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Cancer: Prostate Cancer
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Total 25217 results found since Jan 2013.
Relationship between seminal vesicle displacement and distribution of hydrogel spacer within the perirectal space in prostate radiotherapy
In conclusion, SV cranial displacement was influenced by HS lateral distribution of ≥1.00 cm in the upper two slices. Therefore, when the sigmoid colon or small bowel is depressed in rectovesical excavation and SV needs to be included in the target volume, HS insertion should be performed carefully.PMID:37719041 | PMC:PMC10502802 | DOI:10.3892/mco.2023.2674
Source: Clinical Prostate Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Kenji Makita Yasushi Hamamoto Hiromitsu Kanzaki Kei Nagasaki Katsuyoshi Hashine Source Type: research
mpMRI-targeted biopsy of the prostate in men ≥ 75 years. 7-year report from a high-volume referral center
CONCLUSION: After evaluation of a large patient cohort, we show that age≥75 years represents a significant risk factor for the detection of clinically significant prostate cancer. Further studies on mid- and long term outcome are necessary to draw conclusions for clinical decision making in this patient cohort.PMID:37718788 | DOI:10.3233/CH-238101
Source: Clinical Prostate Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Michael Chaloupka Nikolaos Pyrgidis Benedikt Ebner Paulo Pfitzinger Yannic Volz Elena Berg Benazir Abrarova Michael Atzler Troya Ivanova Paulo Pfitzinger Christian G Stief Maria Apfelbeck Dirk-Andr é Clevert Source Type: research
Dosimetric impact of MLC positional errors on dose distribution in IMRT
This study investigates dose sensitivity variations and complexity metrics of MLC positional error in volumetric modulated arc therapy and determines the acceptable ranges of MLC positional accuracy in several clinical situations. Treatment plans were generated for four treatment sites (prostate cancer, lung cancer, spinal, and brain metastases) using different treatment planning systems (TPSs) and fraction sizes. Each treatment plan introduced 0.25-2.0 mm systematic or random MLC leaf bank errors. The generalized equivalent uniform dose (gEUD) sensitivity and complexity metrics (MU/Gy and plan irregularity) were calculate...
Source: Clinical Lung Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Hiromi Enomoto Yukio Fujita Saki Matsumoto Yujiro Nakajima Miyuki Nagai Ayako Tonari Takeshi Ebara Source Type: research
Baseline prostate health index risk category and risk category changes during active surveillance predict grade reclassification
CONCLUSIONS: Baseline PHI risk category and PHI changes over time were both independent predictors of GR after confirmatory biopsy, but the added benefit over PSAD seemed modest. However, baseline PHI and PHI risk category changes provided clinically useful risk stratification for time to GR, so further evaluation of PHI's ability to help reduce the frequency of mpMRI and/or surveillance biopsies with more PHI data points over time may be warranted.PMID:37722985 | DOI:10.1016/j.urolonc.2023.08.011
Source: Urologic Oncology - September 18, 2023 Category: Urology & Nephrology Authors: Claire M de la Calle Yuezhou Jing Mufaddal M Mamawala Patricia Landis Katarzyna J Macura Bruce J Trock Jonathan I Epstein Lori J Sokoll Christian P Pavlovich Source Type: research
Dosimetric impact of MLC positional errors on dose distribution in IMRT
This study investigates dose sensitivity variations and complexity metrics of MLC positional error in volumetric modulated arc therapy and determines the acceptable ranges of MLC positional accuracy in several clinical situations. Treatment plans were generated for four treatment sites (prostate cancer, lung cancer, spinal, and brain metastases) using different treatment planning systems (TPSs) and fraction sizes. Each treatment plan introduced 0.25-2.0 mm systematic or random MLC leaf bank errors. The generalized equivalent uniform dose (gEUD) sensitivity and complexity metrics (MU/Gy and plan irregularity) were calculate...
Source: Health Physics - September 18, 2023 Category: Physics Authors: Hiromi Enomoto Yukio Fujita Saki Matsumoto Yujiro Nakajima Miyuki Nagai Ayako Tonari Takeshi Ebara Source Type: research
mpMRI-targeted biopsy of the prostate in men ≥ 75 years. 7-year report from a high-volume referral center
CONCLUSION: After evaluation of a large patient cohort, we show that age≥75 years represents a significant risk factor for the detection of clinically significant prostate cancer. Further studies on mid- and long term outcome are necessary to draw conclusions for clinical decision making in this patient cohort.PMID:37718788 | DOI:10.3233/CH-238101
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Michael Chaloupka Nikolaos Pyrgidis Benedikt Ebner Paulo Pfitzinger Yannic Volz Elena Berg Benazir Abrarova Michael Atzler Troya Ivanova Paulo Pfitzinger Christian G Stief Maria Apfelbeck Dirk-Andr é Clevert Source Type: research
Dosimetric impact of MLC positional errors on dose distribution in IMRT
This study investigates dose sensitivity variations and complexity metrics of MLC positional error in volumetric modulated arc therapy and determines the acceptable ranges of MLC positional accuracy in several clinical situations. Treatment plans were generated for four treatment sites (prostate cancer, lung cancer, spinal, and brain metastases) using different treatment planning systems (TPSs) and fraction sizes. Each treatment plan introduced 0.25-2.0 mm systematic or random MLC leaf bank errors. The generalized equivalent uniform dose (gEUD) sensitivity and complexity metrics (MU/Gy and plan irregularity) were calculate...
Source: Journal of Applied Clinical Medical Physics - September 18, 2023 Category: Physics Authors: Hiromi Enomoto Yukio Fujita Saki Matsumoto Yujiro Nakajima Miyuki Nagai Ayako Tonari Takeshi Ebara Source Type: research
Baseline prostate health index risk category and risk category changes during active surveillance predict grade reclassification
CONCLUSIONS: Baseline PHI risk category and PHI changes over time were both independent predictors of GR after confirmatory biopsy, but the added benefit over PSAD seemed modest. However, baseline PHI and PHI risk category changes provided clinically useful risk stratification for time to GR, so further evaluation of PHI's ability to help reduce the frequency of mpMRI and/or surveillance biopsies with more PHI data points over time may be warranted.PMID:37722985 | DOI:10.1016/j.urolonc.2023.08.011
Source: Urologic Oncology - September 18, 2023 Category: Urology & Nephrology Authors: Claire M de la Calle Yuezhou Jing Mufaddal M Mamawala Patricia Landis Katarzyna J Macura Bruce J Trock Jonathan I Epstein Lori J Sokoll Christian P Pavlovich Source Type: research
F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Biochemical and Biophysical Research communications - September 17, 2023 Category: Biochemistry Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research
Reciprocal negative feedback regulation of ATF6 α and PTEN promotes prostate cancer progression
Cell Mol Life Sci. 2023 Sep 16;80(10):292. doi: 10.1007/s00018-023-04940-3.ABSTRACTPhosphatase and tensin homolog (PTEN) loss tightly correlates with prostate cancer (PCa) progression and metastasis. Inactivation of PTEN leads to abnormal activation of PI3K/AKT pathway. However, results from clinical trials with AKT inhibitors in PCa have been largely disappointing. Identification of novel regulators of PTEN in PTEN-dysfunctional PCa is urgently needed. Here we demonstrated that the expression level of PTEN is inversely correlated with the signature score of unfolded protein response (UPR) in PCa. Importantly, PTEN suppres...
Source: Cellular and Molecular Life Sciences : CMLS - September 16, 2023 Category: Cytology Authors: Tingting Feng Ru Zhao Hanwen Zhang Feifei Sun Jing Hu Meng Wang Mei Qi Ling Liu Lin Gao Yabo Xiao Junhui Zhen Weiwen Chen Lin Wang Bo Han Source Type: research
A review of recent advancements in Actinium-225 labeled compounds and biomolecules for therapeutic purposes
Chem Biol Drug Des. 2023 Sep 15. doi: 10.1111/cbdd.14311. Online ahead of print.ABSTRACTIn nuclear medicine, cancers that cannot be cured or can only be treated partially by traditional techniques like surgery or chemotherapy are killed by ionizing radiation as a form of therapeutic treatment. Actinium-225 is an alpha-emitting radionuclide that is highly encouraging as a therapeutic approach and more promising for targeted alpha therapy (TAT). Actinium-225 is the best candidate for tumor cells treatment and has physical characteristics such as high (LET) linear energy transfer (150 keV per μm), half-life (t1/2 = 9.92d), a...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Maria Hassan Tanveer Hussain Bokhari Nadeem Ahmed Lodhi Muhammad Kaleem Khosa Muhammad Usman Source Type: research
