Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat
Prenatal nicotine exposure (PNE) has been documented to cause numerous deleterious effects on fetal development. However, the epigenetic changes promoted by nicotine exposure on germ cells are still not well u... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 7, 2024 Category: Genetics & Stem Cells Authors: Ouzna Dali, Jose Antonio Muriel-Muriel, Ana Vargas-Baco, Sergei Tevosian, Jasenka Zubcevic, Fatima Smagulova and Linda F. Hayward Tags: Methodology Source Type: research
The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies
Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE) lined by nuclear lamina, but the exact relationship remains unclear, espe... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 6, 2024 Category: Genetics & Stem Cells Authors: Alexander Y. Afanasyev, Yoonjin Kim, Igor S. Tolokh, Igor V. Sharakhov and Alexey V. Onufriev Tags: Research Source Type: research
Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress
Regulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with implications for the treatment of obesity and diabetes. Our preliminary analyses of RNA... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 27, 2024 Category: Genetics & Stem Cells Authors: Bethany C. Taylor, Loic H. Steinthal, Michelle Dias, Hari Krishna Yalamanchili, Scott A. Ochsner, Gladys E. Zapata, Nitesh R. Mehta, Neil J. McKenna, Nicolas L. Young and Alli M. Nuotio-Antar Tags: Research Source Type: research
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
In mammals, primordial germ cells (PGCs), the embryonic precursors of the germline, arise from embryonic or extra-embryonic cells upon induction by the surrounding tissues during gastrulation, according to mec... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 26, 2024 Category: Genetics & Stem Cells Authors: Cl émence Kress, Luc Jouneau and Bertrand Pain Tags: Research Source Type: research
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers
Nuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “closed” chromatin compartments, topologically associated domains (TADs) and chromatin loops. The DNA- and ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 20, 2024 Category: Genetics & Stem Cells Authors: Michael Camerino, William Chang and Ales Cvekl Tags: Research Source Type: research
The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
CTCF is highly likely to be the ancestor of proteins that contain large clusters of C2H2 zinc finger domains, and its conservation is observed across most bilaterian organisms. In mammals, CTCF is the primary ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 1, 2024 Category: Genetics & Stem Cells Authors: Sofia Kamalyan, Olga Kyrchanova, Natalia Klimenko, Valentin Babosha, Yulia Vasileva, Elena Belova, Dariya Fursenko, Oksana Maksimenko and Pavel Georgiev Tags: Research Source Type: research
Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Chromatin state is thought to impart regulatory function to the underlying DNA sequence. This can be established through histone modifications and chromatin organisation, but exactly how these factors relate t... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 25, 2024 Category: Genetics & Stem Cells Authors: Stefan A. Koestler, Madeleine L. Ball, Leila Muresan, Vineet Dinakaran and Robert White Tags: Research Source Type: research
Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi
Fusarium fujikuroi is a pathogen of rice causing diverse disease symptoms such as ‘bakanae’ or stunting, most likely due to the production of various natural products (NPs) during infection. Fusaria have the gene... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 20, 2024 Category: Genetics & Stem Cells Authors: Anna K. Atanasoff-Kardjalieff, Harald Berger, Katharina Steinert, Slavica Janevska, Nadia Ponts, Hans-Ulrich Humpf, Svetlana Kalinina and Lena Studt-Reinhold Tags: Research Source Type: research
TP63 –TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high rate of large genomic rearrangements are often observed in PRAD. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 14, 2024 Category: Genetics & Stem Cells Authors: R. Sultanov, A. Mulyukina, O. Zubkova, A. Fedoseeva, A. Bogomazova, K. Klimina, A. Larin, T. Zatsepin, T. Prikazchikova, M. Lukina, M. Bogomiakova, E. Sharova, E. Generozov, M. Lagarkova and G. Arapidi Tags: Research Source Type: research
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they also regulate cell signaling, metabolism, and translation. Des... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 1, 2024 Category: Genetics & Stem Cells Authors: Haley V. Hobble and Christine E. Schaner Tooley Tags: Review Source Type: research
Research progress of SWI/SNF complex in breast cancer
In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin remodeling complex whose mutations are associat... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 17, 2024 Category: Genetics & Stem Cells Authors: Kexuan Li, Baocai Wang and Haolin Hu Tags: Review Source Type: research
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-associated H3K27me3 histone modifications on opposite tails of the same nucleosome occur... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 10, 2024 Category: Genetics & Stem Cells Authors: Janith A. Seneviratne, William W. H. Ho, Eleanor Glancy and Melanie A. Eckersley-Maslin Tags: Methodology Source Type: research
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal an... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 23, 2024 Category: Genetics & Stem Cells Authors: Alexander Calderon, Tamara Mestvirishvili, Francesco Boccalatte, Kelly V. Ruggles and Gregory David Tags: Research Source Type: research
Role of sex in immune response and epigenetic mechanisms
The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inacti... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 22, 2024 Category: Genetics & Stem Cells Authors: Sombodhi Bhattacharya, Debasmita Sadhukhan and Radha Saraswathy Tags: Review Source Type: research
O-GlcNAcylation: the sweet side of epigenetics
Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function witho... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 14, 2023 Category: Genetics & Stem Cells Authors: Thomas Dupas, Benjamin Lauzier and Serge McGraw Tags: Review Source Type: research
