Correction to: Rapid and reliable detection of α-globin copy number variations by quantitative real-time PCR
The copy number of the HBA1 assay for the -( α)20.5 deletion in the HBA-CNV method described in the original article [1] was incorrectly reported. (Source: BMC Hematology)
Source: BMC Hematology - October 31, 2019 Category: Hematology Source Type: research

Correction to: Patterns of bone marrow aspiration confirmed hematological malignancies in Eritrean National Health Laboratory
The original version of this article [1] unfortunately included an error to an author ’s name. Author Amin Ata Alamin was incorrectly presented as Anim Ata Alamin.The correct author name has been included in the author list of this Correction article and is already updated in the original article. (Source: BMC Hematology)
Source: BMC Hematology - May 31, 2019 Category: Hematology Source Type: research

Correction to: The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura
In the original version of this article [1], published on 20 September 2018, there was an error in the author name of Dr. Sankari Tarabishi. (Source: BMC Hematology)
Source: BMC Hematology - May 30, 2019 Category: Hematology Source Type: research

Assessment of knowledge, attitude and practice and associated factors of blood donation among health care workers in Ethiopia: a cross-sectional study
AbstractBackgroundBlood can only be given from generous donors. The main objective of this study was to assess the knowledge, attitude and practice (KAP) and associated factors of blood donation among health care workers in Wolaita Sodo University Teaching and Referral Hospital (WSUTRH), Wolaita Sodo, Ethiopia.MethodsAn institution-based cross-sectional study was conducted among 218 WSUTRH health care workers. Socio-demographic characteristics and data related to the levels of KAP of participants were collected using a self-administered questionnaire. Bivariate and multivariate logistic regression analyses were conducted u...
Source: BMC Hematology - May 15, 2019 Category: Hematology Source Type: research

Health-related quality of life of adolescents with sickle cell disease in sub-Saharan Africa: a cross-sectional study
This study aimed to evaluate the health related quality of life (HRoL) of adolescents with SCD.MethodsThis was a mixed-methods study of adolescents with sickle cell disease and their caretakers living in Kampala city, Uganda. All children aged 8 –17 years with homozygous sickle cell disease attending the sickle cell clinic at Mulago Hospital during the study period were included in this study. Participants completed the PedsQL™ generic core scales parent-proxy and child self-report questionnaire during a routine clinic visit. HRQoL wa s the primary outcome measured. Socio-demographics and disease related...
Source: BMC Hematology - May 14, 2019 Category: Hematology Source Type: research

Response to Imatinib therapy is inferior for e13a2 BCR-ABL1 transcript type in comparison to e14a2 transcript type in chronic myeloid leukaemia
ConclusionPatients with an e13a2 transcript demonstrate an inferior molecular response to imatinib in our regional population. (Source: BMC Hematology)
Source: BMC Hematology - May 2, 2019 Category: Hematology Source Type: research

Patterns of bone marrow aspiration confirmed hematological malignancies in Eritrean National Health Laboratory
ConclusionThis study shows that hematologic malignancies are not uncommon in Eritrea. (Source: BMC Hematology)
Source: BMC Hematology - May 2, 2019 Category: Hematology Source Type: research

Anemia and its associated factors among school-age children living in different climatic zones of Arba Minch Zuria District, Southern Ethiopia
AbstractBackgroundAnemia, defined as a low blood hemoglobin concentration, has been shown to be a major public health concern in low-income countries like Ethiopia. School-age children are the most vulnerable population groups for anemia. The aim of this study was to assess the prevalence of anemia, with consideration of altitudinal variations, and to identify factors associated with anemia among school-age children.MethodsA community-based cross-sectional study was conducted from April to May 2017 among randomly selected 391 school-age children (6 to 14  years) in Arba Minch Health and Demographic Surveillance Site...
Source: BMC Hematology - April 23, 2019 Category: Hematology Source Type: research

Seroprevalence of transfusion transmitted infections among blood donors in Gash Barka Zonal Blood Transfusion Center, Barentu, Eritrea, 2014 through 2017
AbstractBackgroundTransfusion-transmissible infections pose a major health risk in developing countries, including Eritrea. In the present study, we sought to determine the prevalence of specific transfusion transmitted infections (TTIs) and the associated risk factors among blood donors at a newly established regional blood transfusion center in Barentu, Eritrea.MethodsThe seroprevalence of markers for specific TTIs by sex, age, educational status, residence, occupation, and donor type was evaluated for donors who donated blood between July 2014 and April 2017. The relationship between TTIs and the stated factors was eval...
Source: BMC Hematology - March 12, 2019 Category: Hematology Source Type: research

Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine
ConclusionsHomozygosity for the mild β-globin gene IVS-I-6 allele was the major contributing factor for the TI phenotype among the study subjects. The role ofXmnI SNP and α-thalassemia mutations in ameliorating the TI phenotype was observed in few patients for each factor. The beta − 101 C >  T mutation was diagnosed in one patient in homozygote state for the first time in Palestine. (Source: BMC Hematology)
Source: BMC Hematology - February 18, 2019 Category: Hematology Source Type: research

Magnitude of elevated iron stores and risk associated in steady state sickle cell anemia Congolese children: a cross sectional study
ConclusionIn SCA children, hyperferritinemia requiring iron chelation is most strongly related to blood transfusion. This situation concerned almost one in five children in present study; this shows the magnitude of the problem which is underestimated. (Source: BMC Hematology)
Source: BMC Hematology - February 8, 2019 Category: Hematology Source Type: research

Effect of iron deficiency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia
AbstractBackgroundHemoglobin A1C (HbA1c) is the predominant hemoglobin found in HbA1 fractions. A1c assay is the recommended assay for diagnosing diabetes and any condition that changes red cell turnover such as Iron deficiency Anemia (IDA), will lead to spurious A1C results. Therefore, the present study was aimed at determining the effect of IDA on HbA1c in diabetic patients attending Black Lion Specialized Teaching Hospital, Addis Ababa, Ethiopia.MethodsA facility based comparative cross sectional study was conducted on 174 diabetic patients (87 with IDA and 87 without IDA) from April to July 2016. Socio demographic data...
Source: BMC Hematology - January 9, 2019 Category: Hematology Source Type: research

Prevalence of anemia among adults at Hawassa University referral hospital, Southern Ethiopia
AbstractIntroductionAnemia is a public health problem in Ethiopia. In spite of the fact that anemia is a common health burden with much severe consequences, the prevalence of the different types of anemia and its severity have not yet been well documented in different parts of the country. The study aimed to assess the prevalence of different types of anemia, including severity and association with age and sex of study population.Materials and methodsFour hundred anemic patients who are men and non-pregnant women above 15 years of age were selected from patients visiting the laboratory for Complete Blood Count (CBC) invest...
Source: BMC Hematology - January 8, 2019 Category: Hematology Source Type: research

Risk factors of metabolic syndrome among adult Sudanese sickle cell anemia patients
AbstractBackgroundSickle cell disease is a hereditary disorder characterized by haematological anaemia. Several studies assumed that adult sickle patients might develop metabolic syndrome features as hyperglycaemia, hypertension and dyslipidaemia. The aim of this study was to evaluate the metabolic syndrome risk factors among adult Sudanese with sickle cell anemia in the steady state.MethodsA prospective cross sectional study design was conducted among thirty adult patients with sickle cell anemia Hb SS (mean age 23  ± 6.1 years) and thirty healthy individuals matched for age and gender. Waist a...
Source: BMC Hematology - December 27, 2018 Category: Hematology Source Type: research

The role of haematological indices in predicting early iron deficiency among pregnant women in an urban area of Sri Lanka
AbstractBackgroundEarly detection and treatment of iron deficiency during pregnancy is crucial for optimum pregnancy outcomes. Anaemia is a late indictor of iron deficiency measured as Hb    10 mg/L were excluded (N = 20) from data analysis. Anaemia (Hb 
Source: BMC Hematology - December 22, 2018 Category: Hematology Source Type: research

Motivational factors for blood donation, potential barriers, and knowledge about blood donation in first-time and repeat blood donors
ConclusionOur findings suggest that public education on blood donation, regular prompts of donors to donate when there is a shortage, and friendly attitude of staff have the potential to motivate donors and eliminate barriers to blood donation. (Source: BMC Hematology)
Source: BMC Hematology - December 20, 2018 Category: Hematology Source Type: research

Infections in patients with aplastic Anemia in Chiang Mai University
AbstractBackgroundInfection is a major complication in aplastic anemia (AA) patients. Primary objectives of this study were to determine the prevalence of infections and to determine types of pathogens associated with infections in patients with AA. Secondary objectives were to evaluate overall survival after infections as well as risk factors of infections in patients with AA.MethodsThe authors retrospectively evaluated the infectious episodes (IEs), type of infections, associated pathogens, and outcomes of infections in patients with AA who were diagnosed and treated at Chiang Mai University between January 2010 and Dece...
Source: BMC Hematology - December 4, 2018 Category: Hematology Source Type: research

Recombinant activated factor VII (rFVIIa) in refractory haemorrhage for non-haemophiliacs: an eleven-year single-centre experience
AbstractBackgroundMassive bleeding is one of the commonest salvageable causes of death. The search for an ideal haemostatic agent during massive bleeding is still ongoing. One of the novel haemostatic medications is recombinant activated factor VII (rFVIIa). To date, the usage of rFVIIa during massive haemorrhage among non-haemophiliac patients remains off-label. The aim of this study is to report our experience in using rFVIIa to treat refractory bleeding.MethodsMedical records of all patients treated with rFVIIa for massive bleeding over an eleven-year period in a single institution were recorded. Treatment indications, ...
Source: BMC Hematology - November 23, 2018 Category: Hematology Source Type: research

A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania
We report the profile of SCD seen in the first 10  years at Muhimbili National Hospital (MNH).MethodsIndividuals seen at MNH known or suspected to have SCD were enrolled at clinic and laboratory testing for SCD, haematological and biochemical analyses done. Ethnicity was self-reported. Clinical and laboratory features of SCD were documented. Comparison was made with non-SCD population as well as within 3 different age groups (
Source: BMC Hematology - November 14, 2018 Category: Hematology Source Type: research

Prevalence of anemia and its associated factors in human immuno deficiency virus infected adult individuals in Ethiopia. A systematic review and meta-analysis
AbstractBackgroundAnemia is a common hematologic disorder among human Immunodeficiency virus (HIV) infected adult Individuals. However, there is no concrete scientific evidence established at national level in Ethiopia. Hence, this review gave special emphasis on Ethiopian HIV infected adult individuals to estimate pooled prevalence of anemia and its associated factors at national level.MethodsStudies were retrieved through search engines in PUBMED/Medline, Cochrane Library, and the web of science, Google and Google scholar following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P)...
Source: BMC Hematology - November 12, 2018 Category: Hematology Source Type: research

Prevalence, types and determinants of anemia among pregnant women in Sudan: a systematic review and meta-analysis
ConclusionThere is a high prevalence of anemia among pregnant in the different region of Sudan. While age and parity have no association with anemia, malaria infection was associated with anemia. Interventions to promote the strengthening of antenatal care, and access and adherence to nutrition, and malaria preventive measures are needed to reduce the high level of anemia among pregnant women in Sudan. (Source: BMC Hematology)
Source: BMC Hematology - November 8, 2018 Category: Hematology Source Type: research

Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood
This study evaluated the haemato-biochemical impact of SCT and asymptomatic malaria infections in citrate-phosphate-dextrose-adenine (CPDA-1) stored donor blood units.MethodsFifty-milliliters of sterile CPDA-1 anti-coagulated blood were drained into the sample pouch attached to the main blood bag. Ten units each of sickle cell/malaria negative, sickle cell and malaria positive blood were analyzed. Baseline and weekly haematological profiling and week 1, 3 and 5 concentrations of plasma haemoglobin, % haemolysis, sodium, potassium and chloride and lactate dehydrogenase (LDH) were assayed. Differences between baseline and we...
Source: BMC Hematology - November 6, 2018 Category: Hematology Source Type: research

Effect of iron-folic acid supplementation on change of hemoglobin among visceral Leishmaniasis patients in northwest Ethiopia: a retrospective follow up study
AbstractBackgroundAn individual with visceral Leishmaniasis (VL) commonly present with anemia and one of the VL treatment center in northwest Ethiopia has been recommended iron-folic acid supplementation to these patients. But there is no documented evidence whether iron-folic acid supplementation improves the hematological profile of patients. Therefore, the study aimed to assess change in hemoglobin (Hb) and its determinant factors among VL patients with and without iron-folic acid supplementation in northwest Ethiopia.MethodsA retrospective cohort study was conducted from January 2015 to December 2016. Data were entered...
Source: BMC Hematology - September 21, 2018 Category: Hematology Source Type: research

The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura
ConclusionHelicobacter pylori eradication significantly increases platelet counts in adult ITP patients. (Source: BMC Hematology)
Source: BMC Hematology - September 20, 2018 Category: Hematology Source Type: research

Diagnostic accuracy in field conditions of the sickle SCAN ® rapid test for sickle cell disease among children and adults in two West African settings: the DREPATEST study
AbstractBackgroundSickle cell disease (SCD) accounts for 5% of mortality in African children aged
Source: BMC Hematology - September 17, 2018 Category: Hematology Source Type: research

Biochemical and hematological changes among anemic and non-anemic pregnant women attending antenatal clinic at the Bolgatanga regional hospital, Ghana
AbstractBackgroundAnemia in pregnancy may not only be associated with maternal morbidity and mortality but can also be detrimental to the fetus. A definitive diagnosis of anemia is a pre-requisite to unravelling possible cause(s), to allow appropriate treatment intervention. It is hypothesised that measured hemoglobin (HGB), complemented by biochemical and other hematological parameters would enhance anemia diagnosis.MethodsThis was a cross-sectional study among 400 pregnant women comprising 253 anemic and 147 non-anemic pregnant women, attending an antenatal clinic at Bolgatanga Regional Hospital, Ghana. Venous blood was ...
Source: BMC Hematology - September 17, 2018 Category: Hematology Source Type: research

The clinical presentation, utilization, and outcome of individuals with sickle cell anaemia presenting to urban emergency department of a tertiary hospital in Tanzania
We describe the clinical presentation, resource utilization, and outcomes of SCA patients presenting to the emergency department (ED) at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania.MethodsThis was a prospective cohort study of consecutive patients with SCA presenting to ED between December 2014 and July 2015. Informed consent was obtained from all patients or patients ’ proxies prior to being enrolled in the study. A standardized case report form was used to record study information, including demographics, relevant clinical characteristics and overall patients outcomes. Categorical variables were co...
Source: BMC Hematology - September 17, 2018 Category: Hematology Source Type: research

Diagnostic accuracy in field conditions of the sickle SCAN ® rapid test for sickle cell disease among children and adults in two West African settings: the DREPATEST study
AbstractBackgroundSickle cell disease (SCD) accounts for 5% of mortality in African children aged
Source: BMC Hematology - September 17, 2018 Category: Hematology Source Type: research

Biochemical and hematological changes among anemic and non-anemic pregnant women attending antenatal clinic at the Bolgatanga regional hospital, Ghana
AbstractBackgroundAnemia in pregnancy may not only be associated with maternal morbidity and mortality but can also be detrimental to the fetus. A definitive diagnosis of anemia is a pre-requisite to unravelling possible cause(s), to allow appropriate treatment intervention. It is hypothesised that measured hemoglobin (HGB), complemented by biochemical and other hematological parameters would enhance anemia diagnosis.MethodsThis was a cross-sectional study among 400 pregnant women comprising 253 anemic and 147 non-anemic pregnant women, attending an antenatal clinic at Bolgatanga Regional Hospital, Ghana. Venous blood was ...
Source: BMC Hematology - September 17, 2018 Category: Hematology Source Type: research

The clinical presentation, utilization, and outcome of individuals with sickle cell anaemia presenting to urban emergency department of a tertiary hospital in Tanzania
We describe the clinical presentation, resource utilization, and outcomes of SCA patients presenting to the emergency department (ED) at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania.MethodsThis was a prospective cohort study of consecutive patients with SCA presenting to ED between December 2014 and July 2015. Informed consent was obtained from all patients or patients ’ proxies prior to being enrolled in the study. A standardized case report form was used to record study information, including demographics, relevant clinical characteristics and overall patients outcomes. Categorical variables were co...
Source: BMC Hematology - September 17, 2018 Category: Hematology Source Type: research

Seroprevalence and trends of transfusion transmitted infections at Harar blood bank in Harari regional state, Eastern Ethiopia: eight years retrospective study
AbstractBackgroundThe use of unscreened blood exposes the patient to many transfusion transmitted infections including Hepatitis B Virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and syphilis, among others. Thus, blood transfusion demands for meticulous pre-transfusion testing and screening. Trends of transfusion transmitted infections are important to take appropriate measures on blood bank services. Therefore the aim of this study was to assess seroprevalence and trends of transfusion transmitted infections at Harar blood bank in Harari regional state, Eastern Ethiopia from 2008 to 2015.MethodsA...
Source: BMC Hematology - September 15, 2018 Category: Hematology Source Type: research

Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo
ConclusionIn our study, albumin, manganese, cobalt and copper values did not differ between SCA children in steady state and Hb-AA children. The lack of differences in plasma elemental concentrations between the two groups in context of increased demands in the SCA group, may represent adequate compensatory intake or elemental dyshomeostasis in the SCA group. (Source: BMC Hematology)
Source: BMC Hematology - September 6, 2018 Category: Hematology Source Type: research

Evaluation and characterization of tumor lysis syndrome before and after chemotherapy among pediatric oncology patients in Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
ConclusionThere was high incidence of TLS irrespective of socio-demographic variation among study participants, suggesting that children with cancer are at risk of developing TLS. As TLS is a life-threatening complication of malignancies, early identification of patients at risk and reducing morbidity and mortality is crucially important. (Source: BMC Hematology)
Source: BMC Hematology - September 4, 2018 Category: Hematology Source Type: research

A new adult AML case with an extremely complex karyotype, remission and relapse combined with high hyperdiploidy of a normal chromosome set in secondary AML
ConclusionsTo the best of our knowledge, a comparable adult AML associated with such a CK, coexistence of 3q rearrangements with loss ofTP53 at diagnosis, and HH in secondary AML were not previously reported. Thus, the combination of the here seen chromosomal aberrations in adult primary AML seems to indicate for an adverse prognosis. (Source: BMC Hematology)
Source: BMC Hematology - August 31, 2018 Category: Hematology Source Type: research

Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study
AbstractBackgroundDengue infection patients are presented with acute febrile illness. Clinical presentations may mimic other infections. The serology for definite diagnosis is costly and inaccessible in many hospitals. We sought to identify the clinical features and hematologic parameters from a complete blood count (CBC) which distinguish dengue infection from other causes.MethodsThis was a retrospective single center study from Chiang Mai University Hospital. All patients who presented with acute fever between September 2013 and July 2015 were included. The diagnosis of dengue infection must be confirmed by serology. The...
Source: BMC Hematology - August 29, 2018 Category: Hematology Source Type: research

Rapid access clinic for unexplained lymphadenopathy and suspected malignancy: prospective analysis of 1000 patients
ConclusionsIn conclusion, we demonstrate that Oncologist-led rapid access clinics are successful concepts to assess patients with unexplained lymphadenopathy. Our data suggest that a routine use of FNA should be reconsidered in this setting. (Source: BMC Hematology)
Source: BMC Hematology - August 14, 2018 Category: Hematology Source Type: research

Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia
ConclusionBoth PCL and anti-factor XI inhibitors are two very rare entities. To the best of our knowledge, this is the first reported case of a factor XI inhibitor arising in the setting of PCL. Factor inhibitors should be suspected in patients whose monoclonal gammopathies are accompanied by bleeding manifestations. (Source: BMC Hematology)
Source: BMC Hematology - August 10, 2018 Category: Hematology Source Type: research

Identification of a novel mutation in the factor VIII gene causing severe haemophilia A
ConclusionThis novelF8 deletion as a cause of haemophilia A did not result in generation of inhibitory antibodies to Factor VIII treatment and may have impact on (prenatal) diagnosis, genetic counselling, and treatment decisions in the affected family as well as in other families diagnosed with thisF8 mutation. Finally, this novel mutation should be included in the panel of known genetic variants inF8 when searching for the genetic etiology in patients suspected of HEMA. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research

Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria
ConclusionsOur study recorded mostly young patients who received mostly whole blood. Most of the patients in the reproductive age group received transfusion for pregnancy and child-birth related cases. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research

Identification of a novel mutation in the factor VIII gene causing severe haemophilia A
ConclusionThis novelF8 deletion as a cause of haemophilia A did not result in generation of inhibitory antibodies to Factor VIII treatment and may have impact on (prenatal) diagnosis, genetic counselling, and treatment decisions in the affected family as well as in other families diagnosed with thisF8 mutation. Finally, this novel mutation should be included in the panel of known genetic variants inF8 when searching for the genetic etiology in patients suspected of HEMA. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research

Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria
ConclusionsOur study recorded mostly young patients who received mostly whole blood. Most of the patients in the reproductive age group received transfusion for pregnancy and child-birth related cases. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research