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Therapy: Stem Cell Therapy
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Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
The anti-inflammatory effects of mesenchymal stem cells attenuate diffuse pulmonary hemorrhage
This article is protected by copyright. All rights reserved.PMID:37735964 | DOI:10.1002/biot.202200632
Source: Biotechnology Journal - September 22, 2023 Category: Biotechnology Authors: Yajin Guan Qianqing Chen Jiahuan Xu Boyu Chen Baofang Ou Tianping Liu Shuiling Xie Yanan Bie Source Type: research
Modeling unveils sex differences of signaling networks in mouse embryonic stem cells
Mol Syst Biol. 2023 Sep 21:e11510. doi: 10.15252/msb.202211510. Online ahead of print.ABSTRACTFor a short period during early development of mammalian embryos, both X chromosomes in females are active, before dosage compensation is ensured through X-chromosome inactivation. In female mouse embryonic stem cells (mESCs), which carry two active X chromosomes, increased X-dosage affects cell signaling and impairs differentiation. The underlying mechanisms, however, remain poorly understood. To dissect X-dosage effects on the signaling network in mESCs, we combine systematic perturbation experiments with mathematical modeling. ...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Zeba Sultana Mathurin Dorel Bertram Klinger Anja Sieber Ilona Dunkel Nils Bl üthgen Edda G Schulz Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
Spatiotemporal, optogenetic control of gene expression in organoids
Nat Methods. 2023 Sep 21. doi: 10.1038/s41592-023-01986-w. Online ahead of print.ABSTRACTOrganoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of gene expression in organoids. Here we combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns. To illustrate the usefulness of our approach, we locally activated Sonic Hedgehog (SHH) signaling in an organoid model for human neurodevelopment. ...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ivano Legnini Lisa Emmenegger Alessandra Zappulo Agnieszka Rybak-Wolf Ricardo Wurmus Anna Oliveras Martinez Cledi Cerda Jara Anastasiya Boltengagen Tal é Hessler Guido Mastrobuoni Stefan Kempa Robert Zinzen Andrew Woehler Nikolaus Rajewsky Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
CONCLUSIONS: Besides the development of an epiretinal membrane in one patient, the intravitreal application of allogeneic BM-MSCs appeared to be intraocularly well tolerated. Consequently, not only NA-AION but also BM-MSCs deserve more clinical investigational resources and a larger randomized multicenter trial that would provide stronger evidence both about safety and the potential therapeutic efficacy of intravitreally injected allogeneic BM-MSCs in acute NA-AION.TRIAL REGISTRATION: Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NEUROSTEM). NCT03173638...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jose C Pastor Salvador Pastor-Idoate Marina L ópez-Paniagua Marta Para Francisco Blazquez Esther Murgui Ver ónica García Rosa M Coco-Mart ín Source Type: research
Advances of three-dimensional (3D) culture systems for in vitro spermatogenesis
Stem Cell Res Ther. 2023 Sep 21;14(1):262. doi: 10.1186/s13287-023-03466-6.ABSTRACTThe loss of germ cells and spermatogenic failure in non-obstructive azoospermia are believed to be the main causes of male infertility. Laboratory studies have used in vitro testicular models and different 3-dimensional (3D) culture systems for preservation, proliferation and differentiation of spermatogonial stem cells (SSCs) in recent decades. The establishment of testis-like structures would facilitate the study of drug and toxicity screening, pathological mechanisms and in vitro differentiation of SSCs which resulted in possible treatmen...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Maryam Salem Farnaz Khadivi Parinaz Javanbakht Sina Mojaverrostami Mehdi Abbasi Narjes Feizollahi Yasaman Abbasi Ehsan Heidarian Farzane Rezaei Yazdi Source Type: research
Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
CONCLUSIONS: In this study we report that an inherent enrichment of distinct GSCs pools underpin the functional inter-cluster variances displayed by GBM patients. We uncover two selectively represented novel functional biomarkers capable of discriminating GBM patients' stratification, survival and drug response, setting the stage for the determination of patient-tailored diagnostic and prognostic strategies and, mostly, for the design of appropriate, patient-selective treatment protocols.PMID:37735434 | DOI:10.1186/s13046-023-02811-0
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Alberto Visioli Nadia Trivieri Gandino Mencarelli Fabrizio Giani Massimiliano Copetti Orazio Palumbo Riccardo Pracella Maria Grazia Cariglia Chiara Barile Luigi Mischitelli Amata Amy Soriano Pietro Palumbo Federico Legnani Francesco DiMeco Leonardo Gorgog Source Type: research
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice
CONCLUSIONS: Our study highlights the beneficial effects of hUC-MSC treatment on PND and provides a justification to consider the potential use of hUC-MSCs in the perioperative period.PMID:37735415 | DOI:10.1186/s13287-023-03499-x
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Penghui Wei Min Jia Xiangyi Kong Wenyuan Lyu Hao Feng Xinyi Sun Jianjun Li Jian-Jun Yang Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis
medRxiv. 2023 Sep 7:2023.09.05.23295093. doi: 10.1101/2023.09.05.23295093. Preprint.ABSTRACTClonal hematopoiesis (CH), characterized by blood cells predominantly originating from a single mutated hematopoietic stem cell, is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD). While CH is common among older adults, the underlying factors driving its development are largely unknown. To address this, we performed whole-exome sequencing on 8,374 blood DNA samples collected from 4,187 Atherosclerosis Risk in Communities Study (ARIC) participants over a me...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Md Mesbah Uddin Seyedmohammad Saadatagah Abhishek Niroula Bing Yu Whitney Hornsby Shriienidhie Ganesh Kim Lannery Art Shuermans Michael C Honigberg Alexander G Bick Peter Libby Benjamin L Ebert Christie M Ballantyne Pradeep Natarajan Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering
Ann Biomed Eng. 2023 Sep 20. doi: 10.1007/s10439-023-03370-3. Online ahead of print.ABSTRACTTendon and ligament injuries account for a substantial proportion of disorders in the musculoskeletal system. While non-operative and operative treatment strategies have advanced, the restoration of native tendon and ligament structures after injury is still challenging due to its innate limited regenerative ability. Cell sheet technology is an innovative tool for tissue fabrication and cell transplantation in regenerative medicine. In this review, we first summarize different harvesting procedures and advantages of cell sheet techn...
Source: Annals of Biomedical Engineering - September 21, 2023 Category: Biomedical Engineering Authors: Yexin Li Ting Deng Dilihumaer Aili Yang Chen Weihong Zhu Qian Liu Source Type: research
