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Vaccination: Cancer Vaccines
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Total 7677 results found since Jan 2013.
Comparison of awareness, attitudes and knowledge on human papilloma virus vaccination in Singapore: 2019 versus 2013
CONCLUSION: The Singapore government's efforts to improve cervical cancer awareness through national campaigns and policy changes have led to an improvement in knowledge of HPV infection. However, this has not translated into improvements in the vaccine acceptance rates. The decision for vaccine uptake is complex, and there are multiple factors to be addressed to ensure cost-effective implementation of the strategies. Our study highlights the need for effective dissemination of vaccine information, additional subsidies and consideration of a mandatory school-based vaccination programme.PMID:37675669 | DOI:10.4103/singaporemedj.SMJ-2020-437
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Michelle E-Jyn Kwek Joella Xiaohong Ang Manisha Mathur Lily Chye Lee Kho Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
Comparison of awareness, attitudes and knowledge on human papilloma virus vaccination in Singapore: 2019 versus 2013
CONCLUSION: The Singapore government's efforts to improve cervical cancer awareness through national campaigns and policy changes have led to an improvement in knowledge of HPV infection. However, this has not translated into improvements in the vaccine acceptance rates. The decision for vaccine uptake is complex, and there are multiple factors to be addressed to ensure cost-effective implementation of the strategies. Our study highlights the need for effective dissemination of vaccine information, additional subsidies and consideration of a mandatory school-based vaccination programme.PMID:37675669 | DOI:10.4103/singaporemedj.SMJ-2020-437
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Michelle E-Jyn Kwek Joella Xiaohong Ang Manisha Mathur Lily Chye Lee Kho Source Type: research
Provision of screening services for cervical and breast cancer - A scientific study commissioned by the European Board & amp; College of Obstetrics and Gynaecology (EBCOG)
CONCLUSIONS: There are discrepancies around gynaecological cancer screenings provision among EBCOG member countries. It is important to establish European recommendations about screening for gynaecological cancers, in order to standardize the access to equitable better health care in gynaecological cancers within Europe.PMID:37679212 | DOI:10.1016/j.ejogrb.2023.08.385
Source: Reproductive Biology - September 7, 2023 Category: Reproduction Medicine Authors: M árcia Vieira-Coimbra Nuno Nogueira-Martins Rafal Zadykowicz Hugo Rodrigues Gaspar Jean Calleja-Agius Maja Pakiz Sambit Mukhopadhyay Tahir Mahmood Source Type: research
Comparison of awareness, attitudes and knowledge on human papilloma virus vaccination in Singapore: 2019 versus 2013
CONCLUSION: The Singapore government's efforts to improve cervical cancer awareness through national campaigns and policy changes have led to an improvement in knowledge of HPV infection. However, this has not translated into improvements in the vaccine acceptance rates. The decision for vaccine uptake is complex, and there are multiple factors to be addressed to ensure cost-effective implementation of the strategies. Our study highlights the need for effective dissemination of vaccine information, additional subsidies and consideration of a mandatory school-based vaccination programme.PMID:37675669 | DOI:10.4103/singaporemedj.SMJ-2020-437
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Michelle E-Jyn Kwek Joella Xiaohong Ang Manisha Mathur Lily Chye Lee Kho Source Type: research
Provision of screening services for cervical and breast cancer - A scientific study commissioned by the European Board & amp; College of Obstetrics and Gynaecology (EBCOG)
CONCLUSIONS: There are discrepancies around gynaecological cancer screenings provision among EBCOG member countries. It is important to establish European recommendations about screening for gynaecological cancers, in order to standardize the access to equitable better health care in gynaecological cancers within Europe.PMID:37679212 | DOI:10.1016/j.ejogrb.2023.08.385
Source: Reproductive Biology - September 7, 2023 Category: Reproduction Medicine Authors: M árcia Vieira-Coimbra Nuno Nogueira-Martins Rafal Zadykowicz Hugo Rodrigues Gaspar Jean Calleja-Agius Maja Pakiz Sambit Mukhopadhyay Tahir Mahmood Source Type: research
Comparison of awareness, attitudes and knowledge on human papilloma virus vaccination in Singapore: 2019 versus 2013
CONCLUSION: The Singapore government's efforts to improve cervical cancer awareness through national campaigns and policy changes have led to an improvement in knowledge of HPV infection. However, this has not translated into improvements in the vaccine acceptance rates. The decision for vaccine uptake is complex, and there are multiple factors to be addressed to ensure cost-effective implementation of the strategies. Our study highlights the need for effective dissemination of vaccine information, additional subsidies and consideration of a mandatory school-based vaccination programme.PMID:37675669 | DOI:10.4103/singaporemedj.SMJ-2020-437
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Michelle E-Jyn Kwek Joella Xiaohong Ang Manisha Mathur Lily Chye Lee Kho Source Type: research
Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine
EMBO Mol Med. 2023 Sep 7:e17723. doi: 10.15252/emmm.202317723. Online ahead of print.ABSTRACTHuman papillomavirus (HPV) infections are the cause of all cervical and numerous oropharyngeal and anogenital cancers. The currently available HPV vaccines, which induce neutralizing antibodies, have no therapeutic effect on established tumors. Here, we developed an immuno-oncotherapy against HPV-induced tumors based on a non-integrative lentiviral vector encoding detoxified forms of the Early E6 and E7 oncoproteins of HPV16 and 18 genotypes, namely, "Lenti-HPV-07". A single intramuscular injection of Lenti-HPV-07 into mice bearing...
Source: Molecular Medicine - September 7, 2023 Category: Molecular Biology Authors: La ëtitia Douguet Ingrid Fert Jodie Lopez Benjamin Vesin Fabien Le Chevalier Fanny Moncoq Pierre Authi é Trang-My Nguyen Amandine Noirat Fabien N évo Catherine Blanc Maryline Bourgine David Hardy Fran çois Anna Laleh Majlessi Pierre Charneau Source Type: research
DeepMHCI: An anchor position-aware deep interaction model for accurate MHC-I peptide binding affinity prediction
Bioinformatics. 2023 Sep 5:btad551. doi: 10.1093/bioinformatics/btad551. Online ahead of print.ABSTRACTMOTIVATION: Computationally predicting MHC-I peptide binding affinity is an important problem in immunological bioinformatics, which is also crucial for the identification of neoantigens for personalized therapeutic cancer vaccines. Recent cutting-edge deep learning-based methods for this problem cannot achieve satisfactory performance, especially for non-9-mer peptides. This is because such methods generate the input by simply concatenating the two given sequences: a peptide and (the pseudo sequence of) an MHC class I mo...
Source: Cancer Control - September 5, 2023 Category: Cancer & Oncology Authors: Wei Qu Ronghui You Hiroshi Mamitsuka Shanfeng Zhu Source Type: research
Memory T Cells in the Immunoprevention of Cancer: A Switch from Therapeutic to Prophylactic Approaches
J Immunol. 2023 Sep 15;211(6):907-916. doi: 10.4049/jimmunol.2300049.ABSTRACTCancer immunoprevention, the engagement of the immune system to prevent cancer, is largely overshadowed by therapeutic approaches to treating cancer after detection. Vaccines or, alternatively, the utilization of genetically engineered memory T cells could be methods of engaging and creating cancer-specific T cells with superb memory, lenient activation requirements, potent antitumor cytotoxicity, tumor surveillance, and resilience against immunosuppressive factors in the tumor microenvironment. In this review we analyze memory T cell subtypes bas...
Source: Journal of Immunology - September 5, 2023 Category: Allergy & Immunology Authors: Siddhesh Mittra Shane M Harding Susan M Kaech Source Type: research
PepAnalyzer: predicting peptide properties using its sequence
Amino Acids. 2023 Sep 5. doi: 10.1007/s00726-023-03317-x. Online ahead of print.ABSTRACTPeptides are short linear molecules consisting of amino acids that play an essential role in most biological processes. They can treat diseases by working as a vaccine or antimicrobial agent and serves as a cancer molecule to deliver the drug to the target site for the treatment of cancer. They have the potential to solve the drawbacks of current medications and can be industrially produced in large quantities at low cost. However, poor chemical and physical stability, short circulating plasma half-life, and solubility are some issues t...
Source: Amino Acids - September 5, 2023 Category: Biochemistry Authors: Vanshika Rustagi Shradheya R R Gupta Monika Bajaj Archana Singh Indrakant Kumar Singh Source Type: research
