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Infectious Disease: Influenza

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Influenza Vaccination Critical During Pandemic, CDC Says Influenza Vaccination Critical During Pandemic, CDC Says
The CDC is urging everyone to get vaccinated against influenza, saying it is even more important during the COVID-19 pandemic than in normal years.Medscape Medical News
Source: Medscape Allergy Headlines - August 21, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2020-21 Influenza Season.
This report updates the 2019-20 recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the United States (MMWR Recomm Rep 2019;68[No. RR-3]). Routine annual influenza vaccination is recommended for all persons aged ≥6 months who do not have contraindications. For each recipient, a licensed and age-appropriate vaccine should be used. Inactivated influenza vaccines (IIVs), recombinant influenza vaccine (RIV4), and live attenuated influenza vaccine (LAIV4) are expected to be available. Most influenza vaccines available for the 2020-21 season will be qua...
Source: MMWR Recomm Rep - August 20, 2020 Category: Epidemiology Authors: Grohskopf LA, Alyanak E, Broder KR, Blanton LH, Fry AM, Jernigan DB, Atmar RL Tags: MMWR Recomm Rep Source Type: research

Leading in Time of COVID: A True Test of Leadership
By Folake OlayinkaAug 15 2020 (IPS) In 1918, the Spanish Flu, a deadly influenza caused by the H1N1 virus, decimated the world. Over the course of four successive waves, it infected 500 million people, about a third of the world’s population at the time, resulting in 50 million deaths. More recently between 2014 and mid-2016 , the Ebola virus epidemic was the most widespread outbreak of Ebola virus disease in history—causing devastating  loss of life and socioeconomic disruption in the West Africa region, mainly in Guinea, Liberia and Sierra Leone. These outbreaks, as well as SARS and MERS, each have provided lessons...
Source: IPS Inter Press Service - Health - August 15, 2020 Category: International Medicine & Public Health Authors: Folake Olayinka Tags: Democracy Headlines Health Source Type: news

Influenza Vaccine Efficacy ' Undiminished ' in MS Influenza Vaccine Efficacy ' Undiminished ' in MS
The efficacy of the influenza vaccine when given to patients with multiple sclerosis is similar to that in healthy controls, according to an analysis of nine published cohort studies.Medscape Medical News
Source: Medscape Allergy Headlines - July 13, 2020 Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news

Protein Nanoparticles for Antigen Display in Vaccines
The technology relates to a protein-based nanoparticle platform that allows presentation of immunogenic molecules such as influenza virus antigens. This protein platform is made up of hepatitis B capsid/core proteins. The core proteins contain immunogenic loop c/e1, where other antigens can be inserted and the chimeric protein retains the ability to form capsid-like particles. The technology describes the insertion of one or more copies of influenza epitopes derived from the globular head or the stem region of hemagglutinin protein into or around the c/e1 loop of the core protein. The nanoparticles formed by the use of Hep...
Source: NIH OTT Licensing Opportunities - July 6, 2020 Category: Research Authors: ott-admin Source Type: research

Flu Vaccine Only 39% Effective This Past Season, CDC Panel Says Flu Vaccine Only 39% Effective This Past Season, CDC Panel Says
The influenza vaccine was even less effective against A/H1N1pmd09 virus but was better against B/Victoria virus, according to a CDC panel. They also voted on a new meningococcal vaccine.Medscape Medical News
Source: Medscape Allergy Headlines - June 25, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Host immune responses to influenza infection and vaccines: Lessons learned for all viral pandemic challenges.
PMID: 32564928 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - June 24, 2020 Category: Allergy & Immunology Authors: Engler RJM, Nelson MR Tags: Ann Allergy Asthma Immunol Source Type: research

Host immune responses to influenza infection and vaccines
Before the ravaging appearance of the severe acute respiratory syndrome coronavirus 2, influenza viruses have been among the major players in the history of health disasters over the past century.1,2 Because the 1918 Spanish flu pandemic claimed more than 50 million lives followed by annual resurgence of varying degrees of morbidity and mortality, the influenza vaccine program has driven platform development and global collaborative surveillance networks. These networks support the definition of antigenic shifts that drive annual vaccine specificities for manufacturing responses.
Source: Annals of Allergy, Asthma and Immunology - June 19, 2020 Category: Allergy & Immunology Authors: Renata J.M. Engler, Michael R. Nelson Tags: Editorial Source Type: research

Primary prevention
Nearly a year ago, the editors at the Annals of Allergy, Asthma& Immunology decided to put together an issue focused on vaccine technology and the importance of vaccination. At that time, we thought it was best to focus on respiratory virus vaccines (specifically for influenza and respiratory syncytial virus [RSV]), issues related to developing vaccines, and the distressing social movement against vaccination. Coronaviruses were not even considered. Now, we find ourselves in the middle of a pandemic created by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with a rush to develop a ...
Source: Annals of Allergy, Asthma and Immunology - June 19, 2020 Category: Allergy & Immunology Authors: Mitchell H. Grayson Tags: Editorial Source Type: research

Use of Google Trends to investigate loss ‐of‐smell‒related searches during the COVID‐19 outbreak
ConclusionThere is a strong correlation between the frequency of searches for smell ‐related information and the onset of COVID‐19 infection in Italy, Spain, UK, USA, Germany, France, Iran, and The Netherlands. We hypothesize this may relate to a previously underrecognized symptom.
Source: International Forum of Allergy and Rhinology - June 14, 2020 Category: Allergy & Immunology Authors: Abigail Walker, Claire Hopkins, Pavol Surda Tags: ORIGINAL ARTICLE Source Type: research

Positive Outcome in a COVID-19 patient with Common Variable Immunodeficiency after IVIG
We present a case of an immunodeficient patient patient who has recovered from COVID-19 infection. This is a 53-year-old female with Common Variable Immunodeficiency diagnosed in 1996 and has been on regular IVIG replacement therapy, GAMUNEX ®-C 40 grams (520 mg/ kg/ dose) every 2 weeks. Last IgG trough level was 1478 mg/dl on 11-12-19. High dose influenza vaccine administered in September 2019. The patient has also hypothyroidism, bronchiectasis, and Sjogren’s Syndrome treated with hydroxychloroquine 400 mg daily.
Source: Annals of Allergy, Asthma and Immunology - June 3, 2020 Category: Allergy & Immunology Authors: Rana Aljaberi, Kholoud Wishah Tags: Letters Source Type: research

Positive outcome in a patient with coronavirus disease 2019 and common variable immunodeficiency after intravenous immunoglobulin
We present a case of a patient with immunodeficiency who has recovered from coronavirus disease 2019 (COVID-19). The patient is a 53-year-old woman who received a diagnosis of common variable immunodeficiency in 1996 and has been on regular intravenous immunoglobulin (IVIG) replacement therapy with Gamunex-C 40 g (520 mg/kg/dose) every 2 weeks. The last immunoglobulin G trough level was 1478 mg/dL on November 12, 2019, and a high-dose influenza vaccine was administered in September 2019. The patient also has hypothyroidism, bronchiectasis, and Sjogren's syndrome treated with hydroxychloroquine 400 mg daily.
Source: Annals of Allergy, Asthma and Immunology - June 3, 2020 Category: Allergy & Immunology Authors: Rana Aljaberi, Kholoud Wishah Tags: Letters Source Type: research

Autopsy Data Show Extensive Lung Damage From COVID-19 Autopsy Data Show Extensive Lung Damage From COVID-19
A small autopsy study shows severe lung damage from COVID-19, but is it different than that seen in severe influenza? A thrombosis expert suggests the findings are not a surprise.Medscape Medical News
Source: Medscape Allergy Headlines - May 26, 2020 Category: Allergy & Immunology Tags: Cardiology News Source Type: news

How Remdesivir Moved From Back Shelf to Best Hope for Treating COVID-19
This study showed that a five-day regimen is as effective as 10 days–that’s important, doctors say, since it could mean shorter stays in the hospital, which could alleviate some of the burden on the health care system. “Of course we will have to wait for the final review of all the data, but it would be very nice to have an anti-viral that’s efficacious in this terrible illness,” says Dr. Aruna Subramanian, a clinical professor of medicine at Stanford and an investigator on the study. “At least we know that we can help patients with this, and that’s really the bottom line.” T...
Source: TIME: Health - May 21, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 feature Magazine Source Type: news

Moderna ’s COVID-19 Vaccine Shows Promise, Generating Positive Immune Responses in an Early Study
Earlier today, the biotech company Moderna reported positive results from a phase 1 study of its experimental COVID-19 vaccine, which was was among the first to begin testing in healthy human volunteers in mid-March. The study, led by the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health, involves 45 healthy people who received one of three different doses of the vaccine. According to Moderna, there are encouraging early signs that the shot generates antibodies against the COVID-19 virus, SARS-CoV-2, in levels that were similar to or higher than those seen in the plasma of p...
Source: TIME: Health - May 18, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news