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Infectious Disease: Influenza

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Total 693 results found since Jan 2013.

Sirtuin3 Alleviated Influenza A Virus-Induced Mitochondrial Oxidative Stress and Inflammation in Lung Epithelial Cells via Regulating Poly (ADP-Ribose) Polymerase 1 Activity
Conclusion: Overexpression of Sirt3 attenuated IAV-evoked inflammatory injury and mitochondrial oxidative stress through the inhibition of PARP-1 activity in lung epithelial cells.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 19, 2023 Category: Allergy & Immunology Source Type: research

Antibody Responses to the Host Microbiome in Chronic Rhinosinusitis
ConclusionsCompared to healthy controls, CRS patient's serum samples showed significantly increased sero-reactivity to both bacterial and viral proteins, reflecting recent or current infection or active colonization. Significantly higher antibodies againstStaphylococcus aureus, Human metapneumovirus, Human herpesvirus 5, and Human herpesvirus 4 in CRS needs further study.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - December 12, 2022 Category: Allergy & Immunology Authors: Devyani Lal, Lusheng Song, Tripti Brar, Emily K. Cope, Paul Keim, Stacy Williams, Yunro Chung, Vel Murugan, Joshua LaBaer, D. Mitchell Magee Tags: Original Article Source Type: research

Why You ’ re More Likely to Get Sick in the Winter, According to New Research
Fall and winter are traditionally boom times for respiratory viruses—a point well proven by this year’s confluence of influenza, RSV, and COVID-19. Almost 9 million people nationwide have been sickened by the flu already this season, RSV is surging among children, and COVID-19 continues to infect tens of thousands of people in the U.S. each day. But why does cold weather typically translate to cold and flu season? Experts often point to changes in human behavior—namely that chilly temperatures force people inside, where it’s easier for germs to spread. But a new study published in The Journal of All...
Source: TIME: Health - December 6, 2022 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Disease healthscienceclimate Source Type: news

Impaired cytokine production of circulating immune cells in severe asthma in response to Influenza virus
Conclusion: Impaired cytokine responses to acute IAV infection could explain the increased susceptibility to IAV in asthma and the increase in inflammation in exacerbations. This implicates a systemic immunodeficiency leading to an impaired activation of circulating leukocytes after recruitment to the infected tissue.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Jamal Jameel, K., Yanik, S., Kamaci, C., Weidinger, D., Buelthoff, E., Rohde, S., Yusuf, F., Kronsbein, J., Tenbusch, M., Knobloch, J. Tags: 05.03 - Allergy and immunology Source Type: research

Enhanced early T cell activation and protection from hyper-inflammation in smoke exposed Cox4i2-/- infected mice with influenza
Respiratory virus infections are a major cause of concern in chronic obstructive pulmonary disease (COPD). Mitochondrial reactive oxygen species (mtROS) play an important role in immune function and increased mtROS levels may have an effect in COPD. Cox4i2 regulates ROS production at complex III and has been shown implicated in the development of emphysema.We hypothesize that Cox4i2–/– mice are protected from smoke-induced hyper-inflammation but also exhibit impaired T cell activation and antiviral immunity.We analyzed T cell subsets, BAL Albumin leakage and virus load via qPCR. C57BL/6 (WT) and Cox4i2–/&...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Berger, T., Garcia Castro, C. F., Lakshmi, V., Völkel, S., Sommer, N., Skevaki, C. Tags: 05.03 - Allergy and immunology Source Type: research

Adult RSV: Q & A With the CDC ' s Michael Melgar, MD Adult RSV: Q & A With the CDC ' s Michael Melgar, MD
RSV is a common cause of respiratory disease in adults, but it can be difficult to differentiate from COVID-19 and influenza by symptoms alone.CDC Expert Commentary
Source: Medscape Allergy Headlines - November 11, 2022 Category: Allergy & Immunology Tags: Infectious Diseases Commentary Source Type: news

Increasing the percentage of patients that receive the influenza vaccine in allergy shot clinics
Vaccinations are a critical component of routine healthcare, and studies reveal that patients are more likely to receive vaccinations when they are recommended by a medical provider. In the US, annual influenza vaccine rates were 48.4% during the 2019-20 influenza season and 50.2% during the 2020-21 influenza season. The US Healthy People 2030 target goal is 70%.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: L. Flettrich, J. Gubin, M. Tankersley Tags: P045 Source Type: research

Brachial neuritis from the mrna sars-cov-2 and influenza vaccines
We report a case of brachial neuritis after the second mRNA SARS-CoV-2 which recurred after a subsequent influenza vaccine.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: J. VanLancker, D. Sheth Tags: M047 Source Type: research

Why the U.S. Doesn ’t Have a Nasal Vaccine for COVID-19
The U.S. led the world in quickly developing COVID-19 vaccines—one of the few bright spots in the country’s otherwise criticized response. But while injectable vaccines are effective in protecting people from getting sick with COVID-19, they are less able to block infection. In order to put the pandemic behind us, the world will need a way to stop infections and spread of the virus. That’s where a different type of vaccine, one that works at the places where the virus gets into the body, will likely prove useful. Here, though, the U.S. is losing its edge. In September, India approved a nasal COVID-19 vacc...
Source: TIME: Health - October 31, 2022 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

A New Lab-Made COVID-19 Virus Puts Gain-of-Function Research Under the Microscope
On October 14, a team of scientists at Boston University released a pre-print study reporting that they had created a version of SARS-CoV-2 combining two features of different, existing strains that boosted its virulence and transmissibility. Scientists and the public raised questions about the work, which refocused attention on such experiments, and prompted the U.S. government to investigate whether the research followed protocols for these kinds of studies. The concerns surround what is known as gain-of-function studies, in which viruses, bacteria, or other pathogens are created in the lab—either intentionally or ...
Source: TIME: Science - October 27, 2022 Category: Science Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

To thwart the next pandemic, ‘swientists’ hunt for flu viruses at U.S. hog shows
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Source: ScienceNOW - October 27, 2022 Category: Science Source Type: news

The Troubling Trends Pointing to a Severe Flu and RSV Season
Flu and respiratory syncytial virus (RSV) season has just begun in the northern hemisphere, and the consensus among experts is that the 2022-2023 season is shaping up to be more severe than in the past few (relatively mild) years. It might even be worse than seasons before COVID-19. Health data company IQVIA has been analyzing data from insurance claims filed by doctors’ offices, hospitals, and urgent care centers in the country for three decades, and focused on case trends over the previous year. The team found that diagnoses of flu are already tracking at record highs. Even before flu season began, back in spring 2...
Source: TIME: Health - October 25, 2022 Category: Consumer Health News Authors: Alice Park and Charts by Emily Barone Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

U.S. weighs crackdown on experiments that could make viruses more dangerous
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Source: ScienceNOW - October 19, 2022 Category: Science Source Type: news

Will the monkeypox virus become more dangerous?
A few years ago, researchers scoured the remains of 1867 people who lived between 30,000 and 150 years ago for genetic traces of variola, the virus that causes smallpox. In the teeth and bones of four Northern Europeans from the Viking era, they found enough DNA to reconstruct entire variola genomes. The sequenced viruses weren’t direct ancestors of the feared variola strain that was eradicated in the second half of the 20th century. But they may hold a clue to how smallpox became so deadly. Over the span of 350 years, the Viking virus lost several genes , the researchers reported in a 2020 paper in Science...
Source: Science of Aging Knowledge Environment - September 15, 2022 Category: Geriatrics Source Type: research

Almost everything Tucker Carlson said about Anthony Fauci this week was misleading or false
Tucker Carlson, a political commentator on Fox News, has long assailed Anthony Fauci for his role in the U.S. government’s response to the COVID-19 pandemic during both former President Donald Trump’s and President Joe Biden’s administrations. But on 22 August, when Fauci announced he would be retiring from his jobs as director of the U.S. National Institute of Allergy and Infectious Diseases (NIAID) and chief medical adviser to the president at the end of year, the Tucker Carlson Tonight host laid into him like never before. Carlson asserted Fauci had committed “very serious crimes” and said he “app...
Source: ScienceNOW - August 25, 2022 Category: Science Source Type: news