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Vaccination: Cancer Vaccines
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Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
