Epigenetic inhibitors and their role in cancer therapy

Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.ABSTRACTEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibitors attenuate the abnormal epigenetic modifications in cancer cells and therefore have strong potential for cancer treatment. In this chapter, we have highlighted various types of epigenetic modifications, their mechanism, and as drug targets for epigenetic therapy.PMID:37657859 | DOI:10.1016/bs.ircmb.2023.04.005

Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Nouha Abdelaziz Lubna Therachiyil Hana Q Sadida Ateeque Mohamed Ali Omar S Khan Mayank Singh Abdul Q Khan Ammira S Al-Shabeeb Akil Ajaz A Bhat Shahab Uddin Source Type: research