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Infectious Disease: Influenza
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Total 693 results found since Jan 2013.
Flu Vaccine ‘ Not A Very Good Match ’ For Strain That ’ s Tough On Children
(CNN) — This year’s flu vaccine is “not a very good match” for a common strain of the flu that’s especially tough on children, according to the nation’s top infectious disease doctor.
“It’s not a very good match for B/Victoria,” said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, referring to the strain. “It’s not an awful match, but it’s not a very good match.”
Children are particularly susceptible to influenza B/Victoria.
Fauci said even though the match for B/Victoria isn’t great, a flu shot can...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 14, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston CNN Flu Vaccine Source Type: news
Flu Rates Rising, Pediatric Deaths Double Compared to 2018: CDC Flu Rates Rising, Pediatric Deaths Double Compared to 2018: CDC
Influenza activity has been above the national baseline for the past 7 weeks, and the number of children who have died is twice as high as last season at this time.Medscape Medical News
Source: Medscape Allergy Headlines - December 31, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Flu Patients Get Better Sooner With Oseltamivir, Pragmatic Trial Shows Flu Patients Get Better Sooner With Oseltamivir, Pragmatic Trial Shows
A study from Europe provides estimates of the likely benefits of adding oseltamivir to usual care for patients with influenza-like illness.Reuters Health Information
Source: Medscape Allergy Headlines - December 20, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma
Live attenuated influenza vaccine (LAIV) is recommended for annual influenza vaccination in children from age 2 years. However, some guidelines recommend against its use in children with asthma or recurrent wheeze due to concerns over its potential to induce wheezing.
Source: Journal of Allergy and Clinical Immunology - December 17, 2019 Category: Allergy & Immunology Authors: Paul J. Turner, Louise Fleming, Sejal Saglani, Jo Southern, Nick J. Andrews, Elizabeth Miller, SNIFFLE-4 Study Investigators Source Type: research
Safety of Live Attenuated Influenza Vaccine in Children with Moderate-Severe Asthma
In a phase IV, multicenter prospective cohort study of 478 children with asthma, LAIV did not cause a significant change in asthma control, including in preschool children and young people with poorly controlled or difficult asthma.
Source: Journal of Allergy and Clinical Immunology - December 17, 2019 Category: Allergy & Immunology Authors: Paul J. Turner, Louise Fleming, Sejal Saglani, Jo Southern, Nick J. Andrews, Elizabeth Miller, SNIFFLE-4 Study Investigators Source Type: research
Flu Season Gets Bad Weeks Earlier Than Last Year, CDC Says Flu Season Gets Bad Weeks Earlier Than Last Year, CDC Says
Influenza activity is widespread or regional in more than half the country weeks earlier than last year, according to the CDC.Medscape Medical News
Source: Medscape Allergy Headlines - December 10, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Broadly Protective Influenza Vaccine Comprising a Cocktail of Inactivated Avian Influenza Viruses
There is a great need for broadly protective, “universal” influenza virus vaccines given the antigenic drift and shift of influenza viruses and the variable protective efficacy of the current influenza vaccines. This technology relates to a broadly protective, “universal” influenza vaccine candidate composed of a cocktail of different l ow pathogenicity avian influenza virus subtypes inactivated by betapropiolactone (BPL). Vaccinating animals with BPL-inactivated whole virus vaccine comprising influenza virus strains belonging to four or more different low pathogenicity avian influenza hemagglutinin subtypes, intra...
Source: NIH OTT Licensing Opportunities - December 5, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research
A High-Yield Perfusion-Based Transient Gene Expression Bioprocess
Currently, fed-batch processes are the most commonly used bioprocesses in transient gene expression (TGE) vaccine manufacturing. However, because fed-batch processes keep all the cells and protein product in the vessel throughout the run, some limitations are intrinsic. First, waste products like cell debris or other unwanted small molecules accumulate in the vessel with a potential to disrupt the cell growth, protein production, and the stability of the generated protein of interest. Second, necessary buffer exchange and/or cell concentration steps must be performed outside of the culturing vessel. These steps are more in...
Source: NIH OTT Licensing Opportunities - December 2, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research
Hemagglutinin-Based Universal Flu Vaccine Shows Early Promise Hemagglutinin-Based Universal Flu Vaccine Shows Early Promise
An influenza-vaccine candidate targeting the hemagglutinin (HA) stalk elicits cross-reactive antibodies in healthy human adults, according to interim results of a phase 1 clinical trial.Reuters Health Information
Source: Medscape Allergy Headlines - November 27, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Flu Season Is Here Early, Hitting Older Adults, Young Kids: CDC Flu Season Is Here Early, Hitting Older Adults, Young Kids: CDC
Levels of influenza-like illness activity have exceeded the baseline for 2 weeks running, according to the latest report from the Centers for Disease Control and Prevention.Medscape Medical News
Source: Medscape Allergy Headlines - November 22, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Microbiome landscape and disease duration role in allergy in adult patients with bronchiectasis
Conclusions: 1) The study showed that a longer DD and chronic colonization by pathogens are associated with higher levels of TS IgE in pts with B. 2) The most common pathogens are PA and HI in pts with B in Dnipro.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Gashynova, K., Suska, K., Dmytrychenko, V. Tags: Allergy and immunology Source Type: research
Treatment with Omalizumab in adults with severe allergic reduces Fc?I expression on dendritic cells and improves antiviral responses
Conclusion: Adults with severe allergic asthma demonstrate impaired systemic DC immune responses to IAV and RV. Treatment with Omalizumab, that results in reduced exacerbations is associated with reduced DC FcI expression, enhanced DC IFN-α/ responses to viruses and this effect is seen within 4 weeks treatment.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wark, P., Nichol, K., Dorahy, D., Collison, A., Mattes, J. Tags: Allergy and immunology Source Type: research
Matters of life and death: How estrogen and estrogen receptor binding to the immunoglobulin heavy chain locus may influence outcomes of infection, allergy, and autoimmune disease.
Abstract
Sex hormones are best known for their influences on reproduction, but they also have profound influences on the immune response. Examples of sex-specific differences include: (i) the relatively poor control of influenza virus infections in males compared to females, (ii) allergic asthma, an IgE-associated hypersensitivity reaction that is exacerbated in adolescent females compared to males, and (iii) systemic lupus erythematosus, a life-threatening autoimmune disease with a 9:1 female:male bias. Here we consider how estrogen and estrogen receptor α (ERα) may influence the immune response by modifying cl...
Source: Cellular Immunology - November 12, 2019 Category: Allergy & Immunology Authors: Jones BG, Penkert RR, Surman SL, Sealy RE, Pelletier S, Xu B, Neale G, Maul RW, Gearhart PJ, Hurwitz JL Tags: Cell Immunol Source Type: research
New immunodeficiency syndromes that help us understand the IFN-mediated antiviral immune response
Purpose of review
Studying primary immunodeficiencies (PIDs) provides insights into human antiviral immunity in the natural infectious environment. This review describes new PIDs with genetic defects that impair innate antiviral responses.
Recent findings
New genetic defects in the interferon (IFN) signaling pathway include IFNAR1 deficiency, which causes uncontrolled infections with measles-mumps-rubella or yellow fever vaccines, and possibly also cytomegalovirus (CMV); and IRF9 deficiency, which results in influenza virus susceptibility. Genetic defects in several pattern recognition receptors include MDA5 deficienc...
Source: Current Opinion in Pediatrics - November 7, 2019 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research
