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Specialty: Neurology
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Total 80037 results found since Jan 2013.
Lumateperone Monotherapy for Treatment-Resistant OCD in an Adolescent
CNS Spectr. 2023 Sep 14:1-6. doi: 10.1017/S1092852923002468. Online ahead of print.NO ABSTRACTPMID:37706369 | DOI:10.1017/S1092852923002468
Source: CNS Spectrums - September 14, 2023 Category: Neurology Authors: Ahmed Naguy Saxby Pridmore Mohamed Y Abuzeid Dalal Elsori Bibi Alamiri Source Type: research
Artificial intelligence is set to transform mental health services
CNS Spectr. 2023 Sep 14:1-7. doi: 10.1017/S1092852923002456. Online ahead of print.NO ABSTRACTPMID:37706366 | DOI:10.1017/S1092852923002456
Source: CNS Spectrums - September 14, 2023 Category: Neurology Authors: Seithikurippu R Pandi-Perumal Meera Narasimhan Mary V Seeman Haitham Jahrami Source Type: research
Signatures of task learning in neural representations
Curr Opin Neurobiol. 2023 Sep 12;83:102759. doi: 10.1016/j.conb.2023.102759. Online ahead of print.ABSTRACTWhile neural plasticity has long been studied as the basis of learning, the growth of large-scale neural recording techniques provides a unique opportunity to study how learning-induced activity changes are coordinated across neurons within the same circuit. These distributed changes can be understood through an evolution of the geometry of neural manifolds and latent dynamics underlying new computations. In parallel, studies of multi-task and continual learning in artificial neural networks hint at a tradeoff between...
Source: Current Opinion in Neurobiology - September 14, 2023 Category: Neurology Authors: Harsha Gurnani N Alex Cayco Gajic Source Type: research
B cell depletion modulates glial responses and enhances blood vessel integrity in a model of multiple sclerosis
Neurobiol Dis. 2023 Sep 12:106290. doi: 10.1016/j.nbd.2023.106290. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is characterized by a compromised blood-brain barrier (BBB) resulting in central nervous system (CNS) entry of peripheral lymphocytes, including T cells and B cells. While T cells have largely been considered the main contributors to neuroinflammation in MS, the success of B cell depletion therapies suggests an important role for B cells in MS pathology. Glial cells in the CNS are essential components in both disease progression and recovery, raising the possibility that they represent targets for B cell...
Source: Neurobiology of Disease - September 14, 2023 Category: Neurology Authors: Julie J Ahn Yusra Islam Cheryl Clarkson-Paredes Molly T Karl Robert H Miller Source Type: research
Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking
Neurobiol Dis. 2023 Sep 12:106293. doi: 10.1016/j.nbd.2023.106293. Online ahead of print.ABSTRACTSpastic paraplegia type 11 (SPG11) is a common autosomal recessive form of hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor neuron axons, leading to muscle spasticity and weakness. Impaired lipid trafficking is an emerging pathology in neurodegenerative diseases including SPG11, though its role in axonal degeneration of human SPG11 neurons remains unknown. Here, we established a pluripotent stem cell-based SPG11 model by knocking down the SPG11 gene in human embryonic stem cells (hESCs). T...
Source: Neurobiology of Disease - September 14, 2023 Category: Neurology Authors: Eric Chai Zhenyu Chen Yongchao Mou Gitika Thakur Weihai Zhan Xue-Jun Li Source Type: research
Effect of Ferroptosis on chronic cerebral Hypoperfusion in vascular dementia
Exp Neurol. 2023 Sep 12:114538. doi: 10.1016/j.expneurol.2023.114538. Online ahead of print.ABSTRACTVascular dementia (VaD) is the second most prevalent type of dementia after Alzheimer's disease and is caused by impaired nerve cell function resulting from cerebrovascular disease and vascular risk factors. Chronic cerebral hypoperfusion (CCH) is a common pathological and physiological state that may result from cerebral ischemia and hypoxia, causing widespread diffuse lesions in the brain parenchyma which leads to progressive nerve damage. Transferrin (TF) and transferrin receptor 1 (TfR1), two proteins involved in iron up...
Source: Experimental Neurology - September 14, 2023 Category: Neurology Authors: Peijie Fu Yanghang Chen Moxin Wu Bing Bao Xiaoping Yin Zhiying Chen Manqing Zhang Source Type: research
A comparison of techniques for verifying the accuracy of precision decomposition-derived relationships between motor unit firing rates and recruitment thresholds from surface EMG signals
Exp Brain Res. 2023 Sep 14. doi: 10.1007/s00221-023-06694-7. Online ahead of print.ABSTRACTApproaches for validating motor unit firing times following surface electromyographic (EMG) signal decomposition with the precision decomposition III (PDIII) algorithm have not been agreed upon. Two approaches have been common: (1) "reconstruct-and-test" and (2) spike-triggered averaging (STA). We sought to compare motor unit results following the application of these approaches. Surface EMG signals were recorded from the vastus lateralis of 13 young males performing trapezoidal, isometric knee extensions at 50% and 80% of maximum vo...
Source: Brain Research - September 14, 2023 Category: Neurology Authors: Jonathan P Beausejour Paul Bohlen Kylie K Harmon Ryan M Girts Jason I Pagan Debbie L Hahs-Vaughn Trent J Herda Matt S Stock Source Type: research
Actual and counterfactual effort contribute to responsibility attributions in collaborative tasks
Cognition. 2023 Sep 12;241:105609. doi: 10.1016/j.cognition.2023.105609. Online ahead of print.ABSTRACTHow do people judge responsibility in collaborative tasks? Past work has proposed a number of metrics that people may use to attribute blame and credit to others, such as effort, competence, and force. Some theories consider only the actual effort or force (individuals are more responsible if they put forth more effort or force), whereas others consider counterfactuals (individuals are more responsible if some alternative behavior on their or their collaborator's part could have altered the outcome). Across four experimen...
Source: Cognition - September 14, 2023 Category: Neurology Authors: Yang Xiang Jenna Landy Fiery A Cushman Natalia V élez Samuel J Gershman Source Type: research
Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease
In conclusion, our study indicates that AST had a strong protective effect on PQ-induced oxidative stress and antagonized apoptotic cell death in SH-SY5Y cells and PQ-induced mice PD model, which might provide new insights of AST for PD treatment.PMID:37708917 | DOI:10.1016/j.brainresbull.2023.110762
Source: Brain Research Bulletin - September 14, 2023 Category: Neurology Authors: Lei Wang Kunliang Lu Xingyue Lou Shenghui Zhang Wenxin Song Ranran Li Lujing Geng Binfeng Cheng Source Type: research
Assessing communication, beyond just words
Eur J Paediatr Neurol. 2023 Sep 9:S1090-3798(23)00135-6. doi: 10.1016/j.ejpn.2023.09.002. Online ahead of print.NO ABSTRACTPMID:37709641 | DOI:10.1016/j.ejpn.2023.09.002
Source: European Journal of Paediatric Neurology - September 14, 2023 Category: Neurology Authors: Kimberly Goodspeed Source Type: research
Neurologists should retain diagnostic and therapeutic management of migraines
Neurol Neurochir Pol. 2023 Sep 14. doi: 10.5603/pjnns.96686. Online ahead of print.NO ABSTRACTPMID:37706667 | DOI:10.5603/pjnns.96686
Source: Neurologia i Neurochirurgia Polska - September 14, 2023 Category: Neurology Authors: Josef Finsterer Source Type: research
Childhood-onset epilepsy in patients with dyskinetic cerebral palsy caused by basal ganglia and thalamic lesions
CONCLUSIONS: One-third of term-born patients with BGTL-induced DCP caused by perinatal HIE develop epilepsy, and deep white matter lesions increase the likelihood of epilepsy. Preparation for early-onset ES, MS, and subsequent FS is beneficial.PMID:37708783 | DOI:10.1016/j.ejpn.2023.09.006
Source: European Journal of Paediatric Neurology - September 14, 2023 Category: Neurology Authors: Shizuka Nishimoto Yukihiro Kitai Satori Hirai Mika Hirotsune Naomi Okuyama Shodo Hirano Yukiko Mogami Hiroshi Arai Source Type: research
Phasic and tonic muscle synergies are different in number, structure and sparseness
This study aims at testing whether phasic and tonic components are generated by distinct phasic and tonic synergies or by the same set of synergies with phasic and tonic activation coefficients. The study also aims at characterizing the differences between the phasic and the tonic synergies. Using a comprehensive mapping of upper-limb point-to-point movements, synergies were extracted from phasic and tonic EMG signal separately, estimating the tonic components with a linear ramp model. The goodness of reconstruction (R2) as a function of the number of synergies was compared, and sets of synergies extracted from each datase...
Source: Human Movement Science - September 14, 2023 Category: Neurology Authors: Cristina Brambilla Marta Russo Andrea d'Avella Alessandro Scano Source Type: research
Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline
Brain Behav Immun. 2023 Sep 12:S0889-1591(23)00273-8. doi: 10.1016/j.bbi.2023.09.009. Online ahead of print.ABSTRACTAging is associated with a significant shift in immune system reactivity ("inflammaging"), as basal inflammation increases but protective responses to infection are compromised. The immune system exhibits considerable sex differences, which may influence the process of inflammaging, including immune cell activation and behavioral consequences of immune signaling (i.e., impaired memory). Here, we test the hypothesis that sex differences in immune aging may mediate sex differences in cognitive decline. Aged mal...
Source: Brain, Behavior, and Immunity - September 14, 2023 Category: Neurology Authors: Louise M Ince Jeffrey S Darling Kevin Sanchez Kiersten S Bell Jennifer K Melbourne Lourdes K Davis Kimberly Nixon Andrew D Gaudet Laura K Fonken Source Type: research
Masked priming under the Bayesian microscope: Exploring the integration of local elements into global shape through Bayesian model comparison
Conscious Cogn. 2023 Sep 12;115:103568. doi: 10.1016/j.concog.2023.103568. Online ahead of print.ABSTRACTTo investigate whether local elements are grouped into global shapes in the absence of awareness, we introduced two different masked priming designs (e.g., the classic dissociation paradigm and a trial-wise probe and prime discrimination task) and collected both objective (i.e., performance based) and subjective (using the perceptual awareness scale [PAS]) awareness measures. Prime visibility was manipulated using three different prime-mask stimulus onset asynchronies (SOAs) and an unmasked condition. Our results showed...
Source: Consciousness and Cognition - September 14, 2023 Category: Neurology Authors: Mikel Jimenez Antonio Prieto Pablo G ómez Jos é Antonio Hinojosa Pedro R Montoro Source Type: research
