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Total 210 results found since Jan 2013.

Acute otitis media and antibiotics - a systematic review.
CONCLUSIONS: ABX appears to have a limited effect on both primary and secondary outcomes compared with placebo. A substantial number of patients experienced AE. New RCTs are needed to further clarify the effect. Ideally, RCTs could be conducted in Danish general practices in collaboration with practicing ear, nose and throat specialists to obtain large unselected populations with high rates of vaccine coverage. Until more evidence is provided, ABX should be considered among children younger than two years of age with severe symptoms of AOM, i.e. fewer and affected well-being. PMID: 33215607 [PubMed - in process]
Source: Danish Medical Journal - November 21, 2020 Category: General Medicine Tags: Dan Med J Source Type: research

Safety and Efficacy of Simultaneous Inoculations of Pneumococcal and Influenza Vaccines in Patients with Coronary Artery Disease.
CONCLUSION: Simultaneous inoculations of TIV and PPSV23 were safety in patients with CAD, suggesting that dual vaccinations can be considered even in patients with CAD. PMID: 33055462 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - October 21, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Can celiac disease affect life expectancy?
Celiac disease (CD), triggered by the ingestion of gluten, occurs in people genetically predisposed to develop the chronic autoimmune condition. During the past few decades, doctors have learned much about how the disease develops, including genetic and other risk factors. However, results from studies on whether people with CD have an increased risk of premature death linked to the condition have been mixed. A recent study shows a small but statistically significant increased mortality rate. Celiac disease can affect the entire body Until recently, CD was considered a mainly pediatric gastrointestinal disorder, associated...
Source: Harvard Health Blog - May 28, 2020 Category: Consumer Health News Authors: Maureen Leonard, MD, MMSc Tags: Allergies Autoimmune diseases Source Type: blogs

Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Some unconventional thoughts on coronavirus (COVID-19)
Public health authorities are advising frequent hand washing and social distancing, especially in the absence of confirmatory testing for COVID-19. I don’t have any wisdom to add to these practices. Vaccines are in the works, as are anti-viral drugs—nothing to add here, either. But let me reiterate what we do in the Wheat Belly and Undoctored lifestyles. In general, we do not treat diseases; we correct the factors that allow disease to emerge in the first place—a big difference. Take rheumatoid arthritis, for example. In conventional healthcare, the joint pain and swelling of rheumatoid arthritis are sup...
Source: Wheat Belly Blog - March 18, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open probiotic undoctored wheat belly Source Type: blogs

Otitis Media: Rapid Evidence Review.
Abstract Acute otitis media (AOM) is the most common diagnosis in childhood acute sick visits. By three years of age, 50% to 85% of children will have at least one episode of AOM. Symptoms may include ear pain (rubbing, tugging, or holding the ear may be a sign of pain), fever, irritability, otorrhea, anorexia, and sometimes vomiting or lethargy. AOM is diagnosed in symptomatic children with moderate to severe bulging of the tympanic membrane or new-onset otorrhea not caused by acute otitis externa, and in children with mild bulging and either recent-onset ear pain (less than 48 hours) or intense erythema of the t...
Source: American Family Physician - September 14, 2019 Category: Primary Care Authors: Gaddey HL, Wright MT, Nelson TN Tags: Am Fam Physician Source Type: research

Pneumococcal conjugate vaccines for preventing acute otitis media in children.
CONCLUSIONS: Administration of the licenced CRM197-PCV7 and PHiD-CV10 during early infancy is associated with large relative risk reductions in pneumococcal AOM. However, the effects of these vaccines on all-cause AOM is far more uncertain. We found no evidence of a beneficial effect on all-cause AOM of administering PCVs in high-risk infants, after early infancy (i.e. in children one year and above), and in older children with a history of respiratory illness. Compared to control vaccines, PCVs were associated with an increase in mild local reactions (redness, swelling), fever, and pain and/or tenderness. We found no evid...
Source: Cochrane Database of Systematic Reviews - May 27, 2019 Category: General Medicine Authors: Fortanier AC, Venekamp RP, Boonacker CW, Hak E, Schilder AG, Sanders EA, Damoiseaux RA Tags: Cochrane Database Syst Rev Source Type: research

Health-related quality of life of adolescents with sickle cell disease in sub-Saharan Africa: a cross-sectional study
ConclusionsThis study highlighted that pain was negatively associated with both physical and psychosocial functioning; whereas getting Pneumococcal vaccine was positively associated with both physical and psychosocial functioning as reported by children and caretakers.
Source: BMC Hematology - May 13, 2019 Category: Hematology Source Type: research

Life-threating complication of parapharyngeal abscess and mediastinitis in a 10-year-old otherwise healthy girl following elective tonsillectomy - first reported paediatric case.
CONCLUSION: Diagnosing parapharyngeal abscess and mediastinitis can be challenging, but should be suspected and ruled out in cases of post-operative odynophagia, fever, and/or neck swelling and thoracic pain. Diagnosis is made based on magnetic resonance imaging and computed tomography findings. Prompt broad-spectrum intravenous antibiotic treatment and surgical drainage should be initiated. Other severe complications such as meningitis should also be considered. PMID: 30898186 [PubMed - in process]
Source: Journal of Laryngology and Otology - March 24, 2019 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Viruses, Vol. 11, Pages 103: Current In Vitro Models to Study Varicella Zoster Virus Latency and Reactivation
orbolla Varicella zoster virus (VZV) is a highly prevalent human pathogen that causes varicella (chicken pox) during primary infection and establishes latency in peripheral neurons. Symptomatic reactivation often presents as zoster (shingles), but it has also been linked to life-threatening diseases such as encephalitis, vasculopathy and meningitis. Zoster may be followed by postherpetic neuralgia, neuropathic pain lasting after resolution of the rash. The mechanisms of varicella zoster virus (VZV) latency and reactivation are not well characterized. This is in part due to the human-specific nature of VZV that preclude...
Source: Viruses - January 26, 2019 Category: Virology Authors: Nicholas L. Baird Shuyong Zhu Catherine M. Pearce Abel Viejo-Borbolla Tags: Review Source Type: research

The Streptococcos suis sortases SrtB and SrtF are essential for disease in pigs.
In this study, markerless in-frame deletion mutants of the housekeeping sortase srtA and the two pilus-associated sortases, srtB and srtF, were generated and their importance in S. suis infections was investigated. We found that all three of these sortases are essential to disease in pigs, concluding that their cognate-sorted proteins may also be useful in protecting pigs against infection. PMID: 30543506 [PubMed - as supplied by publisher]
Source: Microbiology - December 13, 2018 Category: Microbiology Authors: Faulds-Pain A, Shaw HA, Terra VS, Kellner S, Brockmeier SL, Wren BW Tags: Microbiology Source Type: research

Evidence Based Recommendations for Supportive Care in Multiple Myeloma
Conclusion:Along with anti-myeloma chemotherapy therapy, management of complications (anemia, infections, renal insufficiency) and other associated symptoms is necessary to improve the quality of life.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Qureshi, A., Tariq, M. J., Shah, Z., Abu Zar, M., Aslam, S., Rafae, A., Malik, M. N., Kamal, A., Jose, J. A., Selene, I. I., Shafqat, M., Jamil, F., Durer, S., Durer, C., Anwer, F. Tags: 653. Myeloma: Therapy, excluding Transplantation: Poster I Source Type: research

Conference on Drug Pricing Inject New Statistics Into Debate, Few New Insights (Part 2 of 2)
The first part of this article described the upward pressures on costs and some of the philosophical debates over remedies. This section continues the discussion with several different angles on costs. Universal access and innovation It’s easy to call health care a human right. But consider an analogy: housing could also be considered a human right, yet no one has the right to a twenty-room mansion. Modern drug and genetic research are creating the equivalents of many twenty-room mansions, and taking up residence means the difference between life and death for someone, or perhaps between a long productive life and on...
Source: EMR and HIPAA - November 9, 2018 Category: Information Technology Authors: Andy Oram Tags: Healthcare Reform Medical Economics Personalized Medicine Precision Medicine Drug Pricing Healthcare Costs Medication Pricing Source Type: blogs

Adverse reactions associated with meningococcal group B vaccine (4CMenB) in adults in special situations.
CONCLUSIONS: 4CMenB® shows a good safety profile in adults in special situations. The frequency of fever > 38 ºC is higher than expected. Local  pain is the most frequently recorded adverse reactions, but the intensity is low.  These results suggest a review of the situation in order to suggest a possible  modification of the summary of product characteristics of the vaccine. PMID: 30173636 [PubMed - in process]
Source: Farmacia Hospitalaria - September 1, 2018 Category: Drugs & Pharmacology Authors: Fernández-Prada M, Martínez-Ortega C, Hidalgo-Peña L, Álvarez-Vázquez C, Aguirre-Del Pino R, Huerta-González I Tags: Farm Hosp Source Type: research