Viruses, Vol. 14, Pages 2040: Clinical Follow-Up and Postmortem Findings in a Cat That Was Cured of Feline Infectious Peritonitis with an Oral Antiviral Drug Containing GS-441524

Viruses, Vol. 14, Pages 2040: Clinical Follow-Up and Postmortem Findings in a Cat That Was Cured of Feline Infectious Peritonitis with an Oral Antiviral Drug Containing GS-441524 Viruses doi: 10.3390/v14092040 Authors: Daniela Krentz Katharina Zwicklbauer Sandra Felten Michèle Bergmann Roswitha Dorsch Regina Hofmann-Lehmann Marina L. Meli Andrea M. Spiri Ulrich von Both Martin Alberer Anne Hönl Kaspar Matiasek Katrin Hartmann This is the first report on a clinical follow-up and postmortem examination of a cat that had been cured of feline infectious peritonitis (FIP) with ocular manifestation by successful treatment with an oral multicomponent drug containing GS-441524. The cat was 6 months old when clinical signs (recurrent fever, lethargy, lack of appetite, and fulminant anterior uveitis) appeared. FIP was diagnosed by ocular tissue immunohistochemistry after enucleation of the affected eye. The cat was a participant in a FIP treatment study, which was published recently. However, 240 days after leaving the clinic healthy, and 164 days after the end of the 84 days of treatment, the cured cat died in a road traffic accident. Upon full postmortem examination, including histopathology and immunohistochemistry, there were no residual FIP lesions observed apart from a generalized lymphadenopathy due to massive lymphoid hyperplasia. Neither feline coronavirus (FCoV) RNA nor FCoV antigen were identified by quantitative reverse transcription polyme...
Source: Viruses - Category: Virology Authors: Tags: Case Report Source Type: research