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Is it right to cut corners in the search for a coronavirus cure? | Julian Savulescu
Vaccine and drug trials are slow, to account for safety. But in a pandemic time isn ’t just money – it’s lives• Coronavirus latest updates• See all our coronavirus coverageThe race is on to find a treatment for coronavirus. This race is split between two approaches: the trialling of pre-existing drugs used for similar diseases, and thehunt for a vaccine. In both instances, important ethical decisions must be made. Is it OK to reassign a treatment that comes with side-effects? And with thousands dying from coronavirus every day, is it acceptable to cut corners in the search for a vaccine?Related:Coronavirus vaccin...
Source: Guardian Unlimited Science - March 25, 2020 Category: Science Authors: Julian Savulescu Tags: Coronavirus outbreak Infectious diseases Medical research Science World news Ethics Source Type: news
Ethics and Evidence in the Search for a Vaccine and Treatments for Covid-19
In the rush to find a Covid-19 vaccine and one or more drugs to treat the deadly disease, concerns are being raised that ethical standards for conducting human clinical trials and the evidentiary standards for determining whether interventions are safe and effective, might be loosened.
The post Ethics and Evidence in the Search for a Vaccine and Treatments for Covid-19 appeared first on The Hastings Center.
Source: blog.bioethics.net - April 15, 2020 Category: Medical Ethics Authors: Susan Gilbert Tags: Health Care Public Health Research Ethics clinical trials COVID-19 evidence Hastings Bioethics Forum syndicated Source Type: blogs
In the search of potential epitopes for Wuhan seafood market pneumonia virus using high order nullomers.
Abstract
Alarms periodically emerge for viral pneumonia infections due to coronavirus. In all cases, these are zoonoses passing the barrier between species and infect humans. The legitimate concern of the international community is due to the fact that the new identified coronavirus, named SARS-CoV-2 (previously called 2019-nCoV), has a quite high mortality rate, around 2%, and a strong ability to spread, with an estimated reproduction number higher than 2. Even though all countries are doing their utmost to stop the pandemic, the only reliable solution to tackle the infection is the rapid development of a vaccine...
Source: Journal of Immunological Methods - April 22, 2020 Category: Allergy & Immunology Authors: Santoni D, Vergni D Tags: J Immunol Methods Source Type: research
The search for an HIV vaccine, the journey continues.
Authors: Dieffenbach CW, Fauci AS
PMID: 32418357 [PubMed - in process]
Source: Journal of the International AIDS Society - May 19, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
The search for yellow fever virus vaccine in breast milk of inadvertently vaccinated women in Brazil.
Abstract
Eleven lactating women were inadvertently vaccinated with 17DD yellow fever vaccine in a small city of Sao Paulo State, Brazil. Their infants were being exclusively breast-fed and the breastfeeding was interrupted for 10 days. Serum and breastmilk were collected from the vaccinated mothers and tested for the presence of genomic RNA of the vaccine strain 8, 10 and 15 days after vaccination. Viral RNA was not detected in any of the serum and human milk samples tested and the infants remained asymptomatic. Our result strengthens the effectineness of stopping breastfeeding for 10 days after the inadvertent ye...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - June 4, 2020 Category: Tropical Medicine Authors: Fernandes EG, Nogueira JS, Porto VBG, Sato HK Tags: Rev Inst Med Trop Sao Paulo Source Type: research
COVID-19 mouse model will speed search for drugs, vaccines
(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis have developed a mouse model of COVID-19 that is expected to speed up the search for drugs and vaccines for the potentially deadly disease.
Source: EurekAlert! - Infectious and Emerging Diseases - June 10, 2020 Category: Infectious Diseases Source Type: news
Computational search for potential COVID-19 drugs from FDAapproved drugs and small molecules of natural origin identifies several anti-virals and plant products.
Abstract
The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses which was identified to infect humans first in December 2019. SARS-CoV-2 shares evolutionary relationship to other highly pathogenic viruses such as Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS). We have exploited this sim...
Source: Journal of Biosciences - July 29, 2020 Category: Biomedical Science Authors: Sharma A, Tiwari V, Sowdhamini R Tags: J Biosci Source Type: research
Independent search engines respect your privacy but give more visibility to misinformation
(University of Sussex) Anti-vaccine websites, which could play a key role in promoting public hesitancy about a potential COVID vaccine, are far more likely to be found via independent search engines than through an internet giant like Google.
Source: EurekAlert! - Medicine and Health - August 13, 2020 Category: International Medicine & Public Health Source Type: news
Do fathers care about their own immunisation status? The Child-Parent-Immunisation Survey and a review of the literature.
Abstract
We recently conducted a large survey amongst parents of young children exploring attitudes concerning immunisation and the general immunisation status of the children and their parents in Switzerland. Since little is known about the immunisation status of fathers of young children, we present our findings here; data on mothers were previously published elsewhere. We performed standardised interviews with parents of children born on or after 1 January 2013, and hospitalised at the University of Basel Children’s Hospital, Switzerland, between January and June 2017. If participation was declined, p...
Source: Swiss Medical Weekly - July 26, 2020 Category: General Medicine Authors: Erb ML, Erlanger TE, Heininger U Tags: Swiss Med Wkly Source Type: research
South Africa: UCT Joins Search for Covid-19 Vaccine
[UCT] South Africa has joined global counterparts in search for a COVID-19 vaccine and the University of Cape Town (UCT) is lending a hand, participating in three international trials in the country, alongside several other universities.
Source: AllAfrica News: Health and Medicine - August 26, 2020 Category: African Health Source Type: news
In search of a vaccine against COVID-19: implications for nursing practice.
This article discusses the background to the current COVID-19 pandemic. The specific features of the causative pathogen (SARS-CoV-2) are outlined, together with a 'whistlestop' revision of immunological principles. The article goes on to discuss the principles and mechanisms of immunisation and the stages of vaccine development. The current situation in relation to the race to develop a vaccine against COVID-19 is incorporated and the immunological principles being adapted by the top contenders are outlined. These include new approaches based on genetic sequencing. Finally, the importance of understanding theoretical princ...
Source: British Journal of Nursing - September 9, 2020 Category: Nursing Authors: Boulton J Tags: Br J Nurs Source Type: research
Viruses, Vol. 13, Pages 106: Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug
In this study we present systematic and integrative antiviral drug repurposing effort aimed at identifying, among the drugs already authorized for clinical use, some active inhibitors of the SARS-CoV-2 main protease. The most important result of this analysis is the demonstration that ethacrynic acid, a powerful diuretic, is revealed to be an effective inhibitor of SARS-CoV-2 main protease. Even with all the necessary cautions, given the particular nature of this drug, these data can be the starting point for the development of an effective therapeutic strategy against SARS-CoV-2.
Source: Viruses - January 13, 2021 Category: Virology Authors: Camilla Isgr ò Anna Maria Sardanelli Luigi Leonardo Palese Tags: Article Source Type: research
Ebolavirus: Comparison of Survivor Immunology and Animal Models in the Search for a Correlate of Protection
Ebola viruses are enveloped, single-stranded RNA viruses belonging to the Filoviridae family and can cause Ebola virus disease (EVD), a serious haemorrhagic illness with up to 90% mortality. The disease was first detected in Zaire (currently the Democratic Republic of Congo) in 1976. Since its discovery, Ebola virus has caused sporadic outbreaks in Africa and was responsible for the largest 2013–2016 EVD epidemic in West Africa, which resulted in more than 28,600 cases and over 11,300 deaths. This epidemic strengthened international scientific efforts to contain the virus and develop therapeutics and vaccines. Immunology...
Source: Frontiers in Immunology - February 19, 2021 Category: Allergy & Immunology Source Type: research
Rwanda: Rwanda Optimistic About Latest Breakthrough in Search for a Malaria Vaccine
[New Times] Officials at Rwanda Biomedical Centre (RBC) have said they are optimistic about the recent unprecedented developments in the search for a malaria vaccine, and hope soon there will be a vaccine to complement the existing measures to fight the disease.
Source: AllAfrica News: Malaria - April 26, 2021 Category: Infectious Diseases Source Type: news
New Research Provides Hope In The Search For A Respiratory Syncytial Virus Vaccine- Part II
Respiratory syncytial virus is one of the leading causes of death for infants globally, and a safe vaccine has yet to be approved for use. However, the long search may soon be over, as new structure-based vaccine technology holds great promise.
Source: Forbes.com Healthcare News - May 3, 2022 Category: Pharmaceuticals Authors: William A. Haseltine, Contributor Tags: Healthcare /healthcare Innovation /innovation business pharma & Source Type: news
