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Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Epigenetic inhibitors and their role in cancer therapy
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibi...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Synthesis and clinical application of small-molecule inhibitors and PROTACs of anaplastic lymphoma kinase
Bioorg Chem. 2023 Aug 25;140:106807. doi: 10.1016/j.bioorg.2023.106807. Online ahead of print.ABSTRACTPharmacological interventions that specifically target protein products of oncogenes in tumors have surfaced as a propitious therapeutic approach. Among infrequent genetic alterations, rearrangements of the anaplastic lymphoma kinase (ALK) gene, typically involving a chromosome 2 inversion that culminates in a fusion with the echinoderm microtubule-associated protein like 4 (EML4), lead to anomalous expression and activation of ALK. The inhibition of autophosphorylation and subsequent blockade of signal transduction by ALK...
Source: Bioorganic Chemistry - August 31, 2023 Category: Chemistry Authors: Hua Gao Jing-Yi Zhang Li-Jie Zhao Yuan-Yuan Guo Source Type: research
Mechanism of Quercetin as a Multidrug-resistant Reversing Compound in Oxaliplatin-resistant Gastric-cancer Cell Lines
CONCLUSIONS: Qur induced a dramatic reduction in the survival rate of KATOIII/OxR cells and may reverse OxR resistance through a decrease in P-gp expression and activity. These data imply that exposure of KATOIII/OxR cells in the dose-dependent manner to Qur can circumvent MDR by improving the intracellular accumulation of OxR. Qur might provide a new treatment strategy and improve patients' survival after chemotherapy for gastric cancer.PMID:37652429
Source: Alternative Therapies in Health and Medicine - August 31, 2023 Category: Complementary Medicine Authors: Guodong Zhao Siwei Xue Source Type: research
The Effects of Environmental Aryl Hydrocarbon Receptor Ligands on Signaling and Cell Metabolism in Cancer
Biochem Pharmacol. 2023 Aug 29:115771. doi: 10.1016/j.bcp.2023.115771. Online ahead of print.ABSTRACTDioxin and dioxin-like compounds are chlorinated organic pollutants formed during the manufacturing of other chemicals. Dioxins are ligands of the aryl hydrocarbon receptor (AHR), that induce AHR-mediated biochemical and toxic responses and are persistent in the environment. 2,3,7,8- tetrachlorodibenzo para dioxin (TCDD) is the prototypical AHR ligand and its effects represent dioxins. TCDD induces toxicity, immunosuppression and is a suspected tumor promoter. The role of TCDD in cancer however is debated and context-depend...
Source: Biochemical Pharmacology - August 31, 2023 Category: Drugs & Pharmacology Authors: Sean A Piwarski Travis B Salisbury Source Type: research
Comparison of PLLA-PEG and PDLLA-PEG micelles for co-encapsulation of docetaxel and resveratrol
This article presents a comparison of single- (Dtx or Res) and dual-drug (Dtx and Res) loaded micelles obtained from poly(l,l-lactide)-co-poly(ethylene glycol) (PLLA-PEG) and poly(d,l-lactide)-co-poly(ethylene glycol) (PDLLA-PEG). The analyzes of the micelles have been conducted including morphology, drug(s) encapsulation efficiency, intermolecular interactions, in vitro drug release, and cytotoxicity. Differences in drug loading ability and release profile have been observed between Res and Dtx but also depending on the polymer and number of drugs in micelles (single vs. dual loaded). The PLLA-PEG micelles have a signific...
Source: Biomed Res - August 31, 2023 Category: Research Authors: Magdalena Jurczyk Monika Musia ł-Kulik Aleksander Fory ś Marcin Godzierz Bo żena Kaczmarczyk Janusz Kasperczyk Dorota Wrze śniok Artur Beberok Katarzyna Jelonek Source Type: research
