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Vaccination: Cancer Vaccines
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Total 7677 results found since Jan 2013.
Tumor vaccine based on extracellular vesicles derived from γδ-T cells exerts dual antitumor activities
This study provides a proof-of-concept for using the allogeneic γδ-T-EVs-based vaccine in cancer control.PMID:37654012 | DOI:10.1002/jev2.12360
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Xiwei Wang Yanmei Zhang Yuet Chung Chloe Ran Tu Wenyue Zhang Xiaofeng Mu Manni Wang Godfrey Chi-Fung Chan Wing-Hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu Source Type: research
N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA
Eur Biophys J. 2023 Sep 1. doi: 10.1007/s00249-023-01676-7. Online ahead of print.ABSTRACTIn recent years many scientists have begun to focus on the mRNA molecule's emeregence as a new type of drug. Its fast-moving and successful career as a vaccine technology cannot be underestimated. mRNA provides new opportunities and allows for the rapid preparation of effective drugs at low cost. These extensive possibilities stem from a number of factors, but the small cap structure located at the 5' end of the mRNA is one contributing factor. Cap protects mRNA and ensures efficient recruitment to the biosynthesis machinery. Furtherm...
Source: European Biophysics Journal : EBJ - September 1, 2023 Category: Physics Authors: Karol Kurpiejewski Marzena Jankowska-Anyszka Renata Grzela Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
Real-world challenges in eligibility for MMR vaccination two years after autologous and allogeneic HSCT
Vaccine. 2023 Aug 29:S0264-410X(23)00778-8. doi: 10.1016/j.vaccine.2023.06.075. Online ahead of print.ABSTRACTMeasles outbreaks have raised concerns of fatal infections in immunocompromised patients. Canadian guidelines advise administration of live vaccines, such as measles, mumps, and rubella (MMR), two yearsafter hematopoietic stem cell transplant (HSCT) yet studies have not assessed eligibility based on medication contraindications. We retrospectively reviewed the charts of 72 autologous (auto-HSCT) and 68 allogeneic (allo-HSCT) recipients at the Windsor Regional Cancer Center to determine MMR reactivity and eligibilit...
Source: Vaccine - August 31, 2023 Category: Allergy & Immunology Authors: Gopika Punchhi Rainbow Negus Hammad Saif Sharon Pritchard Olivia Owen Aman Sehmbi Caroline Hamm Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
Real-world challenges in eligibility for MMR vaccination two years after autologous and allogeneic HSCT
Vaccine. 2023 Aug 29:S0264-410X(23)00778-8. doi: 10.1016/j.vaccine.2023.06.075. Online ahead of print.ABSTRACTMeasles outbreaks have raised concerns of fatal infections in immunocompromised patients. Canadian guidelines advise administration of live vaccines, such as measles, mumps, and rubella (MMR), two yearsafter hematopoietic stem cell transplant (HSCT) yet studies have not assessed eligibility based on medication contraindications. We retrospectively reviewed the charts of 72 autologous (auto-HSCT) and 68 allogeneic (allo-HSCT) recipients at the Windsor Regional Cancer Center to determine MMR reactivity and eligibilit...
Source: Vaccine - August 31, 2023 Category: Allergy & Immunology Authors: Gopika Punchhi Rainbow Negus Hammad Saif Sharon Pritchard Olivia Owen Aman Sehmbi Caroline Hamm Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
Turning anecdotal irradiation-induced anti-cancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells
In conclusion, our novel approach generated an anti-cancer immune response, resulting in a lack of or low tumor incidence post-rechallenge and robust AEs, i.e., the absence of or decreased spontaneous lung metastasis in tumor-bearing mice. This approach is readily translatable to clinical settings and may increase IR-induced AEs in cancer patients.PMID:37645899 | PMC:PMC10462241 | DOI:10.21203/rs.3.rs-3195392/v1
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Xinhui Wang Wei Guo Lin Jia Ling Xie Juliann Kiang Yangyang Wang Fuyou Wang Zunwen Lin Enwen Wang Yida Zhang Peigen Huang Ting Sun Xiao Zhang Zhengying Bian Tiejun Tang Jingtian Guo Soldano Ferrone Source Type: research
