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Vaccination: Cancer Vaccines
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Current progress in pharmacokinetic studies of vaccines: Impact of carrier, ADME and its modulation on immune responses
Environ Res. 2023 Aug 3:116823. doi: 10.1016/j.envres.2023.116823. Online ahead of print.ABSTRACTThe lack of knowledge about the absorption, distribution, metabolism, and excretion (ADME) of vaccines makes biopharmaceutical optimization difficult. This was shown during the COVID-19 immunization campaign, where gradual booster doses were introduced as the initial dose was not offering broad protection against infection. Thus, understanding vaccine ADME and its effects on immunization effectiveness could result in a more logical vaccine design in terms of formulation, method of administration, and dosing regimens. Herein, we...
Source: Environmental Research - August 5, 2023 Category: Environmental Health Authors: Saurav Kumar Jha Mohammad Imran Laxmi Akhileshwar Jha Nazeer Hasan Vijay Kumar Panthi Keshav Raj Paudel Waleed H Almalki Yousuf Mohammed Prashant Kesharwani Source Type: research
Applying the COM-B behaviour model to understand factors which impact school immunisation nurses' attitudes towards designing and delivering a HPV educational intervention in post-primary schools for 15-17 year old students in Northern Ireland, UK
CONCLUSION: IMNs feel that they are the most appropriate professionals to design/deliver HPV education for 15-17 year old students. National policy change, based on collaboration between the Public Health Agency and Education Authority, is a key factor in facilitating IMNs to implement this school-based HPV education intervention.PMID:37543445 | DOI:10.1016/j.vaccine.2023.07.066
Source: Vaccine - August 5, 2023 Category: Allergy & Immunology Authors: Terri Flood Marian McLaughlin Ciara M Hughes Iseult M Wilson Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Kenneth Lundstrom Source Type: research
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: Mol Biol Cell - August 4, 2023 Category: Molecular Biology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: Mol Biol Cell - August 4, 2023 Category: Molecular Biology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: Mol Biol Cell - August 4, 2023 Category: Molecular Biology Authors: Kenneth Lundstrom Source Type: research
Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of Anal Intraepithelial Neoplasia in HIV+ Men
CONCLUSIONS: The highest dose level is safe, immunogenic and associated with clinical responses to HPV16-induced lesions. However, as the majority of HGAIN is caused by the other HPV types, further studies should aim at pan-HPV vaccination to prevent or treat HGAIN.PMID:37540563 | DOI:10.1158/1078-0432.CCR-22-3361
Source: Clinical Cancer Research - August 4, 2023 Category: Cancer & Oncology Authors: Karien C M Gosens Sjoerd H van der Burg Marij J P Welters Sanne Boekestijn Nikki M Loof Wim G V Quint Carel J M van Noesel Allard C van der Wal Olivier Richel Wilhelmus J T A Krebber Cornelis J M Melief Henry J C de Vries Jan M Prins Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Kenneth Lundstrom Source Type: research
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Armored modified vaccinia Ankara in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:87-142. doi: 10.1016/bs.ircmb.2023.05.003. Epub 2023 May 31.ABSTRACTCancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviru...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Cigdem Atay Jos é Medina-Echeverz Hubertus Hochrein Mark Suter Maria Hinterberger Source Type: research
Alphaviruses in cancer immunotherapy
Int Rev Cell Mol Biol. 2023;379:143-168. doi: 10.1016/bs.ircmb.2023.03.011. Epub 2023 Jun 14.ABSTRACTAlphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells. Alphavirus vectors can be used as recombinant viral particles or oncolytic viruses. Alternatively, either naked or nanoparticle-encapsulated RNA and DNA replicons can be utilized. In the context of cancer prevention and treatment, antitumor...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
