Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice
In this study, using a murine contusive SCI model, we revealed that vMIP-II-Lamp2b-M2-Exo could target the chemokine receptors which highly expressed in the injured spinal cords, inhibit some key chemokine receptor signaling pathways (such as MAPK and Akt), further inhibit proinflammatory factors (such as IL-1β, IL-6, IL-17, IL-18, TNF-α, and iNOS), and promote anti-inflammatory factors (such as IL-4 and Arg1) productions, and the transformation of microglia/macrophages from M1 into M2. Moreover, the improved histological and functional recoveries were also found. Collectively, our results suggest that vMIP-II-Lamp2b-M2-Exo may provide neuroprotection by targeting the injured spinal cord, inhibiting some chemokine signals, reducing proinflammatory factor production and modulating microglia/macrophage polarization.PMID:38642665 | DOI:10.1016/j.expneurol.2024.114784
Source: Experimental Neurology - Category: Neurology Authors: Gui-Qiang Fu Yang-Yang Wang Yao-Mei Xu Ming-Ming Bian Lin Zhang Hua-Zheng Yan Jian-Xiong Gao Jing-Lu Li Yu-Qing Chen Nan Zhang Shu-Qin Ding Rui Wang Jiang-Yan Li Jian-Guo Hu He-Zuo L ü Source Type: research