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Transient Adrenal Insufficiency Following Pfizer/BioNTech Coronavirus Disease-2019 Vaccine Overdose
The COVID-19 pandemic has already caused more than 6.5 million deaths worldwide.1 Although vaccines have been instrumental in controlling the pandemic, they have many adverse effects. The most common adverse effects include pain at the injection site, fatigue, headache, myalgia, arthralgia, pyrexia, and nausea.2,3 Because of the massive scale of vaccinations, there has been an increase in the number of adverse effects, some of which have been due to incorrect application of the vaccine.
Source: Journal of Emergency Nursing: JEN - September 16, 2023 Category: Nursing Authors: Erhan Altunbas, Emir Unal, Ozge Onur, Dilek Yagci Caglayik Tags: Case Review Source Type: research

15-month post-COVID syndrome in outpatients: Attributes, risk factors, outcomes, and vaccination status - longitudinal, observational, case-control study
ConclusionBased on the specific symptoms of PCS our findings show a shift in the pattern of recovery. We found no effect of SARS-CoV-2 vaccination on PCS recovery and recommend further studies to identify predicting biomarkers and targeted PCS therapeutics.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research

Prevalence, pathogenesis and spectrum of neurological symptoms in COVID-19 and post-COVID-19 syndrome: a narrative review
Med J Aust. 2023 Sep 4;219(5):230-236. doi: 10.5694/mja2.52063. Epub 2023 Aug 20.ABSTRACTNeurological symptoms are not uncommon during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and reflect a broad spectrum of neurological disorders of which clinicians should be aware. The underlying pathogenesis of neurological disease in coronavirus disease 2019 (COVID-19) may be due to four mechanisms of nervous system dysfunction and injury: i) direct viral neurological invasion; ii) immune dysregulation; iii) endothelial dysfunction and coagulopathy; and iv) severe systemic COVID-19 disease. Neurological ma...
Source: Medical Journal of Australia - September 3, 2023 Category: General Medicine Authors: Robb Wesselingh Source Type: research

15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection
After the outbreak of COVID-19 infection, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection led to disability, hospitalization and death of a large number of people around the world [1]. This virus belongs to the Coronaviridae family that is a single-stranded RNA virus (positive-sense) and causes the spectrum of clinical manifestations in infected patients ranging from fever, cough, chest and body pain, myalgia, dyspnea, headache to mortality [2]. Adult male and elderly are more vulnerable to the disease, and cardiac, diabetic, and metabolic diseases are considered as main risk factors for this infection [3].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - September 3, 2023 Category: Biomedical Science Authors: Sara Kianfar, Vahid Salimi, Alireza Jahangirifard, Seyed Bashir Mirtajani, Mohammad Amin Vaezi, Jila Yavarian, Talat Mokhtari-Azad, Masoumeh Tavakoli-Yaraki Tags: Original research article Source Type: research

Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in COVID-19 patients
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus and the cause of coronavirus disease 2019 (COVID-19), a highly infectious respiratory illness characterized by fever, coughing, sore throat, fatigue, headache, muscle pain, and hemoptysis [1-3]. There has been an increased attention to otologic symptoms in COVID-19 patients [4, 5]. Upper respiratory tract infections often result in middle ear infections, although there is limited evidence of a causal relationship of COVID-19 and otitis media with effusions (OME) [6].
Source: International Journal of Infectious Diseases - August 31, 2023 Category: Infectious Diseases Authors: Yue Fan, Ruzhen Gao, Yingying Shang, Xu Tian, Yang Zhao, Xingming Chen Source Type: research

Coronavirus disease 2019 and malaria coinfection in a middle-aged Ethiopian woman presenting with acute febrile illness and bilateral pleural effusion: a case report
ConclusionClinicians should be aware of the possibility of coronavirus disease 2019 and malaria coinfection in any patient who is from malaria-endemic area and presenting with acute febrile illness symptoms such as fever and headache and respiratory complaints like shortness of breath and cough. Alhough viral etiologies such as coronavirus disease 2019 are rare causes of bilateral pleural effusion, they should be considered after ruling out other common causes.
Source: Journal of Medical Case Reports - August 31, 2023 Category: General Medicine Source Type: research

Changes in opioid prescribing in veterans with headache during the COVID-19 pandemic: A regression discontinuity in time analysis
CONCLUSION: Prescription opioid access was maintained for veterans within VHA during the pandemic. The de-escalation of opioid prescribing observed prior to the pandemic was not seen in our study.PMID:37596904 | DOI:10.1111/head.14605
Source: Headache - August 19, 2023 Category: Neurology Authors: Kaicheng Wang Brenda T Fenton Melissa Skanderson Anne C Black William C Becker Elizabeth K Seng Sarah E Anthony Alexander B Guirguis Hamada H Altalib Addison Kimber Nancy Lorenze Joel D Scholten Glenn D Graham Friedhelm Sandbrink Jason J Sico Source Type: research

Clinical characteristics of moderate or severe COVID ‐19 infection in patients with rheumatic diseases and analysis of risk factors leading to severe disease
ConclusionRD patients who suffered from moderate or severe COVID-19 infections have a higher risk of comorbidities, higher levels of inflammation, and longer hospitalized course. Dizziness and headache, CRP  >  8 mg/L and LDH >  248 μ/L are risk factors for severe COVID-19 infections in RD patients.
Source: International Journal of Rheumatic Diseases - August 8, 2023 Category: Rheumatology Authors: Wen Wang, Xiang Sun, Ran Fan, Ling ‐xiao Xu, Jian‐ping Tang Tags: ORIGINAL ARTICLE Source Type: research

Neurologic Manifestations of Coronavirus Disease 2019 in Children: An Iranian Hospital-Based Study
CONCLUSION: During the current pandemic outbreak, hospitalized children with COVID-19 should be evaluated for neurological signs because it is common among them and should not be under-estimated.PMID:37543939 | DOI:10.34172/aim.2023.25
Source: Archives of Iranian Medicine - August 6, 2023 Category: Middle East Health Authors: Elmira Haji Esmaeil Memar Morteza Heidari Homa Ghabeli Elham Pourbakhtyaran Roya Haghighi Seyyed Mohammad Mahdi Hosseiny Setareh Mamishi Shima Mahmoudi Hamid Eshaghi Ali Reza Tavasoli Mahmoud Mohammadi Reza Shervin Badv Gholamreza Zamani Masood Ghahvehchi Source Type: research