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Total 43 results found since Jan 2013.

Anti-tumor activity of trimethoprim-sulfamethoxazole against melanoma skin cancer through triggering allergic reaction and promoting immunity
This study examined the potential roles of TMP-SMX in melanoma skin cancer using an immunodeficient mouse model. TMP-SMX significantly improved the survival rate and reduced the tumor weight and growth and vascular endothelial growth factor levels in melanoma skin cancer of immunodeficient mice. In the forced swimming test, TMP-SMX significantly reduced immobility time compared to the melanoma skin cancer of immunodeficient mice, indicating improved immunity. TMP-SMX significantly increased infiltration of mast cells and release of allergy-related mediators (IgE, histamine, interleukin (IL)-4, IL-5, IL-13, and IL-33) and i...
Source: International Immunopharmacology - August 3, 2023 Category: Allergy & Immunology Authors: Hee-Yun Kim Ho-Geun Kang Hyung-Min Kim Hyun-Ja Jeong Source Type: research

520 A retrospective cohort study of patch testing in oral lichen planus and subsequent diagnosis of oral squamous cell carcinoma
Oral lichen planus (OLP) is a recalcitrant, relapsing autoimmune condition that poses a significant treatment challenge. Allergies to dental metals, fragrances, and additives have been documented in the setting of OLP. Likewise, oral squamous cell carcinoma (OSCC) has been reported to evolve in lesions of OLP. We hypothesized that the chronic inflammation of allergy-driven OLP may increase the odds of developing OSCC. Our primary objective was to compare the odds of OSCC between patch test negative and positive patients.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: V.N. Sahni, Z. Hopkins, J. Rhoads, J. Clarke, C. Hansen, D. Powell, R. deShazo, J. Zone, C. Hull Source Type: research

Natural products and their mechanisms in potential photoprotection of the skin
J Biosci. 2022;47:77.ABSTRACTExposure to solar radiation can generate different types of damage to the skin, including skin cancer. Depending on the duration of the exposure, sun damage can present as sunburn, photoaging, and photoimmunosuppression, among other effects. Using natural products on the skin may aid in preventing the damage caused by exposure to solar radiation, in addition to reducing the adverse side effects of common sunscreens, such as irritation, allergies, phototoxic reactions, photosensitivity, and generation of reactive oxygen species. On the other hand, the UV light absorption capacity of natural prod...
Source: Journal of Biosciences - December 13, 2022 Category: Biomedical Science Authors: Jcpizano -Andrade B Vargas -Guerrero C M Gurrola -Diaz J J Vargas -Radillo M A Ruiz -Lo Pez Source Type: research

Allergen immunotherapy, cancer, and immune disorders
Purpose of review The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years. Recent findings Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic f...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Exposome and Skin: Part 1. Bibliometric Analysis and Review of the Impact of Exposome Approaches on Dermatology
ConclusionsExposome studies are rapidly attracting interest in dermatology. The results of these studies will undoubtedly improve our understanding of why and under which circumstances some individuals develop skin disorders and help design tailored prevention strategies for patients suffering from these disorders.
Source: Dermatology and Therapy - February 3, 2022 Category: Dermatology Source Type: research

FDA: 7 Sunscreen Chemicals Enter Bloodstream After Use, But Don ’ t Abandon Sun Protection
(CNN) — After a single application, a total of seven chemicals commonly found in sunscreens can be absorbed into the bloodstream at levels that exceed safety thresholds, according to studies by the Center for Drug Evaluation and Research, an arm of the US Food and Drug Administration. “What is most alarming about these findings is that chemicals are absorbing into the body in significant amounts and the ingredients have not been fully tested for safety,” said David Andrews, a senior scientist for the Environmental Working Group, or EWG, a consumer organization which advocates for sunscreen safety. “...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 21, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Sunscreen Source Type: news

Naringenin Suppresses Chemically Induced Skin Cancer in Two-Stage Skin Carcinogenesis Mouse Model.
Conclusion: Naringenin exhibited anti-tumor effect in two stage carcinogenesis mouse skin tumor model. This study revealed that consumption of citrus fruits and the naringenin therein may be helpful in suppression of skin cancer. PMID: 31474152 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - September 1, 2019 Category: Cancer & Oncology Authors: Kumar R, Bhan Tiku A Tags: Nutr Cancer Source Type: research

Dermatological Disorders following Liver Transplantation: An Update.
Authors: Yadav DK, Bai XL, Liang T Abstract Patients undergoing liver transplantation (LT) are at a high risk of dermatological complications compared to the general population as a result of long-term use of immunosuppressant. However, the risk is not as high as other solid organ transplantations (SOT), particularly for skin cancer. The liver is considered as an immune privileged organ since it has a low prevalence of humoral rejection in contrast to other SOT, and thus, LT requires a minimal amount of immunosuppressants compared to other SOT recipients. However, because of the large volume of the liver, patients ...
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Sunscreen Enters Bloodstream After Just One Day Of Use, Study Says
This study is the FDA’s way of showing sunscreen manufacturers they need to do the studies to see if chemical absorption poses health risks.” The need to screen According to the Skin Cancer Foundation, more Americans are diagnosed with skin cancer each year than all other cancers combined. Around the world, melanoma ranks as the 19th most common cancer in both men and women, says the World Cancer Research Fund. In the United States, sunscreens were originally approved as an over-the-counter solution to sunburn. They came in two types: one using chemical combos to filter the sun, the other using minerals to bloc...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 6, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Sunscreen Source Type: news

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research