International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Part-time training: levelling the playing field in Radiation Oncology
Despite decades of commitment to improving diversity in radiation oncology, the parameters remain stubbornly difficult to shift. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 18, 2024 Category: Radiology Authors: Farhannah Aly, Nicholas Bucknell, Liz Kenny, Fiona Hegi-Johnson Source Type: research

Salvage Stereotactic Radiosurgery for Recurrent WHO Grade 2 and 3 Meningiomas: A Multicenter Study (STORM)
The role of stereotactic radiosurgery (SRS) in the management of grade 2 and 3 meningiomas is not well elucidated. Unfortunately, local recurrence rates are high, and guidelines for management of recurrent disease are lacking. To address this knowledge gap, we conducted STORM, a multicenter retrospective cohort study of patients treated with primary SRS for recurrent grade 2 and 3 meningiomas. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 17, 2024 Category: Radiology Authors: Matthew Gallitto, Geoffrey Sedor, Albert Lee, Jared Pasetsky, Connor J Kinslow, Genesis De Los Santos, Derrick Obiri-Yeboah, Varun R Kshettry, Corbin A Helis, Michael D Chan, Thomas H Beckham, Susan L McGovern, Jennifer Matsui, Joshua D Palmer, Jonathan B Tags: Clinical Investigation Source Type: research

Putting the Brakes on Xerostomia in Oropharyngeal Cancer: Can Brachytherapy Be the Key?
There is no question as to the efficacy of brachytherapy in the management of de novo and recurrent head and neck cancers. It has been shown to contribute to both excellent oncologic outcomes in the upfront setting and durable local control and symptom relief in the recurrent setting.1-3 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Shauna McVorran, Arash Naghavi, Philip Schaner Tags: Editorial Source Type: research

Put on Your Thinking Cap: A Fungating Scalp Mass
A 66-year-old farmer with a medical history significant for multiple squamous cell carcinomas and basal cell carcinomas presented with a large posterior scalp mass of 6-month duration (fig 1). His symptoms included headaches alone with no focal neurologic deficits. The patient continues to smoke half a pack per day with 20 pack-years. On examination, a large fixed fungating scalp mass with ulcerations was present with no palpable cervical lymphadenopathy. Magnetic resonance imaging of the head showed a 8.2- × 6.1-cm enhancing invasive scalp soft tissue mass lesion with extension through the bilateral parietal calvarium (f...
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Romy J. Megahed, Mausam A. Patel Tags: Gray Zones Source Type: research

The Crown Jewel: Checkpoint Inhibition in Unresectable Cutaneous Squamous Cell Carcinoma
This is a complex case1 requiring multidisciplinary assessment. Given his non-melanoma skin cancer history, consideration should be given to whether the biopsy is representative of the entire lesion. We would not recommend upfront surgery for this locally advanced cutaneous squamous cell carcinoma with likely transdural spread and parenchymal brain and posterior sagittal sinus involvement. The survival for these cases is poor,2 and resection of the posterior sagittal sinus carries a high risk of venous infarction. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Lachlan McDowell, Catherine Barnett Tags: Gray Zone Expert Opinion Source Type: research

Moving Toward Personalized Medicine in Gynecologic Cancers
This Oncology Scan will cover multiple key studies presented or published recently, which highlight recent advances in gynecologic malignancies, where the need for personalized treatment has never been more apparent. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Michelle Ludwig, Neil Taunk, Junzo Chino, Lara Hathout, Eric Leung, Emma Fields Tags: Oncology Scan Source Type: research

Off the Top of Our Head
The current standard of care for locally advanced cutaneous squamous cell carcinoma consists of upfront resection followed by adjuvant radiation in the presence of high-risk features. In this case, several factors make surgery less desirable. We do not know whether there is tumor involvement of the sagittal sinus. Invasion of the sagittal sinus would preclude upfront surgery. Additionally, the extent of resection would require a large reconstruction with free tissue transfer. In the setting of active smoking, there is significant concern for failure of a free flap reconstruction. (Source: International Journal of Radiation...
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Michael J. Jelinek, Nikhil Joshi Tags: Gray Zone Source Type: research

Gray Matters: Managing Locally Advanced Skin Cancer Near the Brain
This patient1 presented with a cT4aN0M0 cutaneous squamous cell carcinoma (CSCC) of the bilateral parietal scalp, which is possibly recurrent after prior treatment. His symptoms and imaging suggest invasion of the calvarium (and possibly the superior sagittal sinus and brain) by the tumor. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Christopher A. Barker Tags: Gray Zone Source Type: research

In Regard to Laughlin et al.
Laughlin et al1 highlight the longitudinal toxicity and cosmesis as assessed by physicians and patients for moderately hypofractionated (MHF) and ultrahypofractionated (UHF) regimens. The trial's primary outcome was the complication rate at 24 months. Complications were defined as clinician-reported grade 3 toxicity or higher through the Common Terminology Criteria for Adverse Events (CTCAE) scale or worsening of clinician-reported cosmesis through the Harvard Cosmesis scale. Low rates of toxicity and excellent/good cosmesis were reported in both arms by clinicians and the conclusion was UHF had similar treatment-related e...
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Abdulla Al-Rashdan Tags: Letters to the Editor Source Type: research

In Reply to Al-Rashdan
Investigator-initiated studies managed within the radiation oncology clinical research office and radiation oncology statistical team (Visualization Laboratory) undergo some of the strictest clinical trial oversights in the United States. It is unlikely that the level of underreporting is higher than in any comparable study.1 One of the major strengths of our study is the thorough follow-up and evaluation of the treated patients within the same health system and constant communication between all providers involved in the care, which should minimize underreporting of adverse events (AEs). (Source: International Journal of ...
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Carlos E. Vargas, Brady S. Laughlin Tags: Letter to the Editor Source Type: research

In Regard to Dupere et al.
We present several key points that could affect neutron dose and risk assessments in pregnant patients receiving PBS-PT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Haibo Lin, Hang Qi, Minglei Kang, Charles B. Simone Tags: Letters to the Editor Source Type: research

In Reply to Lin et al.
We thank Lin et al1 for their comments and thank the editor for the opportunity to provide a response. We appreciate the concerns raised and agree it is crucial to exercise caution when treating pregnant patients whether using pencil beam scanning proton therapy (PBS-PRT) or x-ray therapy (XRT). Regardless of modality, fetal dose is influenced by prescription, target volume size, beam modifiers, beam angles, patient size, fetus-to-target distance, and so on. Gestational age is similarly an important consideration for either modality. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Justine M. Dupere, John J. Lucido, William G. Breen, Anita Mahajan, Nicholas B. Remmes Tags: Letter to the Editor Source Type: research

In Regard to Parikh et al.
We found the phase 2 trial by Parikh et al1 on ablative, 5-fraction, stereotactic magnetic resonance –guided, on-table adaptive radiation therapy (MRgRT-SMART) intriguing. Although we acknowledge MRgRT-SMART's promise, we emphasize the need for caution in suggesting its effect on disease management unless robust evidence is provided. Despite the authors not positioning MRgRT-SMART as the primary reference technology for pancreatic cancer, there may be an overemphasis on the widespread interpretation of this evidence. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Francesco Cellini, Michele Fiore Tags: Letters to the Editor Source Type: research

In Reply to Cellini and Fiore
We read with interest the letter from Cellini et al.,1 appreciate the commentary and questions, and would like to clarify a few points that were made: (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Parag J Parikh, Michael D Chuong, Percy Lee Tags: Letter to the Editor Source Type: research

Less Is More: A Hypofractionated Approach
This 66-year-old gentleman1 would benefit from neoadjuvant immunotherapy (IO), namely cemiplimab, which is an anti –programmed cell death protein 1 monoclonal antibody. A phase 2 multicenter study found administration of cemiplimab every 2 weeks resulted in an objective response rate in 44% of patients (13% complete response and 31% partial response) with a durable response in 63%.2 A more recent analysis foun d durable long-term disease-free survival among those who had a pathologic response.3 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Anna Lee, Jack Phan Tags: Gray Zone Source Type: research