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Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Roles of salt ‑inducible kinases in cancer (Review)
Int J Oncol. 2023 Nov;63(5):118. doi: 10.3892/ijo.2023.5566. Epub 2023 Sep 1.ABSTRACTSalt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of cancers. Based on most...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Shenghui Feng Fangyi Wei Haoran Shi Shen Chen Bangqi Wang Deqiang Huang Lingyu Luo Source Type: research
Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy
Trends Genet. 2023 Aug 30:S0168-9525(23)00163-4. doi: 10.1016/j.tig.2023.07.005. Online ahead of print.ABSTRACTCancer treatment strategies have evolved significantly over the years, with chemotherapy, targeted therapy, and immunotherapy as major pillars. Each modality leads to unique treatment outcomes by interacting with the tumor microenvironment (TME), which imposes a fundamental selective pressure on cancer progression. The advent of single-cell profiling technologies has revolutionized our understanding of the intricate and heterogeneous nature of the TME at an unprecedented resolution. This review delves into the com...
Source: Trends in Genetics : TIG - September 1, 2023 Category: Genetics & Stem Cells Authors: Yikai Luo Han Liang Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
