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Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer
CONCLUSION: The AR-interactors might be useful markers for prostate cancer diagnosis and prognosis, and provide a new sight for revealing the molecular mechanism of CRPC progression.PMID:37667572 | DOI:10.22037/uj.v20i.7469
Source: Urology Journal - September 5, 2023 Category: Urology & Nephrology Authors: Zhu Wang Ying Zhang Qiong Deng Jianwen Zhang Xisheng Wang Hui Liang Source Type: research
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3;94:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may ...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer
CONCLUSION: The AR-interactors might be useful markers for prostate cancer diagnosis and prognosis, and provide a new sight for revealing the molecular mechanism of CRPC progression.PMID:37667572 | DOI:10.22037/uj.v20i.7469
Source: Urology Journal - September 5, 2023 Category: Urology & Nephrology Authors: Zhu Wang Ying Zhang Qiong Deng Jianwen Zhang Xisheng Wang Hui Liang Source Type: research
Emerging role of miRNA in prostate cancer: A future era of diagnostic and therapeutics
Gene. 2023 Sep 2:147761. doi: 10.1016/j.gene.2023.147761. Online ahead of print.ABSTRACTProstate cancer (PCa) is the most common cancer in men (20%) and is responsible for 6.8% (1/5) of all cancer-related deaths in men around the world. The development and spread of prostate cancer are driven by a wide variety of genomic changes and extensive epigenetic events. Because of this, the MicroRNA (miRNA) and associated molecular mechanisms involved in PCa genesis and aggressive were only partially identified until today. The miRNAs are a newly discovered category of regulatorsthat have recently been recognized to have a signific...
Source: Gene - September 4, 2023 Category: Genetics & Stem Cells Authors: Mohd Mabood Khan Vineeta Sharma Mohammad Serajuddin Source Type: research
Fractional Modeling of Cancer with Mixed Therapies
CONCLUSIONS: At the end, a curve fitting procedure is presented which may help medical practitioners to treat cancer patients.PMID:37664940 | DOI:10.31083/j.fbl2808174
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Shumaila Javeed Zain Ul Abdeen Dumitru Baleanu Source Type: research
New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & amp; therapeutics
Front Oncol. 2023 Aug 17;13:1193736. doi: 10.3389/fonc.2023.1193736. eCollection 2023.ABSTRACTProstate adenocarcinoma accounts for more than 20% of deaths among males due to cancer. It is the fifth-leading cancer diagnosed in males across the globe. The mortality rate is quite high due to prostate cancer. Despite the fact that advancements in diagnostics and therapeutics have been made, there is a lack of effective drugs. Metabolic pathways are altered due to the triggering of androgen receptor (AR) signaling pathways, and elevated levels of dihydrotestosterone are produced due to defects in AR signaling that accelerate th...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Neha Thakur Sameer Quazi Bindu Naik Saurabh Kumar Jha Pallavi Singh Source Type: research
Epidemiological Patterns of Common Cancers in Costa Rica: An Overview up to 2020
CONCLUSION: The results of this study underscore the need for targeted prevention and screening programs, improved access to treatment for patients living in rural areas, and a comprehensive cancer control program in Costa Rica. By implementing evidence-based interventions, such as tobacco control programs, cancer screening initiatives, and equitable access to cancer treatment, the cancer burden in Costa Rica can be mitigated, ultimately improving the overall health of the population.PMID:37663950 | PMC:PMC10475317 | DOI:10.4236/jss.2023.116033
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Calderon Alejandro Guzman Percy Murphy Jack Source Type: research
Thermal necrosis in orthopedic bone tumors: experimental research
CONCLUSION: This study demonstrated in vitro thresholds for thermal necrosis for cell lines of common orthopedic tumors of bone. The A549 (lung carcinoma), K1 (thyroid carcinoma), and FU-UR-1 (renal carcinoma) cell lines demonstrated greater resistance to heat stress compared to non-neoplastic control cells. Temperatures in excess of 90°C are necessary to reliably reduce cell survival and viability to less than 10%.PMID:37663713 | PMC:PMC10473360 | DOI:10.1097/MS9.0000000000001052
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Xue Qi Wang Jeffrey M Brown Shannon Lorimer Kevin B Jones John S Groundland Source Type: research
Prostate cancer-related sexual dysfunction - the significance of social relations in men's reconstructions of masculinity
Cult Health Sex. 2023 Sep 4:1-15. doi: 10.1080/13691058.2023.2250410. Online ahead of print.ABSTRACTNarrating illness experiences in a culturally acceptable manner is essential for retaining quality of life after the disruptive event of being diagnosed for prostate cancer. Psychological pressures caused by treatment side-effects such as erectile dysfunction require reinterpretation of the meanings and impacts of these side-effects on masculinity. This helps maintain coherence in men's lives. We studied how men employ culturally available discursive strategies (compensation, redefinition, recontextualisation, and normalisat...
Source: Culture, Health and Sexuality - September 4, 2023 Category: International Medicine & Public Health Authors: Anna-Maija Talvitie Hanna Ojala Teuvo Tammela Ilkka Pietil ä Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
