Filtered By:
Source: Viruses

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 1003 results found since Jan 2013.

Viruses, Vol. 15, Pages 1623: Effects of COVID-19 Infection in Healthy Subjects on Cardiac Function and Biomarkers of Oxygen Transport, Blood Coagulation and Inflammation
Conclusions: LV filling, inflammation, blood coagulation, and hemoglobin appear to be influenced by COVID-19 infection in healthy participants. Our observations contribute to the definition of vulnerabilities in the apparently healthy subjects with long COVID-19. These vulnerabilities may be more severe in patients with certain chronic diseases.
Source: Viruses - July 25, 2023 Category: Virology Authors: Gumanova Gorshkov Bogdanova Korolev Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1616: Differences in Trends in Admissions and Outcomes among Patients from a Secondary Hospital in Madrid during the COVID-19 Pandemic: A Hospital-Based Epidemiological Analysis (2020 & ndash;2022)
This study highlights the impact of the COVID-19 pandemic on daily health care in terms of incidence, critical patients, and mortality. We describe the characteristics and clinical outcomes of patients, comparing variables over the different waves. We performed a descriptive, retrospective study using the historical records of patients hospitalized with COVID-19. We describe demographic characteristics, admissions, and occupancy. Time series allowed us to visualize and analyze trends and patterns, and identify several waves during the 27-month period. A total of 3315 patients had been hospitalized with confirmed COVID-19. ...
Source: Viruses - July 24, 2023 Category: Virology Authors: Rafael Garcia-Carretero Oscar Vazquez-Gomez Mar ía Ordoñez-Garcia Noelia Garrido-Pe ño Ruth Gil-Prieto Angel Gil-de-Miguel Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1591: Nicotinamide Efficiently Suppresses Porcine Epidemic Diarrhea Virus and Porcine Deltacoronavirus Replication
In this study, we investigated the effects of nicotinamide (NAM) on PEDV and PDCoV replication and found that NAM treatment significantly inhibited PEDV and PDCoV reproduction. Moreover, NAM plays an important role in replication processes. NAM primarily inhibited PEDV and PDCoV RNA and protein synthesis rather than other processes. Furthermore, we discovered that NAM treatment likely inhibits the replication of PEDV and PDCoV by downregulating the expression of transcription factors through activation of the ERK1/2/MAPK pathway. Overall, this study is the first to suggest that NAM might be not only an important antiviral ...
Source: Viruses - July 21, 2023 Category: Virology Authors: Mingxia Li Liping Zhang Li Pan Peng Zhou Ruiming Yu Zhongwang Zhang Jianliang Lv Huichen Guo Yonglu Wang Sa Xiao Xinsheng Liu Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1600: Human Post-Translational SUMOylation Modification of SARS-CoV-2 Nucleocapsid Protein Enhances Its Interaction Affinity with Itself and Plays a Critical Role in Its Nuclear Translocation
Jiayu Liao Viruses, such as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infect hosts and take advantage of host cellular machinery for genome replication and new virion production. Identifying and elucidating host pathways for viral infection is critical for understanding the development of the viral life cycle and novel therapeutics. The SARS-CoV-2 N protein is critical for viral RNA (vRNA) genome packaging in new virion formation. Using our quantitative Förster energy transfer/Mass spectrometry (qFRET/MS) coupled method and immunofluorescence imaging, we identified three SUMOylation si...
Source: Viruses - July 21, 2023 Category: Virology Authors: Vipul Madahar Runrui Dang Quanqing Zhang Chuchu Liu Victor G. J. Rodgers Jiayu Liao Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1598: Cerebrovascular Disease in COVID-19
h N. Nguyen Not in the history of transmissible illnesses has there been an infection as strongly associated with acute cerebrovascular disease as the novel human coronavirus SARS-CoV-2. While the risk of stroke has known associations with other viral infections, such as influenza and human immunodeficiency virus, the risk of ischemic and hemorrhagic stroke related to SARS-CoV-2 is unprecedented. Furthermore, the coronavirus disease 2019 (COVID-19) pandemic has so profoundly impacted psychosocial behaviors and modern medical care that we have witnessed shifts in epidemiology and have adapted our treatment practices to ...
Source: Viruses - July 21, 2023 Category: Virology Authors: James E. Siegler Savanna Dasgupta Mohamad Abdalkader Mary Penckofer Shadi Yaghi Thanh N. Nguyen Tags: Review Source Type: research

Viruses, Vol. 15, Pages 1583: SARS-CoV-2 Infection in Cities from the Southern Region of Bahia State, Brazil: Analysis of Variables Associated in Both Individual and Community Level
s Laine Lopes Silva de Jesus Karoline Almeida Piton Beatriz Santos Costa Beatriz Sena Moreira Gomes Vinicius Moreira Porto Emanuelly da Silva Oliveira Cibele Luz Oliveira Renato Fontana Bianca Mendes Maciel Mylene de Melo Silva Lauro Juliano Marin Sandra Rocha Gadelha The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), challenged public health systems worldwide. Individuals in low-income countries/regions are still at individual and community risk concerning inequality, sanitation, and economic conditions. Besides, during the pandemic, the transmiss...
Source: Viruses - July 20, 2023 Category: Virology Authors: Murillo Ferreira da Silva Uener Ribeiro dos Santos Fabr ício Barbosa Ferreira George Rego Albuquerque Ana Paula Melo Mariano Hllytchaikra Ferraz Fehlberg Íris Terezinha Santos de Santana P érola Rodrigues dos Santos Luciano Cardoso Santos Laine Lopes S Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1581: Genome Variability of Infectious Bronchitis Virus in Mexico: High Lineage Diversity and Recurrent Recombination
Ruben Pérez The avian infectious bronchitis virus (IBV) is a coronavirus that mutates frequently, leading to a contagious and acute disease that results in economic losses to the global poultry industry. Due to its genetic and serological diversity, IBV poses a challenge in preventing and controlling the pathogen. The full-length S1 sequence analysis identifies seven main genotypes (GI–GVII) comprising 35 viral lineages. In addition to the previously described lineage, a new GI lineage (GI-30) and two lineages from novel genotypes (GVIII-1 and GIX-1) have been described in Mexico. To prevent the sprea...
Source: Viruses - July 20, 2023 Category: Virology Authors: Ana Marandino Lizbeth Mendoza-Gonz ález Yanina Panzera Gonzalo Tom ás Joaqu ín Williman Claudia Techera Amanda Gayosso-V ázquez Vianey Ram írez-Andoney Rogelio Alonso-Morales Mauricio Realpe-Quintero Ruben P érez Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1577: Synergistic Activity of Remdesivir & ndash;Nirmatrelvir Combination on a SARS-CoV-2 In Vitro Model and a Case Report
Conclusions: Remdesivir–nirmatrelvir combination has synergic activity in vitro. This combination may have a role in immunosuppressed patients with severe COVID-19 and prolonged viral shedding.
Source: Viruses - July 19, 2023 Category: Virology Authors: Anna Gidari Samuele Sabbatini Elisabetta Schiaroli Sabrina Bastianelli Sara Pierucci Chiara Busti Lavinia Maria Saraca Luca Capogrossi Maria Bruna Pasticci Daniela Francisci Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1571: Effect of High Hydrostatic Pressure Processing and Holder Pasteurization of Human Milk on Inactivation of Human Coronavirus 229E and Hepatitis E Virus
In conclusion, we demonstrated that HHP and HoP treatments do not lead to complete inactivation of both surrogate virus models, indicating that these treatments cannot guarantee total viral safety of donor milk.
Source: Viruses - July 18, 2023 Category: Virology Authors: Peggy Bouquet Virginie Alexandre Marie De Lamballerie Delphine Ley Jean Lesage Anne Goffard Laurence Cocquerel Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1560: SARS-CoV-2 RNAemia and Disease Severity in COVID-19 Patients
Conclusions: Our study demonstrated that SARS-CoV-2 RNA viremia is a predictive risk factor for clinical severity in COVID-19 patients. Hence, we showed that blood RNAemia might be a critical marker for disease severity and mortality.
Source: Viruses - July 16, 2023 Category: Virology Authors: Merlin Jayalal Lawrence Panchali Choon-Mee Kim Jun-Won Seo Da-Young Kim Na-Ra Yun Dong-Min Kim Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1554: COVID-19 and Thromboembolic Events in the Pandemic and Pre-Pandemic Era: A Pediatric Cohort
In conclusion, our study shows an increased prevalence of TEs in children hospitalized with COVID-19 or MIS-C, if compared to children without COVID-19 or MIS-C in the pandemic period and in the pre-pandemic period. The prevalence of TEs was significantly higher in patients with MIS-C.
Source: Viruses - July 15, 2023 Category: Virology Authors: Chiara Rubino Camilla Bechini Mariangela Stinco Donatella Lasagni Giuseppe Indolfi Sandra Trapani Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1539: Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication
n Bernhard Biersack Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we synthesized and studied the antiviral properties of a novel nitrocatechol compound (1c) and other analogs that are structurally related to the catechol derivative dynasore. Interestingly, compound 1c strongly inhibited two DEDD box viral ribonucleases, HIV-1 RNase H and SARS-CoV-2 nsp14 3′-to-5′ exoribonuclease (ExoN). While 1c inhibited SARS-CoV-2 ExoN activity, it did not interfere with the mR...
Source: Viruses - July 13, 2023 Category: Virology Authors: Abhishek Asthana Angela Corona Woo-Jin Shin Mi-Jeong Kwak Christina Gaughan Enzo Tramontano Jae U. Jung Rainer Schobert Babal Kant Jha Robert H. Silverman Bernhard Biersack Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1531: Serological Survey of Retrovirus and Coronavirus Infections, including SARS-CoV-2, in Rural Stray Cats in The Netherlands, 2020 & ndash;2022
Viruses, Vol. 15, Pages 1531: Serological Survey of Retrovirus and Coronavirus Infections, including SARS-CoV-2, in Rural Stray Cats in The Netherlands, 2020–2022 Viruses doi: 10.3390/v15071531 Authors: Mirjam B. H. M. Duijvestijn Nancy N. M. P. Schuurman Johannes C. M. Vernooij Michelle A. J. M. van Leeuwen Berend-Jan Bosch Judith M. A. van den Brand Jaap A. Wagenaar Frank J. M. van Kuppeveld Herman F. Egberink Josanne H. Verhagen Stray cats can host (zoonotic) viral pathogens and act as a source of infection for domestic cats or humans. In this cross-sectional (sero)prevalence study, s...
Source: Viruses - July 12, 2023 Category: Virology Authors: Mirjam B. H. M. Duijvestijn Nancy N. M. P. Schuurman Johannes C. M. Vernooij Michelle A. J. M. van Leeuwen Berend-Jan Bosch Judith M. A. van den Brand Jaap A. Wagenaar Frank J. M. van Kuppeveld Herman F. Egberink Josanne H. Verhagen Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1520: Impact of B Cell Depletion on COVID-19 in Kidney Transplant Recipients
akashi Kenmochi Kidney transplant recipients are patients at high risk for coronavirus disease 2019 (COVID-19) due to being on immunosuppressive therapy. B cell depletion therapy, including rituximab, is an important strategy for ABO-incompatible transplants. However, knowledge about the effect of B cell depletion therapy on COVID-19 is lacking. Thirty kidney transplant recipients who developed COVID-19 were included in this study. To examine the impact of B cell depletion therapy, we retrospectively investigated the relationship between the background of the patients and the clinical outcome. Of the 30 patients, 13 re...
Source: Viruses - July 7, 2023 Category: Virology Authors: Naohiro Aida Taihei Ito Kei Kurihara Izumi Hiratsuka Megumi Shibata Atsushi Suzuki Midori Hasegawa Takashi Kenmochi Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1504: An Overview of the Conventional and Novel Methods Employed for SARS-CoV-2 Neutralizing Antibody Measurement
a Machado SARS-CoV-2 is the etiological agent of the coronavirus disease-19 (COVID-19) and is responsible for the pandemic that started in 2020. The virus enters the host cell through the interaction of its spike glycoprotein with the angiotensin converting enzyme-2 (ACE2) on the host cell’s surface. Antibodies present an important role during the infection and pathogenesis due to many reasons, including the neutralization of viruses by binding to different spike epitopes. Therefore, measuring the neutralizing antibody titers in the whole population is important for COVID-19’s epidemiology. ...
Source: Viruses - July 5, 2023 Category: Virology Authors: Vin ícius Pinto Costa Rocha Helenita Costa Quadros Ant ônio Márcio Santana Fernandes Luana Pereira Gon çalves Roberto Jos é da Silva Badaró Milena Botelho Pereira Soares Bruna Aparecida Souza Machado Tags: Review Source Type: research