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Total 13617 results found since Jan 2013.

Recent advances in small molecule and peptide inhibitors of glucose-regulated protein 78 for cancer therapy
Eur J Med Chem. 2023 Sep 4;261:115792. doi: 10.1016/j.ejmech.2023.115792. Online ahead of print.ABSTRACTGlucose-regulated protein 78 (GRP78) is one of key endoplasmic reticulum (ER) chaperone proteins that regulates the unfolded protein response (UPR) to maintain ER homeostasis. As a core factor in the regulation of the UPR, GRP78 takes a critical part in the cellular processes required for tumorigenesis, such as proliferation, metastasis, anti-apoptosis, immune escape and chemoresistance. Overexpression of GRP78 is closely correlated with tumorigenesis and poor prognosis in various malignant tumors. Targeting GRP78 is reg...
Source: European Journal of Medicinal Chemistry - September 10, 2023 Category: Chemistry Authors: Weikai Guo Manjie Wang Zhengfan Yang Danyang Liu Borui Ma Yanqun Zhao Yihua Chen Yanzhong Hu Source Type: research

Geographic Disparity of Outcome in Patients With Cancer Over Decades: The Surveillance, Epidemiology, and End Results
CONCLUSIONS: Significant disparities in cancer care exist among geographic locations. Geographic differences in survival appear more prominent when highly effective therapies are available.PMID:37690903 | DOI:10.1016/j.clml.2023.08.001
Source: Clinical Lymphoma and Myeloma - September 10, 2023 Category: Cancer & Oncology Authors: Koji Sasaki Kiyomi Morita Hagop Kantarjian Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Marina Konopleva Gautam Borthakur William Wierda Naval Daver Koichi Takahashi Courtney DiNardo Guillermo Montalban Bravo Ghayas C Issa Sherry A Pierce Kelly A Source Type: research

High BMP7 expression is associated with poor prognosis in ovarian cancer
J Cell Mol Med. 2023 Sep 8. doi: 10.1111/jcmm.17951. Online ahead of print.ABSTRACTBone Morphogenetic Protein 7 (BMP7) is an extracellular signalling protein that belongs to the transforming growth factor-β (TGF- β) superfamily. Previous transcriptomic data suggested that BMP7 expression may be disrupted in ovarian carcinoma and may play an important role in the aggressiveness of the disease. However, the protein expression in patient tumours has not been well studied. The current study aimed to assess BMP7 protein expression in a large cohort of ovarian carcinoma patient tumour samples to establish its associations with...
Source: Molecular Medicine - September 9, 2023 Category: Molecular Biology Authors: Richa Vasan Jahnavi Yadav Radhika Aiyappa-Maudsley Suha Deen Sarah J Storr Stewart G Martin Source Type: research

AI-2 quorum sensing controlled delivery of cytolysin-A by tryptophan auxotrophic low-endotoxic Salmonella and its anticancer effects in CT26 mice with colon cancer
CONCLUSION: Hence, the anti-tumor effect of the engineered Salmonella strain was improved by ClyA expression via QS activation after achieving the threshold bacterial cell density. Further, immunohistochemical staining of the tumor and other organs corroborated the QS-controlled tumor-specific expression of ClyA. Overall, the results imply that the developed anti-cancer Salmonella has low endotoxicity and QS-controlled expression of ClyA as beneficial safety elements and supports recurrent Salmonella inoculation by O-antigen deficiency.PMID:37689243 | DOI:10.1016/j.jare.2023.09.003
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Ram Prasad Aganja Chandran Sivasankar John Hwa Lee Source Type: research

Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using < em > Perilla frutescens < /em > Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells
In this study, we also explained the plausible mechanisms of the biosynthesis, anticancer, and antibacterial effects of PFFE-AgNPs. Overall, these findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, particularly in cancer therapy and infection control. However, it is important to note that further research is needed to determine the safety and efficacy of these nanoparticles in vivo, as well as to explore their potential in other areas of medicine.PMID:37687260 | DOI:10.3390/molecules28176431
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Tianyu Hou Yurong Guo Wanyu Han Yang Zhou Vasudeva Reddy Netala Huizhen Li He Li Zhijun Zhang Source Type: research

Viruses, Vol. 15, Pages 1903: Progress on Phage Display Technology: Tailoring Antibodies for Cancer Immunotherapy
roz Maranhão The search for innovative anti-cancer drugs remains a challenge. Over the past three decades, antibodies have emerged as an essential asset in successful cancer therapy. The major obstacle in developing anti-cancer antibodies is the need for non-immunogenic antibodies against human antigens. This unique requirement highlights a disadvantage to using traditional hybridoma technology and thus demands alternative approaches, such as humanizing murine monoclonal antibodies. To overcome these hurdles, human monoclonal antibodies can be obtained directly from Phage Display libraries, a groundbreaking tool for a...
Source: Viruses - September 9, 2023 Category: Virology Authors: Renato Kaylan Alves Fran ça Igor Cabral Studart Marcus Rafael Lobo Bezerra Larissa Queiroz Pontes Antonio Marcos Aires Barbosa Marcelo Macedo Brigido Gilvan Pessoa Furtado Andr éa Queiroz Maranhão Tags: Review Source Type: research

Silica-Based Platform Decorated with Conjugated Polymer Dots and Prussian Blue for Improved Photodynamic Cancer Therapy
ACS Appl Mater Interfaces. 2023 Sep 8. doi: 10.1021/acsami.3c08404. Online ahead of print.ABSTRACTTo advance cancer treatment, we have developed a novel composite material consisting of conjugated polymer dots (CPDs) and Prussian blue (PB) particles, which were immobilized on, and encapsulated within, silica particles, respectively. The CPDs functioned as both a photosensitizer and a photodynamic agent, and the PB acted as a photothermal agent. The silica platform provided a biocompatible matrix that brought the two components into close proximity. Under laser irradiation, the fluorescence from the CPDs in the composite ma...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Seonyoung Jo Hyeonhee Lee Ji Hwan Park Jin-Kyoung Yang Won-Jong Lee Jongchul Lim Sehoon Kim Soojin Lee Taek Seung Lee Source Type: research

Impact of a mental training program for pediatric cancer patients after allogeneic hematopoietic stem cell transplantation or high-dose chemotherapy - Results of a randomized controlled trial
Palliat Support Care. 2023 Sep 8:1-8. doi: 10.1017/S1478951523000986. Online ahead of print.ABSTRACTOBJECTIVES: Hematopoietic stem cell transplantation (HSCT) or intensive chemotherapy for the treatment of malignant diseases is a highly distressing experience. The affected person's resilience is crucial to coping with this challenging experience. Experience with resilience-enhancing interventions in children and young adults during cancer therapy is scarce. The major objective of this work was developing and evaluating an effective psycho-oncological mental training that complements the standard psychosocial care.METHODS: ...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Michaela D öring Johanna Xemaire Dustin Werle Stefanie Thiel Veronika Schneider Sebastian Michaelis Manuel Schl össer Peter Lang Jennifer Svaldi Karin Melanie Cabanillas Stanchi Source Type: research

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