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Infectious Disease: Endemics

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Total 382 results found since Jan 2013.

Microbiological profile in chronic granulomatous disease patients in a single Brazilian primary immunodeficiency center
CONCLUSION: Staphylococcus sp., Staphylococcus aureus, and Aspergillus sp. were the most frequent agents found in this cohort. M. tuberculosis should be considered in endemic area. Detection of infectious agents drives to the adequate treatment and benefits the evolution of patients with CGD.PMID:33641311 | DOI:10.15586/aei.v49i2.82
Source: Allergologia et Immunopathologia - February 28, 2021 Category: Allergy & Immunology Authors: Aim ée Filippini Bifulco Oliveira Antonio Carlos Pastorino Mayra de Barros Dorna Ana Paula Beltran Moschione Castro Jos é Roberto Mendes Pegler Beni Morgenstern Magda Maria Sales Carneiro-Sampaio Source Type: research

We May Never Eliminate COVID-19. But We Can Learn to Live With It
When does a pandemic end? Is it when life regains a semblance of normality? Is it when the world reaches herd immunity, the benchmark at which enough people are immune to an infectious disease to stop its widespread circulation? Or is it when the disease is defeated, the last patient cured and the pathogen retired to the history books? The last scenario, in the case of COVID-19, is likely a ways off, if it ever arrives. The virus has infected more than 100 million people worldwide and killed more than 2 million. New viral variants even more contagious than those that started the pandemic are spreading across the world. And...
Source: TIME: Health - February 4, 2021 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cover Story COVID-19 feature Magazine Source Type: news

Identification of a New Human Monoclonal Antibody that More Potently Prevents Malaria Infection
Malaria is a major disease caused by a parasite transmitted through the bite of infected female mosquitoes. Globally, an estimated 214 million cases of malaria and 438,000 deaths from malaria occur annually, with chidren in African and South Asian regions being most vulnerable. Approximately 1,500-2,000 cases of malaria are reported in the United States each year, mostly in returning travelers from malaria- endemic countries. Among the international travelers, military personnel, diplomats, pregnant women, children and older individuals with weakened immune systems are more likely to be at risk of malaria infection and mor...
Source: NIH OTT Licensing Opportunities - November 13, 2020 Category: Research Authors: ott-admin Source Type: research

Genetic susceptibility to fungal infection in children
Purpose of review Fungal infections have steadily increased in incidence, emerging as a significant cause of morbidity and mortality in patients with iatrogenic immunosuppression. Simultaneously, we have witnessed a growing population of newly described inherited immune disorders that have enhanced our understanding of the human immune response against fungi. In the present review, we provide an overview and diagnostic roadmap to inherited disorders which confer susceptibility to superficial and invasive fungal infections. Recent findings Inborn errors of fungal immunity encompass a heterogeneous group of disord...
Source: Current Opinion in Pediatrics - November 11, 2020 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

M255 multifocal cerebral abscesses and pulmonary cavitary lesions in a male with altered mental status
Histoplasma is endemic in the Ohio-Mississippi River Valley. Most immunocompetent patients are asymptomatic; invasive disease warrants concern for primary or secondary immune defects. Concomitant bacterial infection leading to multiple cerebral abscesses in the setting of pulmonary histoplasmosis has not been reported.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: S. Kesh, K. Guarnieri, I. Slack, E. Kellner Source Type: research

Wild Polio Sufferers Reflect as Africa Declared Free of the Disease Wild Polio Sufferers Reflect as Africa Declared Free of the Disease
Thousands across Africa still live with the effects wild polio, but an African health agency declared the region free of endemic wild polio, four years after the last case was recorded in Nigeria.Reuters Health Information
Source: Medscape Allergy Headlines - August 26, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Safety of yellow fever vaccine administration in confirmed egg-allergic patients.
This study aims to describe the outcomes of yellow fever vaccination in patients with confirmed egg allergy (EA). Methods:A prospective study was conducted from January 2018 to September 2019. EA was diagnosed through positive oral food challenge (OFC), recent history of anaphylaxis following egg contact (anaphylaxis in the last 6 months) or immediate allergic reaction in the last 2 months with positive specific IgE. A skinprick test (SPT) with YFV was performed. If the SPT was negative, an intradermal test (ID) was performed at a 1:100 dilution. If the ID was negative, a full dose of YFV was administered. If the skin pr...
Source: Vaccine - August 19, 2020 Category: Allergy & Immunology Authors: Gerhardt CMB, Castro APBM, Pastorino AC, Dorna MB, Nunes-Santos CJ, Aquilante BP, Miyaji KT, Lopes MH Tags: Vaccine Source Type: research

Risk of Zika virus transmission from mother to unborn child much higher than expected
FINDINGSAccording to a new study by UCLA researchers and colleagues conducted in Brazil, 65% of children born to mothers infected withthe Zikavirusalsotested positive for the mosquito-borneinfection— a much higher rate than expected.The findings indicatethat even babies whohave no outward neurological or other symptoms associated with Zika can still be infected with the virus andare potentially at risk offuturedevelopmental problems.  BACKGROUNDThe study representsthe first time that the mother-to-child transmission rate of Zika has been reportedfor a group of children who were tracked over several years — including f...
Source: UCLA Newsroom: Health Sciences - July 27, 2020 Category: Universities & Medical Training Source Type: news

Human Ascariasis: An Updated Review.
CONCLUSION: The average cure rate with anthelminthic treatment is over 95%. Unfortunately, most treated patients in endemic areas become re-infected within months. Health education, personal hygiene, improved sanitary conditions, proper disposal of human excreta, and discontinuing the use of human fecal matter as a fertilizer are effective long-term preventive measures. Targeting deworming treatment and mass anthelminthic treatment should be considered in regions where A. lumbricoides is prevalent. PMID: 32628606 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 7, 2020 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Major Neutralization Site of Hepatitis E Virus and Use of this Neutralization Site in Methods of Vaccination
Hepatitis E is endemic in many countries throughout the developing world, in particular on the continents of Africa and Asia. The disease generally affects young adults and has a very high mortality rate, up to 20%, in pregnant women. This invention relates to the identification of a neutralization site of hepatitis E virus (HEV) and neutralizing antibodies that react with it. The neutralization site is located on a polypeptide from the ORF2 gene (capsid gene) of HEV. This neutralization site was identified using a panel of chimpanzee monoclonal antibodies that are virtually identical to human antibodies. Since this neutra...
Source: NIH OTT Licensing Opportunities - July 6, 2020 Category: Research Authors: ott-admin Source Type: research

Personalized medicine for asthma in tropical regions
Purpose of review Precision medicine could help to improve diagnosis and treatment of asthma; however, in the tropics there are special conditions to be considered for applying this strategy. In this review, we analyze recent advances of precision allergology in tropical regions, highlighting its limitations and needs in high-admixed populations living under environments with high exposure to house dust mites and helminth infections. Recent findings Advances have been made regarding the genetic characterization of the great diversity of populations living in the tropics. Genes involved in shared biological pathways be...
Source: Current Opinion in Allergy and Clinical Immunology - May 1, 2020 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research