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Viruses, Vol. 13, Pages 1766: The Input of Structural Vaccinology in the Search for Vaccines against Bunyaviruses
s A significant increase in the number of viruses causing unexpected illnesses and epidemics among humans, wildlife and livestock has been observed in recent years. These new or re-emerging viruses have often caught the scientific community off-guard, without sufficient knowledge to combat them, as shown by the current coronavirus pandemic. The bunyaviruses, together with the flaviviruses and filoviruses, are the major etiological agents of viral hemorrhagic fever, and several of them have been listed as priority pathogens by the World Health Organization for which insufficient countermeasures exist. Based on new techn...
Source: Viruses - September 4, 2021 Category: Virology Authors: Alexandra Serris Tags: Review Source Type: research

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - September 22, 2021 Category: Drugs & Pharmacology Source Type: research

Threads Blocks Search Results For ' COVID ' And ' Vaccines ' , Upsetting Users
Threads Blocks Search Results For 'COVID' And 'Vaccines', Upsetting Users Authored by Bryan Jung via The Epoch Times, Threads, Meta's recent competitor to Twitter, is facing harsh criticism for blocking search results for terms related to the pandemic, including vaccines. The new text platform,…#bryanjung #epochtimes #threads #meta #twitter #threadsusersshocked #michaelrobertson #xmeta #misinfo #namesotherplatforms
Source: Reuters: Health - September 14, 2023 Category: Consumer Health News Source Type: news

Active search for leprosy cases in Midwestern Brazil: a serological evaluation of asymptomatic household contacts before and after prophylaxis with bacillus Calmette-Guérin.
This study aimed to determine the applicability of anti-PGL-1 IgM antibody detection, using the ML FLOW technique, as an assistant tool for the detection of leprosy infection in asymptomatic household contacts (AHHC) of multibacillary leprosy index cases from Midwest Brazil. Serological changes induced by the prophylaxis of these household contacts with Bacillus Calmette-Guérin (BCG) were also verified. A total of 91 AHHC were assessed, among which, 18.68% (n = 17) presented both positive bacilloscopy and positive anti-PGL-1 IgM serology. Positivity concordance between these two laboratorial exams (Kappa Index = 1; p <...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - June 11, 2013 Category: Tropical Medicine Authors: Limeira OM, Gomes CM, Morais OO, Cesetti MV, Alvarez RR Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Adoptive T-cell Transfer Therapy and Oncogene-Targeted Therapy for Melanoma: The Search for Synergy.
Abstract The clinical strengths of immunotherapy and small-molecule inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway appear to be largely complementary for the treatment of advanced melanoma. In current practice, most patients with BRAF V600 mutant melanomas will see both modalities. Several in vitro and in vivo studies suggest that combining immunotherapy with MAPK inhibition may have synergistic effects. First, mouse models show that adoptive cell therapy (ACT) can be enhanced by vaccination. Rapid tumor destruction by vemurafenib could provide a vaccine-like stimulus to adoptively transf...
Source: Clinical Cancer Research - October 1, 2013 Category: Cancer & Oncology Authors: Kwong ML, Neyns B, Yang JC Tags: Clin Cancer Res Source Type: research

The Holy Grail: The Search for Undiagnosed Cases Is Paramount in Improving the Cascade of Care Among People Living With HIV.
Abstract Highly Active Antiretroviral Therapy (HAART) has transformed the nature of HIV/AIDS from an imminent death sentence to a chronic manageable condition. There is a growing interest in the potential impact of "treatment as prevention" - a notion that expanded coverage with HAART would substantially reduce morbidity and mortality from HIV, and secondarily HIV transmission at the population level. However, undiagnosed and undocumented HIV cases cannot benefit from HAART and are more likely to experience HIV-related morbidity and untimely mortality. Late diagnosis of HIV remains prevalent and represents missed ...
Source: Canadian Journal of Public Health - November 8, 2013 Category: Global & Universal Authors: Eyawo O, Hogg RS, Montaner JS Tags: Can J Public Health Source Type: research

HIV: Antibodies advance the search for a cure
Deeks Efforts to make a prophylactic HIV vaccine have identified monoclonal antibodies that potently suppress viral replication. Studies in monkeys show that these reagents effectively treat HIV infection. See Article p.224 & Letter p.277
Source: Nature - October 30, 2013 Category: Research Authors: Louis J. PickerSteven G. Deeks Tags: News & Views Source Type: research

Routine childhood vaccination programme coverage, El Salvador, 2011-In search of timeliness.
Abstract While assessing immunization programmes, not only vaccination coverage is important, but also timely receipt of vaccines. We estimated both vaccination coverage and timeliness, as well as reasons for non-vaccination, and identified predictors of delayed or missed vaccination, for vaccines of the first two years of age, in El Salvador. We conducted a cluster survey among children aged 23-59 months. Caregivers were interviewed about the child immunization status and their attitudes towards immunization. Vaccination dates were obtained from children immunization cards at home or at health facilities. We refe...
Source: Vaccine - December 3, 2013 Category: Allergy & Immunology Authors: Suárez-Castaneda E, Pezzoli L, Elas M, Baltrons R, Crespin-Elías EO, Pleitez OA, de Campos MI, Danovaro-Holliday MC Tags: Vaccine Source Type: research

Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.
Abstract Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. Most of those which did not interfere, compete, inhibit or suppress their individual VHLLAI or FPIPS activity contained or displayed ...
Source: Vaccine - February 27, 2014 Category: Allergy & Immunology Authors: Bermúdez A, Calderon D, Moreno-Vranich A, Almonacid H, Patarroyo MA, Poloche A, Patarroyo ME Tags: Vaccine Source Type: research

Gene cooption in Mycobacteria and search for virulence attributes: Comparative proteomic analyses of Mycobacterium tuberculosis, Mycobacterium indicus pranii and other mycobacteria.
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a leading infectious disease taking one human life every 15s globally. Mycobacterium undergoes reductive evolution; the ancestors have bigger genome size and rich in metabolic pathways. Mycobacterium indicus pranii (MIP) is placed much above Mycobacterium tuberculosis (M.tb) in evolutionary scale and is a non-pathogenic, saprophytic mycobacterium. Our in silico comparative proteomic analyses of virulence factors of M.tb and their homologs in 12 different Mycobacterial species, including MIP, point toward gene cooption as an important mechanism in...
Source: International Journal of Medical Microbiology - May 29, 2014 Category: Microbiology Authors: Singh Y, Kohli S, Sowpati DT, Rahman SA, Tyagi AK, Hasnain SE Tags: Int J Med Microbiol Source Type: research

Medication errors in paediatrics: In search of a new vaccine.
PMID: 25282257 [PubMed - as supplied by publisher]
Source: Anales de Pediatria - October 1, 2014 Category: Pediatrics Authors: Piñeiro Pérez R Tags: An Pediatr (Barc) Source Type: research

Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection.
Abstract RV144 remains the only HIV-1 vaccine trial to demonstrate efficacy against HIV-1 acquisition. The prespecified analysis of immune correlates of risk showed that antibodies directed against the V1V2 region of gp120, in particular the IgG1 and IgG3 subclass mediating antibody-dependent cellmediated cytotoxicity, seem to play a predominant role in protection against HIV-1 acquisition and that plasma envelope (Env)-specific IgA antibodies were directly correlated with risk. RV144 and recent nonhuman primate challenge studies suggest that Env is essential, and perhaps sufficient, to induce protective antibody ...
Source: Annual Review of Medicine - October 17, 2014 Category: Journals (General) Authors: Kim JH, Excler JL, Michael NL Tags: Annu Rev Med Source Type: research

Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: search for the "magic bullet" to kill cccDNA.
This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis". PMID: 26476376 [PubMed - as supplied by publisher]
Source: Antiviral Research - October 14, 2015 Category: Virology Authors: Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M Tags: Antiviral Res Source Type: research

Abstract IA07: In search of racial disparities in HPV vaccination
Background: Racial disparities in cervical cancer deaths are longstanding, with African American and Latina women more likely to die from the disease. The advent of HPV vaccine created an opportunity to reduce or end these disparities, but only if uptake was either uniformly high across all females or higher among minority than non-minority females. Thus, interest in racial disparities in HPV vaccine coverage has been understandably high.Findings: Data from several sources show racial disparities and "reverse disparities" in HPV vaccination coverage. First, the most reliable national data are from the National Immunization...
Source: Cancer Epidemiology Biomarkers and Prevention - September 30, 2015 Category: Cancer & Oncology Authors: Brewer, N. T., Moss, J. L., Reiter, P. L. Tags: Vaccines and Immunoprevention: Oral Presentations - Invited Abstracts Source Type: research

Search Engine Ranking, Quality, and Content of Web Pages That Are Critical Versus Noncritical of Human Papillomavirus Vaccine
Online information can influence attitudes toward vaccination. The aim of the present study was to provide a systematic evaluation of the search engine ranking, quality, and content of Web pages that are critical versus noncritical of human papillomavirus (HPV) vaccination.
Source: Journal of Adolescent Health - November 7, 2015 Category: Child Development Authors: Linda Y. Fu, Kathleen Zook, Zachary Spoehr-Labutta, Pamela Hu, Jill G. Joseph Tags: Original article Source Type: research