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Cancer: Squamous Cell Carcinoma
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Total 19037 results found since Jan 2013.
miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas
CONCLUSIONS: In summary, RDEB-SCCs exist in different EMT states and the level of miR-200b is indicative of how far an RDEB-SCC has gone down the EMT path. Moreover, reintroduction of miR-200b significantly reduced mesenchymal features.PMID:37681509 | DOI:10.1093/bjd/ljad335
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Julia Illmer Roland Zauner Josefina Pi ñón Hofbauer Monika Wimmer Stefanie Gruner Michael Ablinger Johannes Bischof Sonja Dorfer Stefan Hainzl Vanessa Tober Shir Bergson Ofer Sarig Liat Samuelov Christina Guttmann-Gruber Ruby Shalom-Feuerstein Eli Sprec Source Type: research
Clinical Relevance of Patient-Derived Organoid of Surgically Resected Lung Cancer as an In Vitro Model for Biomarker and Drug Testing
CONCLUSIONS: The establishment and growth rates of LTOs were associated with the histologic subtype and tumor size. LTOs derived from resected specimens have become preclinical models that can be used to predict drug responses and accelerate the development of treatment strategies for patients with rare mutations.PMID:37681218 | PMC:PMC10480534 | DOI:10.1016/j.jtocrr.2023.100554
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Takamasa Koga Junichi Soh Akira Hamada Yuki Miyano Toshio Fujino Keiko Obata Shuta Ohara Masaya Nishino Masato Chiba Masaki Shimoji Toshiki Takemoto Kenichi Suda Kazuko Sakai Hidenori Sato Tetsuya Mitsudomi Source Type: research
Importance of tumor volume, overall treatment time and fractionation sensitivity for p16-positive and p16-negative oropharyngeal tumors
CONCLUSION: Primary tumor volume plays a crucial role in predicting local tumor response, particularly in p16-positive OPSCC. The estimated α/β-ratio for p16-positive oropharyngeal tumors aligns with previous HNSCC studies, whereas the impact of prolonged OTT was slightly less than previously reported. The differences in radiosensitivity depending on p16-status were quantified. The findings should be validated in independent cohorts.PMID:37682690 | DOI:10.1080/0284186X.2023.2251084
Source: Acta Oncologica - September 8, 2023 Category: Cancer & Oncology Authors: Gabriel Adrian Maria Gebre-Medhin Per Nilsson Source Type: research
Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease
CONCLUSION: CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.PMID:37680128 | DOI:10.2174/1381612829666230901143203
Source: Current Pharmaceutical Design - September 8, 2023 Category: Drugs & Pharmacology Authors: Fengyu Zhang Meidi Zhang Xin Yuan Yulian Tao Ju Wang Source Type: research
miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas
CONCLUSIONS: In summary, RDEB-SCCs exist in different EMT states and the level of miR-200b is indicative of how far an RDEB-SCC has gone down the EMT path. Moreover, reintroduction of miR-200b significantly reduced mesenchymal features.PMID:37681509 | DOI:10.1093/bjd/ljad335
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Julia Illmer Roland Zauner Josefina Pi ñón Hofbauer Monika Wimmer Stefanie Gruner Michael Ablinger Johannes Bischof Sonja Dorfer Stefan Hainzl Vanessa Tober Shir Bergson Ofer Sarig Liat Samuelov Christina Guttmann-Gruber Ruby Shalom-Feuerstein Eli Sprec Source Type: research
Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease
CONCLUSION: CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.PMID:37680128 | DOI:10.2174/1381612829666230901143203
Source: Current Pharmaceutical Design - September 8, 2023 Category: Drugs & Pharmacology Authors: Fengyu Zhang Meidi Zhang Xin Yuan Yulian Tao Ju Wang Source Type: research
The level of macrophage migration inhibitory factor is negatively correlated with the efficacy of PD-1 blockade immunotherapy combined with chemotherapy as a neoadjuvant therapy for esophageal squamous cell carcinoma
CONCLUSION: Baseline MIF levels were negatively correlated with neoadjuvant therapy efficacy. Thus, MIF may serve as a predictive biomarker for this therapy. The accuracy of the prediction could be improved if the serum concentration of MIF is measured again after the patient received several weeks of treatment.PMID:37678132 | DOI:10.1016/j.tranon.2023.101775
Source: Translational Oncology - September 7, 2023 Category: Cancer & Oncology Authors: Liangliang Wu Yiming Gao Shengzhi Xie Wan Ye Yasushi Uemura Rong Zhang Yanju Yu Jinfeng Li Man Chen Qiyan Wu Pengfei Cui Hongyu Liu Shuai Mu Yilan Li Lingxiong Wang Chunxi Liu Jiahui Li Lijun Zhang Shunchang Jiao Guoqing Zhang Tianyi Liu Source Type: research
Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross-sectional, case-control study
CONCLUSION: Our study provides valuable insights into the epidemiology and prognosis of PE in lung cancer patients and suggests that a poor ECOG PS, which has not been previously reported, is an independent risk factor for PE.PMID:37675831 | DOI:10.1111/crj.13692
Source: Respiratory Care - September 7, 2023 Category: Respiratory Medicine Authors: Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian-An Huang Yixin Lian Source Type: research
"Squamous cell carcinoma developed in a trichilemmal cyst, an incidental finding"
Actas Dermosifiliogr. 2023 Sep 5:S0001-7310(23)00690-7. doi: 10.1016/j.ad.2023.05.032. Online ahead of print.NO ABSTRACTPMID:37678632 | DOI:10.1016/j.ad.2023.05.032
Source: Actas Dermo-Sifiliograficas - September 7, 2023 Category: Dermatology Authors: J P érez Wilson G Coulon C Whittle A Castro Source Type: research
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023225. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription factor in ESCC. The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is signific...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aiping Xu Mingchuang Sun Zhaoxing Li Yuan Chu Kang Fang Yunwei Zhang Jingjing Lian Li Zhang Tao Chen Meidong Xu Source Type: research
Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross-sectional, case-control study
CONCLUSION: Our study provides valuable insights into the epidemiology and prognosis of PE in lung cancer patients and suggests that a poor ECOG PS, which has not been previously reported, is an independent risk factor for PE.PMID:37675831 | DOI:10.1111/crj.13692
Source: Respiratory Care - September 7, 2023 Category: Respiratory Medicine Authors: Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian-An Huang Yixin Lian Source Type: research
Crosstalk between PD-L1 and Jak2-Stat3/ MAPK-AP1 signaling promotes oral cancer progression, invasion and therapy resistance
CONCLUSIONS: PD-L1 was regulated mainly by the Jak2-Stat3/ MAPK-AP1 pathway, and besides the routine immunological functions, it supports OSCC survival, invasion, and therapy resistance. PD-L1 can be used as an indicator of severity and can be targeted along with Jak2-Stat3/ MAPK-AP1 for a better outcome OSCC.PMID:37678027 | DOI:10.1016/j.intimp.2023.110894
Source: International Immunopharmacology - September 7, 2023 Category: Allergy & Immunology Authors: Arpita Jha Manzar Alam Tanushree Kashyap Nidhi Nath Anjali Kumari Kamdeo K Pramanik Siddavaram Nagini Rajakishore Mishra Source Type: research
Encephalitis in a patient with hypopharynx cancer treated with immune checkpoint inhibitors and radiotherapy: a case report and review of the literature
J Cancer Res Clin Oncol. 2023 Sep 7. doi: 10.1007/s00432-023-05328-3. Online ahead of print.ABSTRACTHypopharyngeal cancer (HPC) has one of the most unfavorable prognoses among head and neck squamous cell carcinomas. Immunotherapy in combination with chemotherapy, the same as conventional induction chemotherapy, has emerged as a vital part of the induction therapy protocol for HPC. Meanwhile, the incidence of immune-related adverse events is increasing. In this light, we present the first reported case of immune-associated encephalitis in a patient with hypopharyngeal cancer treated with Camrelizumab (a PD-1 inhibitor). Aft...
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Yan Kang Hongchao Zhen Nina Ma Hong Zhao Bangwei Cao Source Type: research
