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Vaccination: Vaccines

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New Research Provides Hope In The Search For A Respiratory Syncytial Virus Vaccine- Part III
While the search for a vaccine for respiratory syncytial virus has eluded scientists and vaccine manufacturers for decades, it looks as if there may be a vaccine in the foreseeable future, within the next few years.
Source: Forbes.com Healthcare News - May 10, 2022 Category: Pharmaceuticals Authors: William A. Haseltine, Contributor Tags: Healthcare /healthcare Innovation /innovation Coronavirus business pharma & Source Type: news

Cancers, Vol. 14, Pages 4191: Cancerous Tumor Controlled Treatment Using Search Heuristic (GA)-Based Sliding Mode and Synergetic Controller
ad Fazal Ijaz Cancerous tumor cells divide uncontrollably, which results in either tumor or harm to the immune system of the body. Due to the destructive effects of chemotherapy, optimal medications are needed. Therefore, possible treatment methods should be controlled to maintain the constant/continuous dose for affecting the spreading of cancerous tumor cells. Rapid growth of cells is classified into primary and secondary types. In giving a proper response, the immune system plays an important role. This is considered a natural process while fighting against tumors. In recent days, achieving a better method to treat ...
Source: Cancers - August 29, 2022 Category: Cancer & Oncology Authors: Fazal Subhan Muhammad Adnan Aziz Inam Ullah Khan Muhammad Fayaz Marcin Wozniak Jana Shafi Muhammad Fazal Ijaz Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7336: Homology Modeling and Molecular Dynamics-Driven Search for Natural Inhibitors That Universally Target Receptor-Binding Domain of Spike Glycoprotein in SARS-CoV-2 Variants
Julia Saloni The rapid spread of SARS-CoV-2 required immediate actions to control the transmission of the virus and minimize its impact on humanity. An extensive mutation rate of this viral genome contributes to the virus’ ability to quickly adapt to environmental changes, impacts transmissibility and antigenicity, and may facilitate immune escape. Therefore, it is of great interest for researchers working in vaccine development and drug design to consider the impact of mutations on virus-drug interactions. Here, we propose a multitarget drug discovery pipeline for identifying potential drug candidates w...
Source: Molecules - October 28, 2022 Category: Chemistry Authors: Olha Ovchynnykova Karina Kapusta Natalia Sizochenko Kostyantyn M. Sukhyy Wojciech Kolodziejczyk Glake A. Hill Julia Saloni Tags: Article Source Type: research

Effectiveness of the pneumococcal polysaccharide and conjugated vaccines in elderly and high-risk populations in preventing invasive pneumococcal disease: A systematic search and review of the literature
Conclusion: The results from this review indicate a reduction of IPD in elderly and high-risk populations vaccinated with PPV23 and PCV13. The protective effect may be lower in elderly individuals >80 years and in individuals with comorbidities. However, the literature is sparse and large-scale prospective studies are needed to evaluate the effectiveness of PPV23 and PCV13 vaccination in adults in protecting against IPD.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Sikjaer, M., Wik, M. S., Stensholt, S. S., Hilberg, O., Lokke, A. Tags: 10.01 - Respiratory infections and bronchiectasis Source Type: research

Viruses, Vol. 15, Pages 1065: Intra-Host Co-Existing Strains of SARS-CoV-2 Reference Genome Uncovered by Exhaustive Computational Search
In this study, we present a computational method aimed at identifying co-existing intra-host strains of the virus from RNA-sequencing data of short reads that were used to assemble the original reference genome. Our method consisted of five key steps: extraction of relevant reads, error correction for the reads, identification of within-host diversity, phylogenetic study, and protein binding affinity analysis. Our study revealed that multiple strains of SARS-CoV-2 can coexist in both the viral sample used to produce the reference sequence and a wastewater sample from California. Additionally, our workflow demonstrated its ...
Source: Viruses - April 26, 2023 Category: Virology Authors: Xinhui Cai Tian Lan Pengyao Ping Brian Oliver Jinyan Li Tags: Article Source Type: research

The CXCR5 T follicular helper cell compartment in children with antibody deficiencies-in search of a prognostic marker of childhood hypogammaglobulinemia
CONCLUSIONS: A deficiency of Tfh cells in young infants mirrors the immaturity of the humoral immune response, whereas in older children Tfh cells are proposed as a prognostic marker facilitating to distinguish between mild hypogammaglobulinemia and the developing common variable immunodeficiency.PMID:33641302 | DOI:10.15586/aei.v49i2.34
Source: Allergologia et Immunopathologia - February 28, 2021 Category: Allergy & Immunology Authors: Aleksandra Szczawinska-Poplonyk Katarzyna Tapolska-Jozwiak Husam Samara Maciej Boruczkowski Barbara Wieckowska Source Type: research