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Viruses, Vol. 14, Pages 2271: Development of Single-Cell Transcriptomics and Its Application in COVID-19
This article reviewed the use of single-cell transcriptomics in COVID-19 research, examined the immune response disparities generated by SARS-CoV-2, and offered insights regarding how to improve COVID-19 diagnosis and treatment plans.
Source: Viruses - October 16, 2022 Category: Virology Authors: Chaochao Wang Ting Huyan Xiaojie Zhou Xuanshuo Zhang Suyang Duan Shan Gao Shanfeng Jiang Qi Li Tags: Review Source Type: research

Viruses, Vol. 14, Pages 2270: Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric Disorders
rou Coronavirus Disease 2019 (COVID-19) is associated with increased incidence of neurological diseases and neuropsychiatric disorders after infection, but how it contributes to their development remains under investigation. Here, we investigate the possible relationship between COVID-19 and the development of ten neurological disorders and three neuropsychiatric disorders by exploring two pathological mechanisms: (i) dysregulation of host biological processes via virus–host protein–protein interactions (PPIs), and (ii) autoreactivity of severe acute respiratory syndrome coronavirus 2 (SARS-...
Source: Viruses - October 16, 2022 Category: Virology Authors: Anna Onisiforou George M. Spyrou Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2261: Small-Molecule RAF265 as an Antiviral Therapy Acts against PEDV Infection
Xiao-Jia Wang Porcine epidemic diarrhea virus (PEDV), a member of the family Coronaviridae, causes acute diarrhea, vomiting, dehydration, and high mortality in newborn piglets, and has caused significant economic losses in the pig industry. There are currently no specific drugs available to treat PEDV. Viruses depend exclusively on the cellular machinery to ensure an efficient replication cycle. In the present study, we found that small-molecule RAF265, an anticancer drug that has been shown to be a potent inhibitor of RAF, reduced viral loads of PEDV by 4 orders of magnitude in Vero cells, and protected piglets from v...
Source: Viruses - October 15, 2022 Category: Virology Authors: Jing Wang Wen-Jun Tian Cui-Cui Li Xiu-Zhong Zhang Kai Fan Song-Li Li Xiao-Jia Wang Tags: Communication Source Type: research

Viruses, Vol. 14, Pages 2259: Pre-Pandemic Cross & #8209;Reactive Immunity against SARS-CoV-2 among Central and West African Populations
In conclusion, our results suggest that, in the investigated African sub-regions, the tested populations could have been potentially and partially pre-exposed, before the COVID-19 pandemic, to the antigens of a yet non-identified Coronaviruses.
Source: Viruses - October 14, 2022 Category: Virology Authors: Marc Souris L éon Tshilolo Daniel Parzy Line Lobaloba Ingoba Francine Ntoumi Rachel Kamgaing Moussa Ndour Destin Mbongi Balthazar Phoba Marie-Anasthasie Tshilolo Ren é Mbungu Martin Samuel Sosso Nadine Fainguem Tandakha Ndiaye Dieye Massamba Sylla Pierr Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2257: Antiviral Activity of Ficus rubiginosa Leaf Extracts against HSV-1, HCoV-229E and PV-1
ico Vittorio Delfino Ficus rubiginosa plant extract showed antimicrobial activity, but no evidence concerning its antiviral properties was reported. The antiviral activity of the methanolic extract (MeOH) and its n-hexane (H) and ethyl acetate (EA) fractions against Herpes simplex virus-1 (HSV-1), Human coronavirus (HCoV) -229E, and Poliovirus-1 (PV-1) was investigated in the different phases of viral infection in the VERO CCL-81 cell line. To confirm the antiviral efficacy, a qPCR was conducted. The recorded cytotoxic concentration 50% was 513.1, 298.6, and 56.45 µg/mL for MeOH, H, and EA, respectively, ...
Source: Viruses - October 14, 2022 Category: Virology Authors: Federica Dell ’Annunziata Carmine Sellitto Gianluigi Franci Maria Carla Marcotullio Anna Piovan Roberta Della Marca Veronica Folliero Massimiliano Galdiero Amelia Filippelli Valeria Conti Domenico Vittorio Delfino Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2255: Rhabdomyolysis after COVID-19 Infection: A Case Report and Review of the Literature
Ali Abbara Rhabdomyolysis is a condition in which muscle breaks down potentially leading to renal dysfunction, and often occurs secondary to a precipitating factor. Viral or bacterial infections are common precipitants for initiating rhabdomyolysis. Recently, healthcare systems across the world have been challenged by a pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing ‘coronavirus disease 2019’ (COVID-19) disease. SARS-CoV-2 infection is recognized to cause respiratory and cardiovascular compromise, thromboembolic events, and acute kidney injury (AKI); howeve...
Source: Viruses - October 14, 2022 Category: Virology Authors: Monica Bawor Shwetha Sairam Rachel Rozewicz Stuart Viegas Alexander N. Comninos Ali Abbara Tags: Case Report Source Type: research

Viruses, Vol. 14, Pages 2259: Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African Populations
In conclusion, our results suggest that, in the investigated African sub-regions, the tested populations could have been potentially and partially pre-exposed, before the COVID-19 pandemic, to the antigens of a yet non-identified Coronaviruses.
Source: Viruses - October 14, 2022 Category: Virology Authors: Marc Souris L éon Tshilolo Daniel Parzy Line Lobaloba Ingoba Francine Ntoumi Rachel Kamgaing Moussa Ndour Destin Mbongi Balthazar Phoba Marie-Anasthasie Tshilolo Ren é Mbungu Martin Samuel Sosso Nadine Fainguem Tandakha Ndiaye Dieye Massamba Sylla Pierr Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2233: Performing under Pressure: Insights into the Diagnostic Testing Burden at a UK National Health Service Clinical Virology Laboratory during the SARS-CoV-2 Pandemic
This report details the virology test requests received by the Leicester-based NHS Virology laboratory from January 2018 to May 2022. Data show that in spite of a dramatic increase in screening, along with multiple logistic and staffing issues, the Leicester Virology Department was mostly able to maintain the same level of service for non-respiratory virus testing while meeting the new increase in SARS-CoV-2 testing.
Source: Viruses - October 12, 2022 Category: Virology Authors: Paul William Bird Georgina Taylor Jessica Cafferata Judi Gardener Claire L. McMurray Oliver Fletcher Oliver T. R. Toovey Christopher W. Holmes Julian W. Tang Tags: Brief Report Source Type: research

Viruses, Vol. 14, Pages 2232: The Relative Roles of Ambient Temperature and Mobility Patterns in Shaping the Transmission Heterogeneity of SARS-CoV-2 in Japan
Saito We assess the effects of ambient temperature and mobility patterns on the transmissibility of COVID-19 during the epidemiological years of the pandemic in Japan. The prefecture-specific daily time-series of confirmed coronavirus disease 2019 (COVID-19) cases, meteorological variables, levels of retail and recreation mobility (e.g., activities, going to restaurants, cafes, and shopping centers), and the number of vaccinations were collected for six prefectures in Japan from 1 May 2020 to 31 March 2022. We combined standard time-series generalized additive models (GAMs) with a distributed lag non-linear model (DLNM...
Source: Viruses - October 11, 2022 Category: Virology Authors: Keita Wagatsuma Iain S. Koolhof Reiko Saito Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2217: A Review of Bioactive Compounds against Porcine Enteric Coronaviruses
This study will be also helpful in discovering general host factors that affect the replication of CoVs and provide references for the prevention and treatment of other CoVs.
Source: Viruses - October 8, 2022 Category: Virology Authors: Cong Duan Yufeng Luo Xianming Liang Xia Wang Tags: Review Source Type: research

Viruses, Vol. 14, Pages 2205: Catching the Wave: Detecting Strain-Specific SARS-CoV-2 Peptides in Clinical Samples Collected during Infection Waves from Diverse Geographical Locations
In this study, we developed an accessible, flexible, and shareable bioinformatics workflow that was implemented in the Galaxy Platform to detect variant-specific peptide sequences from MS data derived from the clinical samples. We demonstrated the utility of the workflow by characterizing published clinical data from across the world during various pandemic waves. Our analysis identified six SARS-CoV-2 variant-specific peptides suitable for confident detection by MS in commonly collected clinical samples.
Source: Viruses - October 7, 2022 Category: Virology Authors: Subina Mehta Valdemir M. Carvalho Andrew T. Rajczewski Olivier Pible Bj örn A. Grüning James E. Johnson Reid Wagner Jean Armengaud Timothy J. Griffin Pratik D. Jagtap Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2202: A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
In conclusion, we have identified a novel broad spectrum antiviral inhibitor that efficiently targets a broad range of RNA viruses.
Source: Viruses - October 6, 2022 Category: Virology Authors: Richard Lindqvist Caroline Benz Vita Sereikaite Lars Maassen Louise Laursen Per Jemth Kristian Str ømgaard Ylva Ivarsson Anna K. Överby Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2196: The Performances of Three Commercially Available Assays for the Detection of SARS-CoV-2 Antibodies at Different Time Points Following SARS-CoV-2 Infection
jørn Blomberg Mai Chi Trieu Nina Langeland Rebecca Jane Cox The aim of this study was to evaluate the performances of three commercially available antibody assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at different time points following SARS-CoV-2 infection. Sera from 536 cases, including 207 SARS-CoV-2 PCR positive, were tested for SARS-CoV-2 antibodies with the Wantai receptor binding domain (RBD) total antibody assay, Liaison S1/S2 IgG assay and Alinity i nucleocapsid IgG assay and compared to a two-step reference ELISA (SARS-CoV-2 RBD IgG and SARS-CoV-2 s...
Source: Viruses - October 5, 2022 Category: Virology Authors: Heidi Syre Marius Eduardo Br å Obreque Ingvild Dalen Åse Garløv Riis Åse Berg Iren H øyland Löhr Jon Sundal Lars K åre Kleppe May Sissel Vadla Ole Bernt Lenning Jan Stefan Olofsson Kristin Greve-Isdahl Mohn Camilla T øndel Bj ørn Blomberg Mai Chi Tags: Article Source Type: research

Viruses, Vol. 14, Pages 2182: Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19
In this study, we evaluated the upper respiratory tract host transcriptional response in COVID-19 patients with mild to severe symptoms and compared it with the control COVID-19 negative group using RNA-sequencing (RNA-Seq). Our results reveal an upregulated early type I interferon response in severe COVID-19 patients as compared to mild or negative COVID-19 patients. Moreover, severely symptomatic patients have pronounced induction of interferon stimulated genes (ISGs), particularly the oligoadenylate synthetase (OAS) family of genes. Our results are in concurrence with other studies depicting the early induction of IFN-I...
Source: Viruses - October 1, 2022 Category: Virology Authors: Shabir A. Bhat Tomohiro Shibata Matthew Leong Jasmine Plummer Eric Vail Zakir Khan Tags: Brief Report Source Type: research

Viruses, Vol. 14, Pages 2162: Clinical Characteristics of Coronavirus Disease (COVID-19) in Mexican Children and Adolescents
Conclusion: During the first 2 years of the COVID-19 pandemic in Mexico, children and adolescents had low incidence and mortality. They are a heterogeneous population, but many patients had comorbidities such as obesity, asthma, and immunosuppression; symptoms such as fever, cough, and headache; and low viral load and IgG antibodies.
Source: Viruses - September 30, 2022 Category: Virology Authors: Alejandro Flores-Alanis Zeus Salda ña-Ahuactzi Israel Parra-Ortega Pablo L ópez-Ramírez Marcela Salazar-Garc ía Yolanda P. Alem án-García Armando Cruz-Rangel Alba Moreno-Paredes Adri án Diaz-Rojas Carmen Maldonado-Bernal Jessica Quevedo-Moran Victo Tags: Article Source Type: research