A multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project
Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the r... (Source: EJNMMI Physics)
Source: EJNMMI Physics - July 23, 2021 Category: Radiology Authors: Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Nicholas Calvert, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzassarlidou, Michael Ljungberg, Daniel Tags: Original research Source Type: research
Renal 99mTc-DMSA pharmacokinetics in pediatric patients
99mTc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for 99mTc-DMSA in children, and currently available pediatric dose est... (Source: EJNMMI Physics)
Source: EJNMMI Physics - July 20, 2021 Category: Radiology Authors: Donika Plyku, Michael Ghaly, Ye Li, Justin L. Brown, Shannon O ’Reilly, Kitiwat Khamwan, Alison B. Goodkind, Briana Sexton-Stallone, Xinhua Cao, David Zurakowski, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch, Eric C. Frey and George Sgouros Tags: Original research Source Type: research
Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [11C]PiB amyloid imaging
Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate t... (Source: EJNMMI Physics)
Source: EJNMMI Physics - July 20, 2021 Category: Radiology Authors: Charles M. Laymon, Davneet S. Minhas, Sarah K. Royse, Howard J. Aizenstein, Ann D. Cohen, Dana L. Tudorascu and William E. Klunk Tags: Original research Source Type: research
Standardisation of conventional and advanced iterative reconstruction methods for Gallium-68 multi-centre PET-CT trials
To assess the applicability of the Fluorine-18 performance specifications defined by EANM Research Ltd (EARL), in Gallium-68 multi-centre PET-CT trials using conventional (ordered subset expectation maximisati... (Source: EJNMMI Physics)
Source: EJNMMI Physics - July 17, 2021 Category: Radiology Authors: Georgios Krokos, Lucy C. Pike, Gary J. R. Cook and Paul K. Marsden Tags: Original research Source Type: research
Internal dosimetry in F-18 FDG PET examinations based on long-time-measured organ activities using total-body PET/CT: does it make any difference from a short-time measurement?
A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-ac... (Source: EJNMMI Physics)
Source: EJNMMI Physics - July 15, 2021 Category: Radiology Authors: Pengcheng Hu, Xin Lin, Weihai Zhuo, Hui Tan, Tianwu Xie, Guobing Liu, Shuguang Chen, Xin Chen, Haojun Yu, Yiqiu Zhang, Hongcheng Shi and Haikuan Liu Tags: Original research Source Type: research
Optimizing reconstruction parameters for quantitative 124I-PET in the presence of therapeutic doses of 131I
The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for 124I-PET imaging in the presence of therapeutic levels of 131I. In this effort, images were acquired on a... (Source: EJNMMI Physics)
Source: EJNMMI Physics - July 12, 2021 Category: Radiology Authors: Louise M. Fanchon, Bradley J. Beattie, Keith Pentlow, Steven M. Larson and John L. Humm Tags: Original research Source Type: research
Automatic delineation and quantification of pulmonary vascular obstruction index in patients with pulmonary embolism using Perfusion SPECT-CT: a simulation study
In patients with pulmonary embolism (PE), there is a growing interest in quantifying the pulmonary vascular obtruction index (PVOI), which may be an independent risk factor for PE recurrence. Perfusion SPECT/C... (Source: EJNMMI Physics)
Source: EJNMMI Physics - July 5, 2021 Category: Radiology Authors: David Bourhis, Laura Wagner, Julien Rioult, Philippe Robin, Romain Le Pennec, C écile Tromeur, Pierre Yves Salaün and Pierre Yves Le Roux Tags: Original research Source Type: research
Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease
Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction techni... (Source: EJNMMI Physics)
Source: EJNMMI Physics - June 16, 2021 Category: Radiology Authors: Alina van de Burgt, Petra Dibbets-Schneider, Cornelis H. Slump, Arthur J. H. A. Scholte, Douwe E. Atsma, Lioe-Fee de Geus-Oei and Floris H. P. van Velden Tags: Original research Source Type: research
Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features
Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead... (Source: EJNMMI Physics)
Source: EJNMMI Physics - June 12, 2021 Category: Radiology Authors: Montserrat Carles, Tobias Fechter, Luis Mart í-Bonmatí, Dimos Baltas and Michael Mix Tags: Original research Source Type: research
Design and system evaluation of a dual-panel portable PET (DP-PET)
Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inhe... (Source: EJNMMI Physics)
Source: EJNMMI Physics - June 12, 2021 Category: Radiology Authors: Tianyi Zeng, Jiaxu Zheng, Xinyuan Xia, Xin Chen, Beien Wang, Shuangyue Zhang, Adam Chandler, Tuoyu Cao, Lingzhi Hu, Qun Chen and Xu Chu Tags: Original research Source Type: research
Y-90 SIRT: evaluation of TCP variation across dosimetric models
Much progress has been made in implementing selective internal radiation therapy (SIRT) as a viable treatment option for hepatic malignancies. However, there is still much need for improved options for calcula... (Source: EJNMMI Physics)
Source: EJNMMI Physics - June 10, 2021 Category: Radiology Authors: Benjamin J. Van, Yuni K. Dewaraja, Mamadou L. Sangogo and Justin K. Mikell Tags: Original research Source Type: research
Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer
The objective of this work was to apply the most recent biokinetic model for ra... (Source: EJNMMI Physics)
Source: EJNMMI Physics - June 2, 2021 Category: Radiology Authors: Vera H öllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos and Wei Bo Li Tags: Original research Source Type: research
Estimation of renal perfusion based on measurement of rubidium-82 clearance by PET/CT scanning in healthy subjects
Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF es... (Source: EJNMMI Physics)
Source: EJNMMI Physics - May 31, 2021 Category: Radiology Authors: Stine Sundgaard Langaa, Thomas Guldager Lauridsen, Frank Holden Mose, Claire Anne Fynbo, J ørn Theil and Jesper Nørgaard Bech Tags: Original research Source Type: research
Innovative procedure for measuring left ventricular ejection fraction from 18F-FDG first-pass ultra-sensitive digital PET/CT images: evaluation with an anthropomorphic heart phantom
Left ventricular ejection fraction (LVEF) is usually measured by cine-cardiac magnetic resonance imaging (MRI), planar and single-photon emission-computerized tomography (SPECT) equilibrium radionuclide angioc... (Source: EJNMMI Physics)
Source: EJNMMI Physics - May 20, 2021 Category: Radiology Authors: Emilie Verrecchia-Ramos, Olivier Morel, Paul Retif and Sinan Ben Mahmoud Tags: Original research Source Type: research
Performance evaluation of the Q.Clear reconstruction framework versus conventional reconstruction algorithms for quantitative brain PET-MR studies
Q.Clear is a Bayesian penalized likelihood (BPL) reconstruction algorithm that presents improvements in signal-to-noise ratio (SNR) in clinical positron emission tomography (PET) scans. Brain studies in resear... (Source: EJNMMI Physics)
Source: EJNMMI Physics - May 7, 2021 Category: Radiology Authors: Daniela Ribeiro, William Hallett and Adriana A. S. Tavares Tags: Original research Source Type: research
