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Breast cancer immunotherapy: a comprehensive review
Clin Exp Med. 2023 Sep 1. doi: 10.1007/s10238-023-01177-z. Online ahead of print.ABSTRACTCancer remains a major health problem despite numerous new medical interventions that have been introduced in recent years. One of the major choices for cancer therapy is so-called adoptive cell therapy (ACT). ACT can be performed using both innate immune cells, including dendritic cells (DCs), natural killer (NK) cells, and γδ T cells and acquired immune T cells. It has become possible to utilize these cells in both their native and modified states in clinical studies. Because of considerable success in cancer treatment, ACT now pla...
Source: Clinical Genitourinary Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Samaneh Keshavarz Jack R Wall Somayeh Keshavarz Elham Vojoudi Reza Jafari-Shakib Source Type: research
Molecular dynamics simulation of the transmembrane transport process of reactive species under the synergistic effect of plasma oxidation and an electric field
Free Radic Biol Med. 2023 Aug 30:S0891-5849(23)00609-3. doi: 10.1016/j.freeradbiomed.2023.08.029. Online ahead of print.ABSTRACTCold atmospheric pressure plasma (CAP)-assisted cancer therapy has become a popular topic in plasma biomedical research. Membrane lipid oxidation and local electric fields are two important factors in plasma-cell interactions, and the study of their synergistic effect is highly significant for optimizing the regulatory mechanism of the plasma-induced apoptosis of cancer cells. In this paper, a model of oxidized phospholipids was established, and the transmembrane process of reactive species was si...
Source: Free Radical Biology and Medicine - September 1, 2023 Category: Biology Authors: Yanxiu Cui Tong Zhao Huichao Wang Xiaolong Wang Daohan Wang Yuantao Zhang Source Type: research
Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma
Curr Cancer Drug Targets. 2023;23(11):879-888. doi: 10.2174/1568009623666230503094346.ABSTRACTOne of the most important health problems in the world today is cancer. The World Health Organization (WHO) reported that it results in 8.9 million deaths annually. Malignant tumours and unregulated cell proliferation are features of malignant neoplasms, which can also invade nearby body regions. Hepatocellular carcinoma is the third most prevalent cause of cancer-related death worldwide and the fifth most common kind of cancer, according to a recent analysis. Patients with liver disease as well as chronic hepatitis B and C are mo...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Amrita Singh Sudhanshu Mishra Saurabh Sharma Smriti Ojha Sunil Yagnik Sudhi Pandey Source Type: research
Roles of salt ‑inducible kinases in cancer (Review)
Int J Oncol. 2023 Nov;63(5):118. doi: 10.3892/ijo.2023.5566. Epub 2023 Sep 1.ABSTRACTSalt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of cancers. Based on most...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Shenghui Feng Fangyi Wei Haoran Shi Shen Chen Bangqi Wang Deqiang Huang Lingyu Luo Source Type: research
Biomacromolecule-based nanocarrier strategies to deliver plant-derived bioactive components for cancer treatment: A recent review
Int J Biol Macromol. 2023 Aug 30:126623. doi: 10.1016/j.ijbiomac.2023.126623. Online ahead of print.ABSTRACTThe quest for safe chemotherapy has attracted researchers to explore anticancer potential of herbal medicines. Owing to upsurging evidence of herbal drug's beneficial effects, hopes are restored for augmenting survival rates in cancer patients. However, phytoconstituents confronted severe limitations in terms of poor absorption, low-stability, and low bioavailability. Along with toxicity issues associated with phytoconstituents, quality control and limited regulatory guidance also hinder the prevalence of herbal medi...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Bapi Gorain Varnita Karmakar Biswatrish Sarkar Monika Dwivedi Janelle Tsui Lyn Leong Jing Hen Toh Even Seah Kang Yi Ling Kah Yee Chen Hira Choudhury Manisha Pandey Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: Mol Biol Cell - September 1, 2023 Category: Molecular Biology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: Mol Biol Cell - September 1, 2023 Category: Molecular Biology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma
Curr Cancer Drug Targets. 2023;23(11):879-888. doi: 10.2174/1568009623666230503094346.ABSTRACTOne of the most important health problems in the world today is cancer. The World Health Organization (WHO) reported that it results in 8.9 million deaths annually. Malignant tumours and unregulated cell proliferation are features of malignant neoplasms, which can also invade nearby body regions. Hepatocellular carcinoma is the third most prevalent cause of cancer-related death worldwide and the fifth most common kind of cancer, according to a recent analysis. Patients with liver disease as well as chronic hepatitis B and C are mo...
Source: Current Cancer Drug Targets - September 1, 2023 Category: Cancer & Oncology Authors: Amrita Singh Sudhanshu Mishra Saurabh Sharma Smriti Ojha Sunil Yagnik Sudhi Pandey Source Type: research
Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy
Trends Genet. 2023 Aug 30:S0168-9525(23)00163-4. doi: 10.1016/j.tig.2023.07.005. Online ahead of print.ABSTRACTCancer treatment strategies have evolved significantly over the years, with chemotherapy, targeted therapy, and immunotherapy as major pillars. Each modality leads to unique treatment outcomes by interacting with the tumor microenvironment (TME), which imposes a fundamental selective pressure on cancer progression. The advent of single-cell profiling technologies has revolutionized our understanding of the intricate and heterogeneous nature of the TME at an unprecedented resolution. This review delves into the com...
Source: Trends in Genetics : TIG - September 1, 2023 Category: Genetics & Stem Cells Authors: Yikai Luo Han Liang Source Type: research
Molecular dynamics simulation of the transmembrane transport process of reactive species under the synergistic effect of plasma oxidation and an electric field
Free Radic Biol Med. 2023 Aug 30:S0891-5849(23)00609-3. doi: 10.1016/j.freeradbiomed.2023.08.029. Online ahead of print.ABSTRACTCold atmospheric pressure plasma (CAP)-assisted cancer therapy has become a popular topic in plasma biomedical research. Membrane lipid oxidation and local electric fields are two important factors in plasma-cell interactions, and the study of their synergistic effect is highly significant for optimizing the regulatory mechanism of the plasma-induced apoptosis of cancer cells. In this paper, a model of oxidized phospholipids was established, and the transmembrane process of reactive species was si...
Source: Free Radical Biology and Medicine - September 1, 2023 Category: Biology Authors: Yanxiu Cui Tong Zhao Huichao Wang Xiaolong Wang Daohan Wang Yuantao Zhang Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Sulfur dioxide-releasing polymeric micelles based on modified hyaluronic acid for combined cancer therapy
In this study, an amphiphilic polymer mPEG-HA(SA)-DNs was designed and synthesized to fabricate a multifunctional micellar system to enhance the therapeutic efficacy and reduce the toxic effect of paclitaxel (PTX). The polymer was prepared by introducing mPEG, stearic acid (SA) and 2,4-dinitrobenzenesulfonic acid (DNs) to the backbone of hyaluronic acid (HA). With above modifications, the fabricated micelles could encapsulate PTX in the core with high drug loading. The optimized PTX-loaded micelles had a mean size of 158.3 nm. Upon the effect of mPEG, the mPEG-HA(SA)-DNs micelles reduced the non-specific protein adsorption...
Source: International Journal of Biological Macromolecules - September 1, 2023 Category: Biochemistry Authors: Sheng Wang Shupeng Li Na Liang Siyi Li Xiaoxin Li Pengfei Yan Shaoping Sun Source Type: research
Biomacromolecule-based nanocarrier strategies to deliver plant-derived bioactive components for cancer treatment: A recent review
Int J Biol Macromol. 2023 Aug 30:126623. doi: 10.1016/j.ijbiomac.2023.126623. Online ahead of print.ABSTRACTThe quest for safe chemotherapy has attracted researchers to explore anticancer potential of herbal medicines. Owing to upsurging evidence of herbal drug's beneficial effects, hopes are restored for augmenting survival rates in cancer patients. However, phytoconstituents confronted severe limitations in terms of poor absorption, low-stability, and low bioavailability. Along with toxicity issues associated with phytoconstituents, quality control and limited regulatory guidance also hinder the prevalence of herbal medi...
Source: International Journal of Biological Macromolecules - September 1, 2023 Category: Biochemistry Authors: Bapi Gorain Varnita Karmakar Biswatrish Sarkar Monika Dwivedi Janelle Tsui Lyn Leong Jing Hen Toh Even Seah Kang Yi Ling Kah Yee Chen Hira Choudhury Manisha Pandey Source Type: research
Breast cancer immunotherapy: a comprehensive review
Clin Exp Med. 2023 Sep 1. doi: 10.1007/s10238-023-01177-z. Online ahead of print.ABSTRACTCancer remains a major health problem despite numerous new medical interventions that have been introduced in recent years. One of the major choices for cancer therapy is so-called adoptive cell therapy (ACT). ACT can be performed using both innate immune cells, including dendritic cells (DCs), natural killer (NK) cells, and γδ T cells and acquired immune T cells. It has become possible to utilize these cells in both their native and modified states in clinical studies. Because of considerable success in cancer treatment, ACT now pla...
Source: Clinical Breast Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Samaneh Keshavarz Jack R Wall Somayeh Keshavarz Elham Vojoudi Reza Jafari-Shakib Source Type: research
