Comparison of different methods for post-therapeutic dosimetry in [177Lu]Lu-PSMA-617 radioligand therapy
Dosimetry is of high importance for optimization of patient-individual PSMA-targeted radioligand therapy (PSMA-RLT). The aim of our study was to evaluate and compare the feasibility of different approaches of ... (Source: EJNMMI Physics)
Source: EJNMMI Physics - May 5, 2021 Category: Radiology Authors: Florian Rosar, Niklas Sch ön, Hendrik Bohnenberger, Mark Bartholomä, Tobias Stemler, Stephan Maus, Fadi Khreish, Samer Ezziddin and Andrea Schaefer-Schuler Tags: Original research Source Type: research
Population-based input function for TSPO quantification and kinetic modeling with [11C]-DPA-713
This study aims to as... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 29, 2021 Category: Radiology Authors: Mercy I. Akerele, Sara A. Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A. Gauthier, Ashish Raj, Claire Henchcliffe, P. David Mozley, Nicolas A. Karakatsanis, Ajay Gupta, John Babich and Sadek A. Nehmeh Tags: Original research Source Type: research
3D printing 18F radioactive phantoms for PET imaging
Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by crea... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 28, 2021 Category: Radiology Authors: Daniel Gillett, Daniel Marsden, Safia Ballout, Bala Attili, Nick Bird, Sarah Heard, Mark Gurnell, Iosif A. Mendichovszky and Luigi Aloj Tags: Original research Source Type: research
Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density
[11C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two ... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 23, 2021 Category: Radiology Authors: Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere and Michel Koole Tags: Short communication Source Type: research
Correction to: Influence of dosimetry method on bone lesion absorbed dose estimates in PSMA therapy: application to mCRPC patients receiving Lu-177-PSMA-I & T
An amendment to this paper has been published and can be accessed via the original article. (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 13, 2021 Category: Radiology Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido B öning Tags: Correction Source Type: research
The role of activity, scan duration and patient ’s body mass index in the optimization of FDG imaging protocols on a TOF-PET/CT scanner
Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administe... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 6, 2021 Category: Radiology Authors: Roberta Matheoud, Naema Al-Maymani, Alessia Oldani, Gian Mauro Sacchetti, Marco Brambilla and Alessandro Carriero Tags: Original research Source Type: research
Tissue dose estimation after extravasation of 177Lu-DOTATATE
Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234 –1243, 2017). Clinical management of thes... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 31, 2021 Category: Radiology Authors: Perrine Tylski, G éraldine Pina-Jomir, Claire Bournaud-Salinas and Patrice Jalade Tags: Original research Source Type: research
Effect of quantitative values on shortened acquisition duration in brain tumor 11C-methionine PET/CT
This study aims to clarify the effect of acquisition time shortenin... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 31, 2021 Category: Radiology Authors: Masatoshi Morimoto, Nobuyuki Kudomi, Yukito Maeda, Takuya Kobata, Akihiro Oishi, Keisuke Matsumoto, Toshihide Monden, Takanobu Iwasaki, Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto and Yoshihiro Nishiyama Tags: Original research Source Type: research
AI-based detection of lung lesions in [18F]FDG PET-CT from lung cancer patients
[18F]-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) is a well-established modality in the work-up of patients with suspected or confirmed diagnosis of lung cancer. Recent... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 25, 2021 Category: Radiology Authors: Pablo Borrelli, John Ly, Reza Kaboteh, Johannes Ul én, Olof Enqvist, Elin Trägårdh and Lars Edenbrandt Tags: Original research Source Type: research
Deep learning-based image quality improvement of 18F-fluorodeoxyglucose positron emission tomography: a retrospective observational study
Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of 18F-fluorodeoxyglucose positron emission ... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 25, 2021 Category: Radiology Authors: Junichi Tsuchiya, Kota Yokoyama, Ken Yamagiwa, Ryosuke Watanabe, Koichiro Kimura, Mitsuhiro Kishino, Chung Chan, Evren Asma and Ukihide Tateishi Tags: Original research Source Type: research
Evaluation of the PETsys TOFPET2 ASIC in multi-channel coincidence experiments
Aiming to measure the difference in arrival times of two coincident γ-photons with an accuracy in the order of 200ps, time-of-flight positron emission tomography systems commonly employ silicon photomultipliers (... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 24, 2021 Category: Radiology Authors: Vanessa Nadig, David Schug, Bjoern Weissler and Volkmar Schulz Tags: Original research Source Type: research
Validation of CARE kV automated tube voltage selection for PET-CT: PET quantification and CT radiation dose reduction in phantoms
Applied tube voltage (kilovolts, kV) and tube current (milliampere seconds, mAs) affect CT radiation dose and image quality and should be optimised for the individual patient. CARE kV determines the kV and mAs... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 20, 2021 Category: Radiology Authors: Natalie A. Bebbington, Troels J ørgensen, Erik Dupont and Mille A. Micheelsen Tags: Original research Source Type: research
The effect of calibration factors and recovery coefficients on 177Lu SPECT activity quantification accuracy: a Monte Carlo study
Different gamma camera calibration factor (CF) geometries have been proposed to convert SPECT data into units of activity concentration. However, no consensus has been reached on a standardised geometry. The C... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 18, 2021 Category: Radiology Authors: Keamogetswe Ramonaheng, Johannes A. van Staden and Hanlie du Raan Tags: Original research Source Type: research
Q-Bot: automatic DICOM metadata monitoring for the next level of quality management in nuclear medicine
Regular and precise inspection of the realization of the local nuclear medicine standard operation procedures (SOPs) is very complex and time-consuming, especially when large amount of patient data is obtained... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 18, 2021 Category: Radiology Authors: Ferenc Nagy, Aron K. Krizsan, Korn él Kukuts, Melinda Szolikova, Zsolt Hascsi, Sandor Barna, Antonietta Acs, Peter Szabo, Lajos Tron, Laszlo Balkay, Magnus Dahlbom, Mihaly Zentai, Attila Forgacs and Ildiko Garai Tags: Original research Source Type: research
Influence of dosimetry method on bone lesion absorbed dose estimates in PSMA therapy: application to mCRPC patients receiving Lu-177-PSMA-I & T
Patients with metastatic, castration-resistant prostate cancer (mCRPC) present with an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) radioligand therapy targeting the prosta... (Source: EJNMMI Physics)
Source: EJNMMI Physics - March 12, 2021 Category: Radiology Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido B öning Tags: Original research Source Type: research
