 30, 2022 Category: Virology Authors: Ayelen Toro Sofia Lage-Vickers Juan Bizzotto Felipe Vilicich Agustina Sabater Gaston Pascual Sabrina Ledesma-Bazan Pablo Sanchis Maria Sol Ruiz Ana Paula Arevalo Jorge L. Porfido Mercedes Abbate Rocio Seniuk Estefania Labanca Nicolas Anselmino Nora M. Nav Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2155: Monkeypox: A Comprehensive Review
Firzan Nainu Malik Sallam The 2022 multi-country monkeypox outbreak in humans has brought new public health adversity on top of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The disease has spread to 104 countries throughout six continents of the world, with the highest burden in North America and Europe. The etiologic agent, monkeypox virus (MPXV), has been known since 1959 after isolation from infected monkeys, and virulence among humans has been reported since the 1970s, mainly in endemic countries in West and Central Africa. However, the disease has re-emerged in 2022 at an unprecedented pace, with pa...
Source: Viruses - September 29, 2022 Category: Virology Authors: Harapan Harapan Youdiil Ophinni Dewi Megawati Andri Frediansyah Sukamto S. Mamada Mirnawati Salampe Talha Bin Emran Wira Winardi Raisha Fathima Salin Sirinam Pichamon Sittikul Ana M. Stoian Firzan Nainu Malik Sallam Tags: Review Source Type: research

Viruses, Vol. 14, Pages 2149: Evaluation of Cardiac Biomarkers and Expression Analysis of IL-1, IL-6, IL-10, IL-17, and IL-25 among COVID-19 Patients from Pakistan
Guixue Wang Coronavirus disease 19 (COVID-19) is caused by viral infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Where upregulation of several important biomarkers and multiple organ dysfunction occurs, this study aimed to evaluate the association of cardiac biomarkers and CS induced acute lung damage with disease severity and mortality in survival of COVID-19 patients. A total of 500 COVID-19 patients with elevated cardiac biomarkers were studied for the analysis of myocardial abnormality through cardiac enzymes, inflammatory biomarkers, and the expression analysis of various cytokines, incl...
Source: Viruses - September 29, 2022 Category: Virology Authors: Razi Ullah Jadoon Khan Nosheen Basharat Danqun Huo Ahmad Ud Din Guixue Wang Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2143: New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination
si Xu Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak and COVID-19 vaccination, new-onset and relapsed clinical cases of membranous nephropathy (MN) have been reported. However, their clinical characteristics and pathogenesis remained unclear. In this article, we collected five cases of MN associated with SARS-CoV-2 infection and 37 related to COVID-19 vaccination. Of these five cases, four (4/5, 80%) had acute kidney injury (AKI) at disease onset. Phospholipase A2 receptor (PLA2R) in kidney tissue was negative in three (3/5, 60%) patients, and no deposition of virus particles was measur...
Source: Viruses - September 28, 2022 Category: Virology Authors: Qiqi Ma Xiang Li Gaosi Xu Tags: Review Source Type: research

Viruses, Vol. 14, Pages 2125: Recent Emergence of Bovine Coronavirus Variants with Mutations in the Hemagglutinin-Esterase Receptor Binding Domain in U.S. Cattle
in M. Hause Bovine coronavirus (BCoV) has spilled over to many species, including humans, where the host range variant coronavirus OC43 is endemic. The balance of the opposing activities of the surface spike (S) and hemagglutinin-esterase (HE) glycoproteins controls BCoV avidity, which is critical for interspecies transmission and host adaptation. Here, 78 genomes were sequenced directly from clinical samples collected between 2013 and 2022 from cattle in 12 states, primarily in the Midwestern U.S. Relatively little genetic diversity was observed, with genomes having >98% nucleotide identity. Eleven isolates...
Source: Viruses - September 27, 2022 Category: Virology Authors: Aspen M. Workman Tara G. McDaneld Gregory P. Harhay Subha Das John Dustin Loy Benjamin M. Hause Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2126: Lessons Learned from the COVID-19 Pandemic and How Blood Operators Can Prepare for the Next Pandemic
en Humans interact with virus-infected animal hosts, travel globally, and maintain social networks that allow for novel viruses to emerge and develop pandemic potential. There are key lessons-learned from the coronavirus diseases 2019 (COVID-19) pandemic that blood operators can apply to the next pandemic. Warning signals to the COVID-19 pandemic included outbreaks of Severe acute respiratory syndrome-related coronavirus-1 (SARS-CoV-1) and Middle East respiratory syndrome-related coronavirus (MERS-CoV) in the prior two decades. It will be critical to quickly determine whether there is a risk of blood-borne transmission...
Source: Viruses - September 27, 2022 Category: Virology Authors: Steven J. Drews Sheila F. O ’Brien Tags: Review Source Type: research

Viruses, Vol. 14, Pages 2114: Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and Districts
Selzer Thorsten Lehr The coronavirus disease 2019 (COVID-19) pandemic challenged many national health care systems, with hospitals reaching capacity limits of intensive care units (ICU). Thus, the estimation of acute local burden of ICUs is critical for appropriate management of health care resources. In this work, we applied non-linear mixed effects modeling to develop an epidemiological SARS-CoV-2 infection model for Germany, with its 16 federal states and 400 districts, that describes infections as well as COVID-19 inpatients, ICU patients with and without mechanical ventilation, recoveries, and fatalities during...
Source: Viruses - September 24, 2022 Category: Virology Authors: Christiane Dings Katharina Martha G ötz Katharina Och Iryna Sihinevich Quirin Werthner Sigrun Smola Marc Bliem Felix Mahfoud Thomas Volk Sascha Kreuer J ürgen Rissland Dominik Selzer Thorsten Lehr Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2089: Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding
ndi The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and eradicate this pathogen. SARS-CoV-2 has four structural proteins: Envelope (E), Membrane (M), Nucleocapsid (N), and Spike (S), which self-assemble along with its RNA into the infectious virus by budding from intracellular lipid membranes. In this paper, we develop a model to explore the mechanisms of RNA condensation by structural proteins, protein oligomerization and cellular membrane–protein interactions that control the budding pr...
Source: Viruses - September 20, 2022 Category: Virology Authors: Siyu Li Roya Zandi Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2086: COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness
guyen The efficacy of vaccines against coronavirus disease 2019 (COVID-19) has now been well established in phase III clinical trials. However, clinical studies based on real-world data remain critical to assess vaccines effectiveness (VE), especially in specific populations and against variants of concern (VOC). This review presents the principles and methods of VE studies and the main available results on VE of COVID-19 vaccines at the time of Omicron circulation. References for this narrative review were identified through searches of PubMed database up to 13 September 2022. The results of phase III clinical trials ...
Source: Viruses - September 20, 2022 Category: Virology Authors: Yousra Kherabi Odile Launay Liem Binh Luong Luong Nguyen Tags: Review Source Type: research

Viruses, Vol. 14, Pages 2075: Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor
an Li Jin Zhang The ongoing spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused hundreds of millions of cases and millions of victims worldwide with serious consequences to global health and economies. Although many vaccines protecting against SARS-CoV-2 are currently available, constantly emerging new variants necessitate the development of alternative strategies for prevention and treatment of COVID-19. Inhibitors that target the main protease (Mpro) of SARS-CoV-2, an essential enzyme that promotes viral maturation, represent a key class of antivirals. Here, we showed that a peptidomim...
Source: Viruses - September 18, 2022 Category: Virology Authors: Xiaohui Hu Cheng Lin Qin Xu Xuelan Zhou Pei Zeng Peter J. McCormick Haihai Jiang Jian Li Jin Zhang Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2055: Chemically Modified Bovine & beta;-Lactoglobulin as a Broad-Spectrum Influenza Virus Entry Inhibitor with the Potential to Combat Influenza Outbreaks
Viruses, Vol. 14, Pages 2055: Chemically Modified Bovine β-Lactoglobulin as a Broad-Spectrum Influenza Virus Entry Inhibitor with the Potential to Combat Influenza Outbreaks Viruses doi: 10.3390/v14092055 Authors: Yuhong Fu Peiyu Li Wei Xu Zezhong Liu Cong Wang Qian Wang Jiayi Tang Weihua Li Lu Lu Shibo Jiang Frequent outbreaks of the highly pathogenic influenza A virus (AIV) infection, together with the lack of broad-spectrum influenza vaccines, call for the development of broad-spectrum prophylactic agents. Previously, 3-hydroxyphthalic anhydride-modified bovine β-lactoglob...
Source: Viruses - September 16, 2022 Category: Virology Authors: Yuhong Fu Peiyu Li Wei Xu Zezhong Liu Cong Wang Qian Wang Jiayi Tang Weihua Li Lu Lu Shibo Jiang Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2044: Small GTPase-a Key Role in Host Cell for Coronavirus Infection and a Potential Target for Coronavirus Vaccine Adjuvant Discovery
Haidong Wang Small GTPases are signaling molecules in regulating key cellular processes (e.g., cell differentiation, proliferation, and motility) as well as subcellular events (e.g., vesicle trafficking), making them key participants, especially in a great array of coronavirus infection processes. In this review, we discuss the role of small GTPases in the coronavirus life cycle, especially pre-entry, endocytosis, intracellular traffic, replication, and egress from the host cell. Furthermore, we also suggest the molecules that have potent adjuvant activity by targeting small GTPases. These studies provide deep insight...
Source: Viruses - September 14, 2022 Category: Virology Authors: Wei Hou Sibei Wang Heqiong Wu Linli Xue Bin Wang Shouyu Wang Haidong Wang Tags: Review Source Type: research

Viruses, Vol. 14, Pages 2041: Cross-Reactivity of SARS-CoV-2 Nucleocapsid-Binding Antibodies and Its Implication for COVID-19 Serology Tests
ova-Sivak The emergence of the new coronavirus SARS-CoV-2 in late 2019 led to the global pandemic COVID-19, causing a profound socioeconomic crisis. Adequate diagnostic tools need to be developed to control the ongoing spread of infection. Virus-specific humoral immunity in COVID-19 patients and those vaccinated with specific vaccines has been characterized in numerous studies, mainly using Spike protein-based serology tests. However, Spike protein and specifically its receptor-binding domain (RBD) are mutation-prone, suggesting the reduced sensitivity of the validated serology tests in detecting antibodies raised to v...
Source: Viruses - September 14, 2022 Category: Virology Authors: Alexandra Rak Svetlana Donina Yana Zabrodskaya Larisa Rudenko Irina Isakova-Sivak Tags: Brief Report Source Type: research

Viruses, Vol. 14, Pages 2038: Evaluation of UVC Excimer Lamp (222 nm) Efficacy for Coronavirus Inactivation in an Animal Model
eggio Michele Drigo The current pandemic caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has encouraged the evaluation of novel instruments for disinfection and lowering infectious pressure. Ultraviolet subtype C (UVC) excimer lamps with 222 nm wavelength have been tested on airborne pathogens on surfaces and the exposure to this wavelength has been considered safer than conventional UVC. To test the efficacy of UVC excimer lamps on coronaviruses, an animal model mimicking the infection dynamics was implemented. An attenuated vaccine based on infectious bronchitis virus (IBV) was nebuli...
Source: Viruses - September 14, 2022 Category: Virology Authors: Claudia Maria Tucciarone Mattia Cecchinato Lucrezia Vianello Gabriele Simi Enrico Borsato Luca Silvestrin Michele Giorato Cristiano Salata Mauro Morandin Elisa Greggio Michele Drigo Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2040: Clinical Follow-Up and Postmortem Findings in a Cat That Was Cured of Feline Infectious Peritonitis with an Oral Antiviral Drug Containing GS-441524
iasek Katrin Hartmann This is the first report on a clinical follow-up and postmortem examination of a cat that had been cured of feline infectious peritonitis (FIP) with ocular manifestation by successful treatment with an oral multicomponent drug containing GS-441524. The cat was 6 months old when clinical signs (recurrent fever, lethargy, lack of appetite, and fulminant anterior uveitis) appeared. FIP was diagnosed by ocular tissue immunohistochemistry after enucleation of the affected eye. The cat was a participant in a FIP treatment study, which was published recently. However, 240 days after leaving the clinic ...
Source: Viruses - September 14, 2022 Category: Virology Authors: Daniela Krentz Katharina Zwicklbauer Sandra Felten Mich èle Bergmann Roswitha Dorsch Regina Hofmann-Lehmann Marina L. Meli Andrea M. Spiri Ulrich von Both Martin Alberer Anne H önl Kaspar Matiasek Katrin Hartmann Tags: Case Report Source Type: research