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Total 1003 results found since Jan 2013.

Viruses, Vol. 15, Pages 614: Rational Use of Monoclonal Antibodies as Therapeutic Treatment in an Oncologic Patient with Long COVID
This study highlights the Evusheld monoclonal antibodies’ efficacy, not only in prevention but also in successful therapy against prolonged COVID-19. Therefore, testing neutralizing monoclonal antibodies in vitro against SARS-CoV-2 mutants directly isolated from patients could provide useful information for the treatment of people affected by long COVID.
Source: Viruses - February 23, 2023 Category: Virology Authors: Maria Grazia Cusi Anna Maria Di Giacomo Gabriele Anichini Gianni Gori Savellini Chiara Terrosi Claudia Gandolfo Michele Maio Tags: Case Report Source Type: research

Viruses, Vol. 15, Pages 600: COVID-19 and Heart Failure with Preserved and Reduced Ejection Fraction Clinical Outcomes among Hospitalized Patients in the United States
khar Abu Baker Sheikh Heart failure exacerbations impart significant morbidity and mortality, however, large- scale studies assessing outcomes in the setting of concurrent coronavirus disease-19 (COVID-19) are limited. We utilized National Inpatient Sample (NIS) database to compare clinical outcomes in patients admitted with acute congestive heart failure exacerbation (CHF) with and without COVID-19 infection. A total of 2,101,980 patients (Acute CHF without COVID-19 (n = 2,026,765 (96.4%) and acute CHF with COVID-19 (n = 75,215, 3.6%)) were identified. Multivariate logistic regression analysis was utilized to compar...
Source: Viruses - February 22, 2023 Category: Virology Authors: Adeel Nasrullah Karthik Gangu Harmon R. Cannon Umair A. Khan Nichole B. Shumway Aneish Bobba Shazib Sagheer Prabal Chourasia Hina Shuja Sindhu Reddy Avula Rahul Shekhar Abu Baker Sheikh Tags: Article Source Type: research

Viruses, Vol. 15, Pages 596: Biomimetic Nanotechnology for SARS-CoV-2 Treatment
hao Liu More than 600 million people worldwide have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in the pandemic of coronavirus disease 2019 (COVID-19). In particular, new waves of COVID-19 caused by emerging SARS-CoV-2 variants pose new health risks to the global population. Nanotechnology has developed excellent solutions to combat the virus pandemic, such as ACE2-based nanodecoys, nanobodies, nanovaccines, and drug nanocarriers. Lessons learned and strategies developed during this battle against SARS-CoV-2 variants may also serve as inspiration for developing nanotechnol...
Source: Viruses - February 21, 2023 Category: Virology Authors: Shuo Li Xue Liu Gang Liu Chao Liu Tags: Review Source Type: research

Viruses, Vol. 15, Pages 585: Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil
In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions i...
Source: Viruses - February 20, 2023 Category: Virology Authors: Mariane Talon de Menezes Filipe Romero Rebello Moreira Charles Whittaker Franciele Martins Santos Daniel Costa Queiroz Victor Geddes Paula Luize Camargos Fonseca Jaqueline G óes de Jesus Franciane Mendes-Oliveira Valqu íria Reis-Souza Bibiana Santos Dan Tags: Article Source Type: research

Viruses, Vol. 15, Pages 582: Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea
ik Peiris Julia A. Beatty Vanessa R. Barrs Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide since its emergence in 2019. Knowing the potential capacity of the virus to adapt to other species, the serological surveillance of SARS-CoV-2 infection in susceptible animals is important. Hong Kong and Seoul are two of Asia’s most densely populated urban cities, where companion animals often live in close contact with humans. Sera collected from 1040 cats and 855 dogs during the early phase of the pandemic in Hong Kong and Seoul were tested for SARS-CoV-2 ...
Source: Viruses - February 20, 2023 Category: Virology Authors: Yun Young Go Maura Carrai Yan Ru Choi Christopher J. Brackman Karina W. S. Tam Pierra Y. T. Law Fiona Woodhouse Jane Gray Ji Hun Kim Joohyung Park Chae Won Jeon Hyomi Jang Ioannis Magouras Nicola Decaro Samuel M.S. Cheng Malik Peiris Julia A. Beatty Vanes Tags: Communication Source Type: research

Viruses, Vol. 15, Pages 580: Search of Novel Small Molecule Inhibitors for the Main Protease of SARS-CoV-2
Lin The current outbreak of coronavirus disease 2019 (COVID-19) has prompted the necessity of efficient treatment strategies. The COVID-19 pandemic was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Main protease (Mpro), also called 3-chymotrypsin-like protease (3CL protease), plays an essential role in cleaving virus polyproteins for the functional replication complex. Therefore, Mpro is a promising drug target for COVID-19 therapy. Through molecular modelling, docking and a protease activity assay, we found four novel inhibitors targeting Mpro with the half maximal inhibitory concentratio...
Source: Viruses - February 20, 2023 Category: Virology Authors: Wenfa Zhang Sheng-Xiang Lin Tags: Article Source Type: research

Viruses, Vol. 15, Pages 578: Human Coronavirus OC43 as a Low-Risk Model to Study COVID-19
Lee The coronavirus disease 2019 (COVID-19) pandemic has had irreversible and devastating impacts on every aspect of human life. To better prepare for the next similar pandemic, a clear understanding of coronavirus biology is a prerequisite. Nevertheless, the high-risk nature of the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), requires the use of a cumbersome biosafety level-3 (BSL-3) confinement facility. To facilitate the development of preventive and therapeutic measures against SARS-CoV-2, one of the endemic strains of low-risk coronaviruses has gained attention as a us...
Source: Viruses - February 20, 2023 Category: Virology Authors: Mi Il Kim Choongho Lee Tags: Review Source Type: research

Viruses, Vol. 15, Pages 555: RBD and Spike DNA-Based Immunization in Rabbits Elicited IgG Avidity Maturation and High Neutralizing Antibody Responses against SARS-CoV-2
or Renato M. Astray Regina M. Catarino Marcelo Lancelotti Carlos R. Prudencio Neutralizing antibodies (nAbs) are a critical part of coronavirus disease 2019 (COVID-19) research as they are used to gain insight into the immune response to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infections. Among the technologies available for generating nAbs, DNA-based immunization methods are an alternative to conventional protocols. In this pilot study, we investigated whether DNA-based immunization by needle injection in rabbits was a viable approach to produce a functional antibody response. We d...
Source: Viruses - February 17, 2023 Category: Virology Authors: Hernan H. M. da Costa Diego J. B. Orts Andrew D. Moura Amaro N. Duarte-Neto Cinthya S. Cirqueira Rodrigo A. R éssio Cristina T. Kanamura Karen Miguita Jerenice E. Ferreira Raimunda T. M. Santos Patricia P. Adriani Jair P. Cunha-Junior Renato M. Astray Re Tags: Brief Report Source Type: research

Viruses, Vol. 15, Pages 560: Evaluating Data Sharing of SARS-CoV-2 Genomes for Molecular Epidemiology across the COVID-19 Pandemic
Soares Following the emergence of COVID-19 in December 2019, caused by the coronavirus SARS-CoV-2, the disease spread dramatically worldwide. The use of genomics to trace the dissemination of the virus and the identification of novel variants was essential in defining measures for containing the disease. We aim to evaluate the global effort to genomically characterize the circulating lineages of SARS-CoV-2, considering the data deposited in GISAID, the major platform for data sharing in a massive worldwide collaborative undertaking. We contextualize data for nearly three years (January 2020–October 2022)...
Source: Viruses - February 17, 2023 Category: Virology Authors: Teresa Rito Pedro Fernandes Raquel Duarte Pedro Soares Tags: Article Source Type: research

Viruses, Vol. 15, Pages 553: Hyperinflammatory Response in COVID-19: A Systematic Review
Costa Lima COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory response that cause systemic inflammation are extremely linked to its severity. This research sought to review the immunopathological elements that contribute to its progression. This is a systematic review using the PUBMED, LILACS, MEDLINE, and SCIELO databases using articles between May 2020 and July 2022 with the following search terms in conjunction with “AND”: “SARS-CoV-2”; &am...
Source: Viruses - February 16, 2023 Category: Virology Authors: Marcos Jess é Abrahão Silva Layana Rufino Ribeiro Maria Isabel Montoril Gouveia Beatriz dos Reis Marcelino Carolynne Silva dos Santos Karla Val éria Batista Lima Luana Nepomuceno Gondim Costa Lima Tags: Review Source Type: research

Viruses, Vol. 15, Pages 543: Real-World Effectiveness of SARS-CoV-2 Vaccine Booster in Hemodialysis Patients with COVID-19 Receiving Molnupiravir
In conclusion, for HD patients with initially mild or asymptomatic COVID-19 receiving molnupiravir, the benefits of SARS-CoV-2 vaccine boosters are prominent, irrespective of booster vaccine types.
Source: Viruses - February 16, 2023 Category: Virology Authors: Po-Chun Chen Chiang-Chi Huang Chung-Ming Fu Yi-Chin Chang Po-Jung Wu Wen-Chin Lee Chien-Te Lee Kai-Fan Tsai Tags: Article Source Type: research

Viruses, Vol. 15, Pages 525: Immunometabolic Signature during Respiratory Viral Infection: A Potential Target for Host-Directed Therapies
aes-Vieira RNA viruses are known to induce a wide variety of respiratory tract illnesses, from simple colds to the latest coronavirus pandemic, causing effects on public health and the economy worldwide. Influenza virus (IV), parainfluenza virus (PIV), metapneumovirus (MPV), respiratory syncytial virus (RSV), rhinovirus (RhV), and coronavirus (CoV) are some of the most notable RNA viruses. Despite efforts, due to the high mutation rate, there are still no effective and scalable treatments that accompany the rapid emergence of new diseases associated with respiratory RNA viruses. Host-directed therapies have been applie...
Source: Viruses - February 13, 2023 Category: Virology Authors: Larissa Menezes dos Reis Marcelo Rodrigues Ber çot Bianca Gazieri Castelucci Ana Julia Estumano Martins Gisele Castro Pedro M. Moraes-Vieira Tags: Review Source Type: research

Viruses, Vol. 15, Pages 508: Impact of COVID-19 on Cardiovascular Disease
ugger Coronavirus disease 2019 (COVID-19) is a viral infection with the novel severe acute respiratory distress syndrome corona virus 2 (SARS-CoV-2). Until now, more than 670 million people have suffered from COVID-19 worldwide, and roughly 7 million death cases were attributed to COVID-19. Recent evidence suggests an interplay between COVID-19 and cardiovascular disease (CVD). COVID-19 may serve as a yet underappreciated CVD risk modifier, including risk factors such as diabetes mellitus or arterial hypertension. In addition, recent data suggest that previous COVID-19 may increase the risk for many entities of CVD to ...
Source: Viruses - February 11, 2023 Category: Virology Authors: Ivan Vosko Andreas Zirlik Heiko Bugger Tags: Review Source Type: research

Viruses, Vol. 15, Pages 493: Short and Long-Term Cardiovascular Sequelae after SARS-CoV-2 Infection: A Narrative Review Focusing on Athletes
The objective of our narrative review is to provide an updated summary of the literature on CV involvement after coronavirus disease 2019, both in the early post-infection period and over a longer period of time, with a focus on athletic populations.
Source: Viruses - February 10, 2023 Category: Virology Authors: Sara Monosilio Silvia Prosperi Maria Rosaria Squeo Stefano Spataro Antonio Spataro Viviana Maestrini Tags: Review Source Type: research

Viruses, Vol. 15, Pages 477: Using Multiplex Amplicon PCR Technology to Efficiently and Timely Generate Rift Valley Fever Virus Sequence Data for Genomic Surveillance
We report the first primer scheme approach of generating multiplex primer sets for a tripartite virus which can be replicated for other segmented viruses.
Source: Viruses - February 9, 2023 Category: Virology Authors: John Juma Samson L. Konongoi Isidore Nsengimana Reuben Mwangi James Akoko Richard Nyamota Collins Muli Paul O. Dobi Edward Kiritu Shebbar Osiany Amos A. Onwong ’a Rachael W. Gachogo Rosemary Sang Alan Christoffels Kristina Roesel Bernard Bett Samuel O. Tags: Article Source Type: research