Quantification of biochemical PSA dynamics after radioligand therapy with [177Lu]Lu-PSMA-I & T using a population pharmacokinetic/pharmacodynamic model
There is an unmet need for prediction of treatment outcome or patient selection for [177Lu]Lu-PSMA therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). Quantification of the tumor exp... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 24, 2024 Category: Radiology Authors: Hinke Siebinga, Berlinda J. de Wit-van der Veen, Daphne M. V. de Vries-Huizing, Wouter V. Vogel, Jeroen J. M. A. Hendrikx and Alwin D. R. Huitema Tags: Original research Source Type: research
Phantom and clinical evaluation of the Bayesian penalised likelihood reconstruction algorithm Q.Clear without PSF correction in amyloid PET images
Bayesian penalised likelihood (BPL) reconstruction, which incorporates point-spread-function (PSF) correction, provides higher signal-to-noise ratios and more accurate quantitation than conventional ordered su... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 22, 2024 Category: Radiology Authors: Kei Wagatsuma, Muneyuki Sakata, Kenta Miwa, Yumi Hamano, Hirofumi Kawakami, Yuto Kamitaka, Tensho Yamao, Noriaki Miyaji, Kenji Ishibashi, Tetsuro Tago, Jun Toyohara and Kenji Ishii Tags: Original research Source Type: research
Joint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patients
In order to ensure adequate radiation protection of critical groups such as staff, caregivers and the general public coming into proximity of nuclear medicine (NM) patients, it is necessary to consider the imp... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 22, 2024 Category: Radiology Authors: Lara Struelens, Christelle Huet, David Broggio, J érémie Dabin, Laurent Desorgher, Augusto Giussani, Wei Bo Li, Dietmar Nosske, Yi-Kang Lee, Lidia Cunha, Maria J. R. Carapinha, Mario Medvedec and Peter Covens Tags: Original research Source Type: research
Gamma camera imaging characteristics of 166Ho and 99mTc used in Selective Internal Radiation Therapy
The administration of a 166Ho scout dose is available as an alternative to 99mTc particles for pre-treatment imaging in Selective Internal Radiation Therapy (SIRT). It has been reported that the 166Ho scout dose ... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 6, 2024 Category: Radiology Authors: David K ästner, Anja Braune, Claudia Brogsitter, Robert Freudenberg, Jörg Kotzerke and Enrico Michler Tags: Original research Source Type: research
Extended MRI-based PET motion correction for cardiac PET/MRI
A 2D image navigator (iNAV) based 3D whole-heart sequence has been used to perform MRI and PET non-rigid respiratory motion correction for hybrid PET/MRI. However, only the PET data acquired during the acquisi... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 6, 2024 Category: Radiology Authors: Mueez Aizaz, Jochem A. J. van der Pol, Alina Schneider, Camila Munoz, Robert J. Holtackers, Yvonne van Cauteren, Herman van Langen, Joan G. Meeder, Braim M. Rahel, Roel Wierts, Ren é M. Botnar, Claudia Prieto, Rik P. M. Moonen and M. Eline Kooi Tags: Original research Source Type: research
Bone marrow dosimetry in low volume mHSPC patients receiving Lu-177-PSMA therapy using SPECT/CT
Bone marrow toxicity in advanced prostate cancer patients who receive [177Lu]Lu-PSMA-617 is a well-known concern. In early stage patients; e.g. low volume metastatic hormone sensitive prostate cancer (mHSPC) pati... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 3, 2024 Category: Radiology Authors: Dagmar Grob, Bastiaan M. Priv é, Constantijn H. J. Muselaers, Niven Mehra, James Nagarajah, Mark W. Konijnenberg and Steffie M. B. Peters Tags: Original research Source Type: research
Impact of different models based on blood samples and images for bone marrow dosimetry after 177Lu-labeled somatostatin-receptor therapy
Peptide receptor radionuclide therapy with 177Lu-DOTATATE is a recognized option for treating neuroendocrine tumors and has few toxicities, except for the kidneys and bone marrow. The bone marrow dose is generall... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 2, 2024 Category: Radiology Authors: Delphine Vallot, S éverine Brillouet, Séléna Pondard, Lavinia Vija, Jean-Sébastien Texier, Lawrence Dierickx and Frédéric Courbon Tags: Original research Source Type: research
Impact of scatter correction on personalized dosimetry in selective internal radiotherapy using 166Ho-PLLA: a single-center study including Monte-Carlo simulation, phantom and patient imaging
Developments in transarterial radioembolization led to the conception of new microspheres loaded with holmium-166 (166Ho). However, due to the complexity of the scatter components in 166Ho single photon emission ... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 2, 2024 Category: Radiology Authors: Beno ît Collette, Marie Mannie-Corbisier, Ana-Maria Bucalau, Nicolas Pauly, Gontran Verset, Rodrigo Moreno-Reyes, Patrick Flamen and Nicola Trotta Tags: Original research Source Type: research
Optimising total knee replacement imaging: a novel 3D printed PET/CT anthropomorphic phantom for metal artefact simulation
Arthroplasty phantoms, including total knee replacement (TKR) phantoms, have been frequently used to test metal artefact reduction methods applied to positron emission tomography/computed tomography (PET/CT) i... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 28, 2024 Category: Radiology Authors: Rajeh Assiri, Karen Knapp, Jon Fulford and Junning Chen Tags: Original research Source Type: research
Assessment of the axial resolution of a compact gamma camera with coded aperture collimator
Handheld gamma cameras with coded aperture collimators are under investigation for intraoperative imaging in nuclear medicine. Coded apertures are a promising collimation technique for applications such as lym... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 21, 2024 Category: Radiology Authors: Tobias Mei ßner, Laura Antonia Cerbone, Paolo Russo, Werner Nahm and Jürgen Hesser Tags: Original research Source Type: research
Comparison of a 3D CZT and conventional SPECT/CT system for quantitative Lu-177 SPECT imaging
Next-generation SPECT/CT systems with CdZnTe (CZT) digital detectors in a ring-like setup are emerging to perform quantitative Lu-177 SPECT imaging in clinical routine. It is essential to assess how the shorte... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 19, 2024 Category: Radiology Authors: Victor Nuttens, Georg Schramm, Yves D ’Asseler and Michel Koole Tags: Original research Source Type: research
155Tb production by cyclotrons: what level of 155Gd enrichment allows clinical applications?
155Tb represents a potentially useful radionuclide for diagnostic medical applications, but its production remains a challenging problem, in spite of the fact that many production routes have been already investi... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 15, 2024 Category: Radiology Authors: Francesca Barbaro, Luciano Canton, Nikolay Uzunov, Laura De Nardo and Laura Melendez-Alafort Tags: Original research Source Type: research
Reduction of [68Ga]Ga-DOTA-TATE injected activity for digital PET/MR in comparison with analogue PET/CT
New digital detectors and block-sequential regularized expectation maximization (BSREM) reconstruction algorithm improve positron emission tomography (PET)/magnetic resonance (MR) image quality. The impact on ... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 15, 2024 Category: Radiology Authors: Christina P. W. Cox, Tessa Brabander, Erik Vegt, Quido G. de Lussanet de la Sabloni ère, Laura H. Graven, Frederik A. Verburg and Marcel Segbers Tags: Original research Source Type: research
Sequential deep learning image enhancement models improve diagnostic confidence, lesion detectability, and image reconstruction time in PET
Investigate the potential benefits of sequential deployment of two deep learning (DL) algorithms namely DL-Enhancement (DLE) and DL-based time-of-flight (ToF) (DLT). DLE aims to enhance the rapidly reconstruct... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 15, 2024 Category: Radiology Authors: Meghi Dedja, Abolfazl Mehranian, Kevin M. Bradley, Matthew D. Walker, Patrick A. Fielding, Scott D. Wollenweber, Robert Johnsen and Daniel R. McGowan Tags: Original research Source Type: research
Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers
Accurate image-derived input function (IDIF) from highly sensitive large axial field of view (LAFOV) PET/CT scanners could avoid the need of invasive blood sampling for kinetic modelling. The aim is to validat... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 13, 2024 Category: Radiology Authors: Xavier Palard-Novello, Denise Visser, Nelleke Tolboom, Charlotte L. C. Smith, Gerben Zwezerijnen, Elsmarieke van de Giessen, Marijke E. den Hollander, Frederik Barkhof, Albert D. Windhorst, Bart NM van Berckel, Ronald Boellaard and Maqsood Yaqub Tags: Original research Source Type: research
