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Cancer: Squamous Cell Carcinoma
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Total 19037 results found since Jan 2013.
Genomic and Transcriptomic Landscape of an Oral Squamous Cell Carcinoma Mouse Model for Immunotherapy
Cancer Immunol Res. 2023 Sep 5. doi: 10.1158/2326-6066.CIR-23-0133. Online ahead of print.ABSTRACTThe immune checkpoint inhibitor (ICI), anti-programmed death-1 (anti-PD-1), has shown moderate efficacy in some patients with head and neck squamous cell carcinoma (HNSCC). Because of this, it is imperative to establish a mouse tumor model to explore mechanisms of antitumor immunity and to develop novel therapeutic options. Here, we examined the 4-nitroquinoline-1-oxide (4NQO)-induced oral squamous cell carcinoma (OSCC) model for genetic aberrations, transcriptomic profiles, and immune cell composition at different pathologica...
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Yi-Mei Lee Chia-Lang Hsu Yu-Hsin Chen Da-Liang Ou Chiun Hsu Ching-Ting Tan Source Type: research
Precise pattern of lymphatic spread of esophageal squamous cell carcinoma: results of 1074 patients with N1 disease
CONCLUSION: Bilateral recurrent nerve nodes, paraesophageal lymph nodes, and perigastric nodes were the most common sites of early lymph node metastasis. Esophageal squamous cell carcinoma involves more longitudinal than transverse lymph node metastases.PMID:37668800 | DOI:10.1007/s00432-023-05359-w
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Kailin Lin Bin Li Yihua Sun Hong Hu Yawei Zhang Jiaqing Xiang Haiquan Chen Source Type: research
A case of squamous cell carcinoma in situ of the cornea of the left eye
Asian J Surg. 2023 Sep 1:S1015-9584(23)01351-9. doi: 10.1016/j.asjsur.2023.08.192. Online ahead of print.NO ABSTRACTPMID:37661481 | DOI:10.1016/j.asjsur.2023.08.192
Source: Asian Journal of Surgery - September 4, 2023 Category: Surgery Authors: Shuang Rao Source Type: research
Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma
Oral Oncol. 2023 Sep 2;146:106562. doi: 10.1016/j.oraloncology.2023.106562. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCC) are associated with significant treatment-related morbidity and poor disease-free and disease-specific survival, especially in the recurrent and metastatic (R/M HNSCC) setting. Inhibition of the programmed death-1/ligand-1 (PD-1/PD-L1) immune checkpoint is accepted as a first-line treatment strategy for R/M HNSCC and has expanded into the neoadjuvant, definitive, and adjuvant settings. To understand cellular signals modulating the PD-L1 in HNSCC, we profiled a HNSCC cell-l...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Jacqueline E Mann Joshua D Smith Aditi Kulkarni Susan K Foltin Erin B Scheftz Isabel R Murray Elizabeth Gensterblum-Miller Collin V Brummel Apurva Bhangale Rebecca C Hoesli J Chad Brenner Source Type: research
Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma
Target Oncol. 2023 Sep 4. doi: 10.1007/s11523-023-00993-3. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCCs) are often associated with poor outcomes, due at least in part to the limited number of treatment options available for those patients who develop recurrent and/or metastatic disease (R/M HNSCC). Even with the recent validation and approval of immunotherapies in the first-line setting for these patients, the need for the development of new and alternative precision medicine strategies with survival benefit is clear. Oncogenic alterations in the HRAS (Harvey rat sarcoma virus) proto-oncogen...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Jiayu Wang Dana Al-Majid J Chad Brenner Joshua D Smith Source Type: research
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells
CONCLUSION: PARN has antiapoptotic effects on EC cells and promotes their proliferation, invasion and migration, which is associated with the development of EC and poor patient prognosis. PARN may become a potential target for the diagnosis, prognosis prediction and treatment of EC.PMID:37664151 | PMC:PMC10473923 | DOI:10.3748/wjg.v29.i31.4783
Source: World Journal of Gastroenterology - September 4, 2023 Category: Gastroenterology Authors: Fu-Wei Zhang Xiao-Wei Xie Meng-Hua Chen Jian Tong Qun-Qing Chen Jing Feng Feng-Ti Chen Wen-Qi Liu Source Type: research
Identification and validation of a prognostic signature of cuproptosis-related genes for esophageal squamous cell carcinoma
In this study, we observed significant expression differences in most of the 12 cuproptosis-related genes (CRGs) in the TCGA-ESCC dataset, which was validated using GSE20347, GSE38129, and individual ESCC datasets. We were able to divide patients in the TCGA-ESCC cohort into two subgroups based on disease, and found significant differences in survivor outcomes and biological functions between these subgroups. Additionally, we identified 11 prognosis-related genes from the 12 CRGs using LASSO COX regression analysis and constructed a CRGs signature for ESCC. Patients were categorized into high- and low-risk subgroups based ...
Source: Aging - September 4, 2023 Category: Biomedical Science Authors: Yiping Zhang Kebing Chen Liyan Wang Juhui Chen Zhizhong Lin Yuanmei Chen Junqiang Chen Yu Lin Yuanji Xu Haiyan Peng Source Type: research
Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma
Target Oncol. 2023 Sep 4. doi: 10.1007/s11523-023-00993-3. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCCs) are often associated with poor outcomes, due at least in part to the limited number of treatment options available for those patients who develop recurrent and/or metastatic disease (R/M HNSCC). Even with the recent validation and approval of immunotherapies in the first-line setting for these patients, the need for the development of new and alternative precision medicine strategies with survival benefit is clear. Oncogenic alterations in the HRAS (Harvey rat sarcoma virus) proto-oncogen...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Jiayu Wang Dana Al-Majid J Chad Brenner Joshua D Smith Source Type: research
DNA methylation of KIFC1 gene in determination of histological diagnosis, prognosis and metastasis of lung cancer
CONCLUSION: In conclusion, the increase in the expression level of the KIFC1 gene is higher in patients diagnosed with LC than in the healthy population, and therefore, the increase in the expression level of the KIFC1 gene due to hypomethylation can be used as a screening biomarker in LC. It can also be considered that the methylation profile of the KIFC1 gene may be a potential biomarker for determining the subtype of squamous cell carcinoma in LC. The results of the study need to be analyzed and continued with a larger number of patients.PMID:37666088 | DOI:10.1016/j.prp.2023.154742
Source: Cell Research - September 4, 2023 Category: Cytology Authors: Betul Celik Ozge Pasin Sena Sen Seref Bugra Tuncer Zubeyde Yaln ız Kayım Seda K ılıc Erciyas Ozge Sukruoglu Erdogan Busra Kurt Gultaslar Arash Adamnejad Ghafour Hulya Yaz ıcı Necat Vakur Olgac Source Type: research
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells
CONCLUSION: PARN has antiapoptotic effects on EC cells and promotes their proliferation, invasion and migration, which is associated with the development of EC and poor patient prognosis. PARN may become a potential target for the diagnosis, prognosis prediction and treatment of EC.PMID:37664151 | PMC:PMC10473923 | DOI:10.3748/wjg.v29.i31.4783
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Fu-Wei Zhang Xiao-Wei Xie Meng-Hua Chen Jian Tong Qun-Qing Chen Jing Feng Feng-Ti Chen Wen-Qi Liu Source Type: research
Personalised decision making to predict absolute metastatic risk in cutaneous squamous cell carcinoma: development and validation of a clinico-pathological model
EClinicalMedicine. 2023 Aug 19;63:102150. doi: 10.1016/j.eclinm.2023.102150. eCollection 2023 Sep.ABSTRACTBACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, affecting more than 2 million people worldwide yearly and metastasising in 2-5% of patients. However, current clinical staging systems do not provide estimates of absolute metastatic risk, hence missing the opportunity for more personalised treatment advice. We aimed to develop a clinico-pathological model that predicts the probability of metastasis in patients with cSCC.METHODS: Nationwide cohorts from (1) all patients with a first primary c...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Barbara Rentroia-Pacheco Selin Tokez Edo M Bramer Zoe C Venables Harmen J G van de Werken Domenico Bellomo David van Klaveren Antien L Mooyaart Loes M Hollestein Marlies Wakkee Source Type: research
Intralesional 5-fluorouracil as a management for cutaneous squamous cell carcinomas: A rural Australian retrospective case series
Australas J Dermatol. 2023 Sep 4. doi: 10.1111/ajd.14148. Online ahead of print.ABSTRACTWhile the gold standard treatment for cutaneous squamous cell carcinomas (cSCCs) is surgical removal, there is a risk of infection, cosmetic and functional deficits. Intralesional 5-fluorouracil (5-FU) has been shown to be a potential non-surgical treatment modality for cSCCs in the literature. The aim was to investigate the safety and feasibility of using intralesional 5-FU to treat cSCCs. A literature review was conducted and a retrospective case series analysed patients who commenced intralesional 5-FU treatment for at least one cSCC...
Source: The Australasian Journal of Dermatology - September 4, 2023 Category: Dermatology Authors: William Luu Michelle Yvonne McRae Source Type: research
Tumour budding in cutaneous squamous cell carcinoma: A novel prognosis risk factor
CONCLUSION: An association was found between tumour budding and most known risk factors in cSCC. We found findings that indicate that the presence of tumour budding is associated with a worse prognosis in terms of LNM, OS and DSS. This supports the results of previous work which has suggested that budding could be related to high-risk cSCC.PMID:37665122 | DOI:10.1111/ajd.14150
Source: The Australasian Journal of Dermatology - September 4, 2023 Category: Dermatology Authors: Loreto Heredia Pablo Vargas-Mora Catalina Jahr Jos é Herranz Pedro Ferrer-Rosende Source Type: research
