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Vaccination: Cancer Vaccines
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Total 7677 results found since Jan 2013.
Natural and synthetic drugs and formulations for intravaginal HPV clearance
CONCLUSIONS: This article may serve as a valuable resource of information for managing and preventing precancerous carcinogenic HPV infections. Research could be directed toward developing candidate drugs to make evidence-based decisions about advancing them to clinical trials and, eventually, to the market for potential use in the prevention and control of cervical cancer, which is almost always preventable or even curable if detected early.PMID:37535995 | DOI:10.1016/j.jiph.2023.06.016
Source: Cancer Control - August 3, 2023 Category: Cancer & Oncology Authors: Nizar A Khamjan Saba Beigh Abdullah Algaissi Kanu Megha Mohtashim Lohani Majid Darraj Nader Kamli Faisal Madkhali Sajad Ahmad Dar Source Type: research
Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway
Biomaterials. 2023 Jul 28;301:122259. doi: 10.1016/j.biomaterials.2023.122259. Online ahead of print.ABSTRACTDue to the immunosuppressive tumor microenvironment (ITM) resulting from tumor-associated macrophages (TAMs) and regulatory T cells, immune checkpoint blockade and vaccine therapies often lead to an inadequate immune response. Recently, cyclic guanosine monophosphate-adenosine monophosphate synthase/stimulator of interferon gene (cGAS/STING)-mediated innate immunity has emerged as a promising cancer therapeutic, as STING pathway activation could promote dendritic cells (DCs) maturation and tumor-specific cytotoxic T...
Source: Biomaterials - August 2, 2023 Category: Materials Science Authors: Lili Cheng Peng Zhang Yadong Liu Zhuoyin Liu Junjie Tang Langtao Xu Jie Liu Source Type: research
Racial, Ethnic, and Gender Differences in the Timing of Initiating the HPV Vaccine in the United States: the Case of Southeast Asian Americans
J Racial Ethn Health Disparities. 2023 Aug 2. doi: 10.1007/s40615-023-01689-0. Online ahead of print.ABSTRACTDespite the availability of the human papillomavirus (HPV) vaccine, non-Latinx (NL) Southeast Asian Americans have the highest incidence of HPV-associated cervical cancer in the US. Little is known about NL-Southeast Asian Americans' HPV vaccination coverage due to being categorized under the "Asian American" monolith. Therefore, this study uses restricted data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES) to disaggregate NL-Southeast Asian Americans and compare this population's age-s...
Source: Cancer Control - August 2, 2023 Category: Cancer & Oncology Authors: Kim-Phuong Truong-Vu Source Type: research
Frequency of vaccine hesitancy among patients with advanced cancer
This study was a prospective cross-sectional survey trial conducted from March 10, 2022, to November 1, 2022, at a Supportive Care Clinic. Patients completed the survey with a research assistant or from a survey link. Vaccine hesitancy was defined as a response of 2 or more on the Parent Attitudes About Childhood Vaccines (PACV-4). Perception on vaccine safety and efficacy along with the importance of sources of information were determined by a questionnaire.RESULTS: Of the 72 patients who completed the PACV-4, 30 were considered vaccine-hesitant (42%). Of those who completed the survey alone (35), 23 (66%) were vaccine-he...
Source: Palliative and Supportive Care - August 1, 2023 Category: Palliative Care Authors: Michael Tang Yvonne Heung Bryan Fellman Eduardo Bruera Source Type: research
Monitoring, prophylaxis, and treatment of infections in patients with MM receiving bispecific antibody therapy: consensus recommendations from an expert panel
Blood Cancer J. 2023 Aug 1;13(1):116. doi: 10.1038/s41408-023-00879-7.ABSTRACTBispecific antibodies (BsAbs) are emerging as an important novel class of immunotherapeutic agents for the treatment of multiple myeloma (MM), and are set to be more widely used in clinical practice. However, this new class of therapies is associated with a distinct adverse event (AE) profile that includes cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, as well as AEs leading to increased infection risk such as cytopenias and hypogammaglobulinemia, and infections themselves. As preliminary data with this clas...
Source: Herpes - August 1, 2023 Category: Infectious Diseases Authors: Noopur Raje Kenneth Anderson Hermann Einsele Yvonne Efebera Francesca Gay Sarah P Hammond Alexander M Lesokhin Sagar Lonial Heinz Ludwig Philippe Moreau Krina Patel Karthik Ramasamy Maria-Victoria Mateos Source Type: research
Frequency of vaccine hesitancy among patients with advanced cancer
This study was a prospective cross-sectional survey trial conducted from March 10, 2022, to November 1, 2022, at a Supportive Care Clinic. Patients completed the survey with a research assistant or from a survey link. Vaccine hesitancy was defined as a response of 2 or more on the Parent Attitudes About Childhood Vaccines (PACV-4). Perception on vaccine safety and efficacy along with the importance of sources of information were determined by a questionnaire.RESULTS: Of the 72 patients who completed the PACV-4, 30 were considered vaccine-hesitant (42%). Of those who completed the survey alone (35), 23 (66%) were vaccine-he...
Source: Palliative and Supportive Care - August 1, 2023 Category: Palliative Care Authors: Michael Tang Yvonne Heung Bryan Fellman Eduardo Bruera Source Type: research
Liquid nitrogen frozen cells for chemotherapy drug delivery and vaccination of melanoma
CONCLUSION: In this work, we obtain the LNF cells with a simple procedure. The LNF cells not only provides a tumor cells-based multi-modal system for cancer therapy but inspires new insights into future development of individualized CVs strategies. This study processes live B16F10 cells by liquid nitrogen frozen to obtain LNF cells, which preserve cell integrity and homologous targeting ability. The LNF cells can load and deliver drug and can serve as tumor vaccine. Results demonstrated the LNF cells have effective prophylactic ability, and ideal anti-tumor ability with the loaded drug and adjuvant.PMID:37522925 | DOI:10.1...
Source: Cancer Control - July 31, 2023 Category: Cancer & Oncology Authors: Minliang Wu Yuai Xiao Jianguo Huang Yuchong Wang Yifan Zhang Jianguo Xu Haiying Dai Chuan Lv Yihui Hu Bingdi Chen Qingge Fu Wenjun Le Chunyu Xue Source Type: research
Novel phenanthrene imidazoles as telomeric G-quadruplex ligands trigger potent immunogenic cell death in triple-negative breast cancer
In this study, we rationally designed and synthesized a series of novel phenanthrene imidazoles targeting telomeric G4. Among them, PI-2 was identified as the most promising ligand with high cytotoxicity, cellular uptake efficiency and G4-interacting ability. Cellular studies indicated that PI-2 inhibited the proliferation and migration of both human and mouse triple-negative breast cancer (TNBC) cells. PI-2 triggered the occurrence of DDR and ICD, where the related pathways were further decided. In vivo experiments displayed that PI-2-treated dying cells could be an effective vaccination to reduce tumor burden and promote...
Source: International Journal of Biological Macromolecules - July 31, 2023 Category: Biochemistry Authors: Xiao-Dong Wang Jia-Xin Wang Ming-Hao Hu Source Type: research
Liquid nitrogen frozen cells for chemotherapy drug delivery and vaccination of melanoma
CONCLUSION: In this work, we obtain the LNF cells with a simple procedure. The LNF cells not only provides a tumor cells-based multi-modal system for cancer therapy but inspires new insights into future development of individualized CVs strategies. This study processes live B16F10 cells by liquid nitrogen frozen to obtain LNF cells, which preserve cell integrity and homologous targeting ability. The LNF cells can load and deliver drug and can serve as tumor vaccine. Results demonstrated the LNF cells have effective prophylactic ability, and ideal anti-tumor ability with the loaded drug and adjuvant.PMID:37522925 | DOI:10.1...
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Minliang Wu Yuai Xiao Jianguo Huang Yuchong Wang Yifan Zhang Jianguo Xu Haiying Dai Chuan Lv Yihui Hu Bingdi Chen Qingge Fu Wenjun Le Chunyu Xue Source Type: research
Analysis of hepatocellular carcinoma associated with hepatitis B virus
J Cell Mol Med. 2023 Jul 30. doi: 10.1111/jcmm.17867. Online ahead of print.ABSTRACTThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems...
Source: J Cell Mol Med - July 30, 2023 Category: Molecular Biology Authors: Litao Zheng Source Type: research
