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Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome
This study was carried out after written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Stanford University and UCLA Institutional Review Boards. Author Contributions MB provided patient care and obtained IRB approval. RO prepared histology images. MB, TT, and RB designed the research. TT and LP conducted experiments and analyzed data. MB made the molecular model. MB and TT wrote the manuscript. Funding Funding for this work came from the Jeffrey Modell Foundation and from the NIH/NIGMS (R01 GM110482 to MB)....
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children
Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and d...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies
Conclusions: NGS technology represents a powerful approach in the complex field of rare disorders but its different application should be weighted. A relatively small NGS target panel can be successfully applied for a robust diagnostic suspicion, while when the spectrum of clinical phenotypes overlaps more than one PID an in-depth NGS analysis is required, including also whole exome/genome sequencing to identify the causative gene. Introduction Primary immunodeficiencies (PIDs) are a phenotypically and genetically heterogeneous group of more than 300 monogenic inherited disorders resulting in immune defects that pred...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients
This study was approved by our local ethical review committee in compliance with the declaration of Helsinki. Informed and written consent was obtained from all patients (Ethic Committee Charité University Medicine, Berlin, Germany, EA2/028/13). The study cohort consisted of 7 kidney transplant recipients with sustained BKV reactivation (Table 1). The HLA typing for each patient and donor is summarized in Figure 1. TABLE 1 Table 1. Characteristics of patients with BKV reactivation. FIGURE 1 Figure 1. Recipient and donor HLA type. HLA type of the patients and their kidney donors. Black square i...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Fc γR-TLR Cross-Talk Enhances TNF Production by Human Monocyte-Derived DCs via IRF5-Dependent Gene Transcription and Glycolytic Reprogramming
This study was done according to the ethical guidelines of the Academic Medical Center and human material was obtained in accordance with the AMC Medical Ethics Review Committee according to the Medical Research Involving Human Subjects Act. Buffy coats obtained after blood donation (Sanquin blood supply) are not subjected to informed consent, which is according to the Medical Research Involving Human Subjects Act and the AMC Medical Ethics Review Committee. All samples were handled anonymously. Ethical review and approval was not required for this study in accordance with the local legislation. Monocytes were isolated fro...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Efficacy and safety of hydrolyzed rice-protein formulas for the treatment of cow's milk protein allergy.
Abstract Foods for special medical purposes (FSMPs) with a protein fraction made of hydrolyzed rice protein (HRPs) have been on the market in Europe since the 2000s for the treatment of cow's milk protein allergy (CMPA). HRP formulas (HRPFs) are proposed as a plant-based alternative to cow's milk protein-based extensively hydrolyzed formulas (CMP-eHF) beside the soy protein formulas whose use in CMPA is controversial. HRPFs do not contain phytoestrogens and are derived from non-genetically modified rice. HRPFs are strictly plant-based apart from the addition of vitamin D3 (cholecalciferol). As the amino acid conte...
Source: Archives de Pediatrie - April 8, 2019 Category: Pediatrics Authors: Bocquet A, Dupont C, Chouraqui JP, Darmaun D, Feillet F, Frelut ML, Girardet JP, Hankard R, Lapillonne A, Rozé JC, Simeoni U, Turck D, Briend A, Committee on Nutrition of the French Society of Pediatrics (CNSFP) Tags: Arch Pediatr Source Type: research

Omalizumab therapy for mast cell-mediator symptoms in patients with ISM, CM, MMAS and MCAS
ConclusionOmalizumab seems to be a useful therapeutic option to control mast cell-mediator symptoms and displays a favorable safety profile.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 5, 2019 Category: Allergy & Immunology Source Type: research

A Mysterious, Paralyzing Illness in Kids Is Worrying U.S. Health Officials: New Report
(NEW YORK) — One morning last fall, 4-year-old Joey Wilcox woke up with the left side of his face drooping. It was the first sign of an unfolding nightmare. Three days later, Joey was in a hospital intensive care unit, unable to move his arms or legs or sit up. Spinal taps and other tests failed to find a cause. Doctors worried he was about to lose the ability to breathe. “It’s devastating,” said his father, Jeremy Wilcox, of Herndon, Virginia. “Your healthy child can catch a cold — and then become paralyzed.” Joey, who survived but still suffers some of the effects, was one of 228...
Source: TIME: Health - April 2, 2019 Category: Consumer Health News Authors: MIKE STOBBE / AP Tags: Uncategorized illness medical onetime Source Type: news

Perception and practice of sublingual immunotherapy among practicing allergists in the United States: a follow-up survey.
The use of subcutaneous immunotherapy (SCIT) is a well-established treatment modality for allergic rhinoconjunctivitis since it was initially described by Noon and Freeman in 1911.1 This is the only disease-modifying treatment available. Sublingual immunotherapy (SLIT) has been used in Europe for decades, but is gaining popularity in the United States, especially with the recent FDA-approval of several SLIT products. Current products include ORALAIR ® (Stallergenes; Antony, France) which contains 5 northern grass pollens (Kentucky blue grass, orchard, perennial rye, sweet vernal, and Timothy), GRASTEK® (Merck; Whitehouse...
Source: Annals of Allergy, Asthma and Immunology - March 31, 2019 Category: Allergy & Immunology Authors: Anita Sivam, Mike Tankersley, ACAAI Immunotherapy and Diagnostics Committee Source Type: research

Family history of atopy in infants with cow's milk protein allergy: A French population-based study.
CONCLUSION: This French study confirms the high rate of family history of atopy in first-degree relatives of infants with probable or documented CMPA. PMID: 30885604 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - March 14, 2019 Category: Pediatrics Authors: Kalach N, Bellaïche M, Elias-Billon I, Dupont C Tags: Arch Pediatr Source Type: research

Spectrum of pulmonary aspergillosis in Hyper IgE syndrome with autosomal dominant STAT3 deficiency
ConclusionChronic and allergic forms of aspergillosis occurred in 17.5% of STAT3 deficient patients, mostly in lung cavities. Almost half had recurrences, despite prolonged antifungal treatment and/or surgery.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 14, 2019 Category: Allergy & Immunology Source Type: research

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
AbstractAimsMobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases.MethodsMASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a ...
Source: Clinical and Translational Allergy - March 10, 2019 Category: Allergy & Immunology Source Type: research

Evaluating the management of anaphylaxis in emergency departments: a survey in two French regions.
Authors: Lefèvre S, Klein R, De Blay F, Mertes PM PMID: 30832469 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - March 6, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Changes in persistent asthma care and outcomes from 2006 to 2016 in France
ConclusionChanges in persistent asthma care included replacement of ICS by FDCs, decreased use of LABAs as a monotherapy, and increased involvement of secondary care physicians. In parallel, despite low figures for hospital admissions and mortality, overall use of OCS and incidence of ER visits have increased over the last decade.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 4, 2019 Category: Allergy & Immunology Source Type: research