Liquid nitrogen frozen cells for chemotherapy drug delivery and vaccination of melanoma

CONCLUSION: In this work, we obtain the LNF cells with a simple procedure. The LNF cells not only provides a tumor cells-based multi-modal system for cancer therapy but inspires new insights into future development of individualized CVs strategies. This study processes live B16F10 cells by liquid nitrogen frozen to obtain LNF cells, which preserve cell integrity and homologous targeting ability. The LNF cells can load and deliver drug and can serve as tumor vaccine. Results demonstrated the LNF cells have effective prophylactic ability, and ideal anti-tumor ability with the loaded drug and adjuvant.PMID:37522925 | DOI:10.1007/s00432-023-05117-y

Source: Cancer Control - July 31, 2023 Category: Cancer & Oncology Authors: Minliang Wu Yuai Xiao Jianguo Huang Yuchong Wang Yifan Zhang Jianguo Xu Haiying Dai Chuan Lv Yihui Hu Bingdi Chen Qingge Fu Wenjun Le Chunyu Xue Source Type: research