An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice
We presently evaluated if curtailing oxidative stress and ER stress concomitantly using a combination of apocynin and tert-butylhydroquinone and salubrinal during the acute stage after TBI in mice reduces the severity of late-onset PD-like pathology. The effect of multiple low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on post-TBI neurodegeneration was also evaluated. The combo therapy elevated the level of phosphorylation at serine 129 (pS129) of α-Syn in the pericontusional cortex of male mice at 72 h post-TBI. Motor and cognitive deficits induced by TBI lasted at least 3 months and the combo therapy c...
Source: Experimental Neurology - April 24, 2024 Category: Neurology Authors: Charles K Davis Saivenkateshkomal Bathula Soomin Jeong Vijay Arruri Jeongwoo Choi Shruti Subramanian Carlie M Ostrom Raghu Vemuganti Source Type: research
Corrigendum to "RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage". Experimental Neurology. 2017 Sep: 295:116-124
Exp Neurol. 2024 Apr 23:114787. doi: 10.1016/j.expneurol.2024.114787. Online ahead of print.NO ABSTRACTPMID:38653705 | DOI:10.1016/j.expneurol.2024.114787 (Source: Experimental Neurology)
Source: Experimental Neurology - April 23, 2024 Category: Neurology Authors: Keren Zhou Ligen Shi None ZhenWang Jingyi Zhou Anatol Manaenko Cesar Reis Sheng Chen Jianmin Zhang Source Type: research
Corrigendum to "RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage". Experimental Neurology. 2017 Sep: 295:116-124
Exp Neurol. 2024 Apr 23:114787. doi: 10.1016/j.expneurol.2024.114787. Online ahead of print.NO ABSTRACTPMID:38653705 | DOI:10.1016/j.expneurol.2024.114787 (Source: Experimental Neurology)
Source: Experimental Neurology - April 23, 2024 Category: Neurology Authors: Keren Zhou Ligen Shi None ZhenWang Jingyi Zhou Anatol Manaenko Cesar Reis Sheng Chen Jianmin Zhang Source Type: research
Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model
Exp Neurol. 2024 Apr 20:114780. doi: 10.1016/j.expneurol.2024.114780. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disease characterized by dopaminergic neuron death and neuroinflammation. Emerging evidence points to the involvement of the transient receptor potential melastatin 2 (TRPM2) channel in neuron death and glial activation in several neurodegenerative diseases. However, the involvement of TRPM2 in PD and specifically its relation to the neuroinflammation aspect of the disease remains poorly understood. Here, we hypothesized that AG490, a TRPM2 inhibitor, can be used as a treatment...
Source: Experimental Neurology - April 22, 2024 Category: Neurology Authors: Ana Flavia F Ferreira Henning Ulrich Zhong-Ping Feng Hong-Shuo Sun Luiz Roberto Britto Source Type: research
Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice
In this study, using a murine contusive SCI model, we revealed that vMIP-II-Lamp2b-M2-Exo could target the chemokine receptors which highly expressed in the injured spinal cords, inhibit some key chemokine receptor signaling pathways (such as MAPK and Akt), further inhibit proinflammatory factors (such as IL-1β, IL-6, IL-17, IL-18, TNF-α, and iNOS), and promote anti-inflammatory factors (such as IL-4 and Arg1) productions, and the transformation of microglia/macrophages from M1 into M2. Moreover, the improved histological and functional recoveries were also found. Collectively, our results suggest that vMIP-II-Lamp2b-M2-...
Source: Experimental Neurology - April 20, 2024 Category: Neurology Authors: Gui-Qiang Fu Yang-Yang Wang Yao-Mei Xu Ming-Ming Bian Lin Zhang Hua-Zheng Yan Jian-Xiong Gao Jing-Lu Li Yu-Qing Chen Nan Zhang Shu-Qin Ding Rui Wang Jiang-Yan Li Jian-Guo Hu He-Zuo L ü Source Type: research
Activation of Wnt signaling mitigates blood-brain barrier disruption by inhibiting vesicular transcytosis after traumatic brain injury in mice
This study aims to elucidate the impact of Wnt/β-catenin signaling on cerebrovascular vesicular transcytosis following TBI. In this experiment, adult male wild-type (WT) C57BL/6 mice underwent various interventions. TBI was induced utilizing the controlled cortical impact technique. Post-TBI, mice were administered either an inhibitor or an agonist of Wnt signaling via intraperitoneal injection. Recombinant adeno-associated virus (rAAV) was administered intracerebroventricularly to modulate the expression of the CAV-1 inhibitory protein, Major facilitator superfamily domain-containing 2a (Mfsd2a). This research utilized E...
Source: Experimental Neurology - April 19, 2024 Category: Neurology Authors: Yuan Zhang Jianfeng Xu Pengcheng Li Bo Luo Hui Tang Source Type: research
Galectin-3 modulates microglial activation and neuroinflammation in early brain injury after subarachnoid hemorrhage
CONCLUSION: These findings suggest that regulating microglia polarization by galectin-3 after SAH to improve neuroinflammation may be a potential therapeutic target.PMID:38636772 | DOI:10.1016/j.expneurol.2024.114777 (Source: Experimental Neurology)
Source: Experimental Neurology - April 18, 2024 Category: Neurology Authors: Yuqi Shen Weiwei Zhang Hanxiao Chang Zheng Li Chao Lin Guangjian Zhang Lei Mao Chencheng Ma Ning Liu Hua Lu Source Type: research
Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats
In conclusion, suppression of neuronal proliferation and axonal outgrowth in IUGR rats resulted in cortical thinning and enlargement of lateral ventricles. TPO administration might be a novel therapeutic strategy for treating brain dysmaturation in IUGR infants.PMID:38636773 | DOI:10.1016/j.expneurol.2024.114781 (Source: Experimental Neurology)
Source: Experimental Neurology - April 18, 2024 Category: Neurology Authors: Satoru Takeshita Hiroki Kakita Nami Nakamura Mari Mori Kohki Toriuchi Hiromasa Aoki Yasumichi Inoue Hidetoshi Hayashi Yasumasa Yamada Mineyoshi Aoyama Source Type: research
An improved method for generating human spinal cord neural stem cells
Exp Neurol. 2024 Apr 15;376:114779. doi: 10.1016/j.expneurol.2024.114779. Online ahead of print.ABSTRACTNeural stem cells have exhibited efficacy in pre-clinical models of spinal cord injury (SCI) and are on a translational path to human testing. We recently reported that neural stem cells must be driven to a spinal cord fate to optimize host axonal regeneration into sites of implantation in the injured spinal cord, where they subsequently form neural relays across the lesion that support significant functional improvement. We also reported methods of deriving and culturing human spinal cord neural stem cells derived from ...
Source: Experimental Neurology - April 15, 2024 Category: Neurology Authors: Y Li H Kumamaru T J Vokes A N Tran C A Shevinsky L Graham K Archuleta K R Limon P Lu A Blesch M H Tuszynski J H Brock Source Type: research
An improved method for generating human spinal cord neural stem cells
Exp Neurol. 2024 Apr 13:114779. doi: 10.1016/j.expneurol.2024.114779. Online ahead of print.ABSTRACTNeural stem cells have exhibited efficacy in pre-clinical models of spinal cord injury (SCI) and are on a translational path to human testing. We recently reported that neural stem cells must be driven to a spinal cord fate to optimize host axonal regeneration into sites of implantation in the injured spinal cord, where they subsequently form neural relays across the lesion that support significant functional improvement. We also reported methods of deriving and culturing human spinal cord neural stem cells derived from embr...
Source: Experimental Neurology - April 15, 2024 Category: Neurology Authors: Y Li H Kumamaru T Vokes A Tran C Shevinsky L Graham K Archuleta K Limon P Lu A Blesch M H Tuszynski J H Brock Source Type: research
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function
Exp Neurol. 2024 Apr 10:114778. doi: 10.1016/j.expneurol.2024.114778. Online ahead of print.ABSTRACTNeuronal apoptosis is a common pathological change in early brain injury after subarachnoid hemorrhage (SAH), and it is closely associated with neurological deficits. According to previous research, p97 exhibits a remarkable anti-cardiomyocyte apoptosis effect. p97 is a critical molecule in the growth and development of the nervous system. However, it remains unknown whether p97 can exert an anti-neuronal apoptosis effect in SAH. In the present study, we examined the role of p97 in neuronal apoptosis induced after SAH and in...
Source: Experimental Neurology - April 12, 2024 Category: Neurology Authors: Wenping Cheng Boyang Wei Wenchao Liu Lei Jin Shenquan Guo Mingxiang Ding Yanchao Liu Haiyan Fan Ran Li Xin Zhang Xuying He Xifeng Li Chuanzhi Duan Source Type: research
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage
CONCLUSION: Exogenous LAMC1 treatment improved neurological deficits after SAH in rats, and attenuated neuronal apoptosis in both in vitro and in vivo SAH models, at least partially through the FAK/PI3K/AKT pathway.PMID:38609046 | DOI:10.1016/j.expneurol.2024.114776 (Source: Experimental Neurology)
Source: Experimental Neurology - April 12, 2024 Category: Neurology Authors: Qiaowei Wu Kaikun Yuan Yanting Yao Jinbiao Yao Jiang Shao Yuxiao Meng Pei Wu Huaizhang Shi Source Type: research
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function
Exp Neurol. 2024 Apr 10:114778. doi: 10.1016/j.expneurol.2024.114778. Online ahead of print.ABSTRACTNeuronal apoptosis is a common pathological change in early brain injury after subarachnoid hemorrhage (SAH), and it is closely associated with neurological deficits. According to previous research, p97 exhibits a remarkable anti-cardiomyocyte apoptosis effect. p97 is a critical molecule in the growth and development of the nervous system. However, it remains unknown whether p97 can exert an anti-neuronal apoptosis effect in SAH. In the present study, we examined the role of p97 in neuronal apoptosis induced after SAH and in...
Source: Experimental Neurology - April 12, 2024 Category: Neurology Authors: Wenping Cheng Boyang Wei Wenchao Liu Lei Jin Shenquan Guo Mingxiang Ding Yanchao Liu Haiyan Fan Ran Li Xin Zhang Xuying He Xifeng Li Chuanzhi Duan Source Type: research
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage
CONCLUSION: Exogenous LAMC1 treatment improved neurological deficits after SAH in rats, and attenuated neuronal apoptosis in both in vitro and in vivo SAH models, at least partially through the FAK/PI3K/AKT pathway.PMID:38609046 | DOI:10.1016/j.expneurol.2024.114776 (Source: Experimental Neurology)
Source: Experimental Neurology - April 12, 2024 Category: Neurology Authors: Qiaowei Wu Kaikun Yuan Yanting Yao Jinbiao Yao Jiang Shao Yuxiao Meng Pei Wu Huaizhang Shi Source Type: research
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function
Exp Neurol. 2024 Apr 10:114778. doi: 10.1016/j.expneurol.2024.114778. Online ahead of print.ABSTRACTNeuronal apoptosis is a common pathological change in early brain injury after subarachnoid hemorrhage (SAH), and it is closely associated with neurological deficits. According to previous research, p97 exhibits a remarkable anti-cardiomyocyte apoptosis effect. p97 is a critical molecule in the growth and development of the nervous system. However, it remains unknown whether p97 can exert an anti-neuronal apoptosis effect in SAH. In the present study, we examined the role of p97 in neuronal apoptosis induced after SAH and in...
Source: Experimental Neurology - April 12, 2024 Category: Neurology Authors: Wenping Cheng Boyang Wei Wenchao Liu Lei Jin Shenquan Guo Mingxiang Ding Yanchao Liu Haiyan Fan Ran Li Xin Zhang Xuying He Xifeng Li Chuanzhi Duan Source Type: research
