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Therapy: Statin Therapy

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Total 12097 results found since Jan 2013.

Involvement of Pregnane X Receptor in the Impaired Glucose Utilization Induced by Atorvastatin in Hepatocytes.
In conclusion, atorvastatin impaired glucose utilization in hepatocytes via repressing GLUT2 and GCK expressions, which may be partly due to PXR activation. PMID: 26616219 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - November 23, 2015 Category: Drugs & Pharmacology Authors: Ling Z, Shu N, Xu P, Wang F, Zhong Z, Sun B, Li F, Zhang M, Zhao K, Tang X, Wang Z, Zhu L, Liu L, Liu X Tags: Biochem Pharmacol Source Type: research

Atorvastatin restricts HIV replication in CD4+ T cells by upregulation of p21
Conclusion: The results demonstrate a novel mechanism by which atorvastatin induced resistance of CD4+ T cells to HIV-1 infection via p21 upregulation and suggest that statins may hold particular promise for some HIV-infected individuals.
Source: AIDS - December 23, 2015 Category: Infectious Diseases Tags: Basic Science Source Type: research

Statins up-regulate SmgGDS through {beta}1-integrin/Akt1 pathway in endothelial cells
Conclusion These results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the β1-integrin/Akt1 pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins.
Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Minami, T., Satoh, K., Nogi, M., Kudo, S., Miyata, S., Tanaka, S.-i., Shimokawa, H. Tags: Vascular Biology Source Type: research

Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway.
This study investigates the mechanism underlying human lung cancer cell death by lovastatin and the role of the prostaglandin (PG)-synthesizing enzyme cyclooxygenase-2 (COX-2) in this process. In A549 and H358 lung carcinoma cells the lipophilic prodrug lovastatin lactone led to a concentration-dependent decrease of viability and induction of DNA fragmentation, whereas its HMG-CoA-inhibitory, ring-open acid form was inactive in this respect. Apoptotic cell death by lovastatin was accompanied by high intracellular levels of the lactone form, by upregulation of COX-2 mRNA and protein, as well as by increased formation of per...
Source: Oncotarget - February 12, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Id: 126: role of syndecan-1 in mechanical stress-induced lung endothelial cell inflammatory responses mediated by integrin beta4
Conclusion Our results implicate syndecan-1 as an important mediator of EC ITGB4 tyrosine phosphorylation affected by both simvastatin and mechanical-stress. These findings represent a novel area of investigation that may ultimately yield new therapeutic targets and strategies for patients with ventilator-induced lung injury, a form of ALI precipitated by excessive lung stretch.
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Chen, W., Dull, R., Jacobson, J. Tags: Pulmonary/Critical Care Source Type: research

AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability.
CONCLUSIONS: This study demonstrated that AMPKα2 deletion induces VSMC phenotypic switching and promotes features of atherosclerotic plaque instability in NF-κB-KLF4 dependent manner. PMID: 27439892 [PubMed - as supplied by publisher]
Source: Circulation Research - July 19, 2016 Category: Cardiology Authors: Ding Y, Zhang M, Zhang W, Lu Q, Cai Z, Song P, Okon IS, Xiao L, Zou MH Tags: Circ Res Source Type: research

Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function.
In this study, we found that IRF4 expression was remarkably suppressed during the development of MDSCs in the tumor microenvironment. Both the mRNA and protein levels of IRF4 in MDSCs were gradually reduced, depending on the development of tumors in the 4T1 model. siRNA-mediated knockdown of IRF4 in bone marrow cells promoted the differentiation of PMN-MDSCs. Similarly, IRF4 inhibition in bone marrow cells using simvastatin, which has been known to inhibit IRF4 expression, increased PMN-MDSC numbers. In contrast, IRF4 overexpression in bone marrow cells inhibited the total numbers of MDSCs, especially PMN-MDSCs. Notably, t...
Source: Journal of Leukocyte Biology - September 5, 2016 Category: Hematology Authors: Nam S, Kang K, Cha JS, Kim JW, Lee HG, Kim Y, Yang Y, Lee MS, Lim JS Tags: J Leukoc Biol Source Type: research

Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3 β-PP2Ac-NF-κB Signaling Axis
by Xiao-min Ren, Guang-feng Zuo, Wen Wu, Jie Luo, Peng Ye, Shao-liang Chen, Zuo-ying Hu Recent studies reported that atorvastatin (ATOR) alleviated progression of experimental diabetic cardiomyopathy (DCM), possibly by protecting against apoptosis. However, the underlying mechanisms of this protective effect remain unclear. Therefore, our study investigated the role of the glycogen s ynthase kinase (GSK)-3β-protein phosphatase 2A(PP2A)-NF-κB signaling pathway in the anti-apoptotic and cardioprotective effects of ATOR on cardiomyocytes cultured in high glucose (HG) and in DCM. Our results showed that, in HG-cultured card...
Source: PLoS One - November 15, 2016 Category: Biomedical Science Authors: Xiao-min Ren Source Type: research

Pitavastatin Suppresses Hyperglycemia-induced Podocyte Injury via Bone Morphogenetic Protein-7 Preservation.
CONCLUSION: Pitavastatin attenuates hyperglycemia-induced podocyte injury via Rho-Rho kinase-dependent BMP-7 preservation. This article is protected by copyright. All rights reserved. PMID: 27997722 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - December 19, 2016 Category: Drugs & Pharmacology Authors: Ohigashi M, Kobara M, Takahashi T, Toba H, Wada T, Nakata T Tags: Clin Exp Pharmacol Physiol Source Type: research

Pravastatin activates activator protein 2 alpha to argument the angiotensin II-induced abdominal aortic aneurysms.
In conclusion, pravastatin promotes AAA formation through AMPKα2-dependent AP-2α activations. PMID: 28179583 [PubMed - as supplied by publisher]
Source: Oncotarget - February 11, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Rac1 GTPase regulates 11{beta} hydroxysteroid dehydrogenase type 2 and fibrotic remodeling Molecular Bases of Disease
In conclusion, Rac1 GTPase regulates 11β-HSD2 expression, MR activation, and MR-mediated pro-fibrotic signaling.
Source: Journal of Biological Chemistry - May 5, 2017 Category: Chemistry Authors: Daniel Lavall, Pia Schuster, Nadine Jacobs, Andrey Kazakov, Michael Bohm, Ulrich Laufs Tags: Signal Transduction Source Type: research

(In)Equity in Primary Prevention Statin Treatment Among Diabetics
None
Source: Journal of Clinical Lipidology - May 1, 2017 Category: Lipidology Authors: Christopher Latanich, Shermeen Memon, Sara Sirna Source Type: research

Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells
by Ae-Rang Hwang, Jung-Hwa Han, Jae Hyang Lim, Young Jin Kang, Chang-Hoon Woo Advanced glycation endproduct (AGE)-induced vascular smooth muscle cell (VSMC) proliferation and reactive oxygen species (ROS) production are emerging as important mechanisms of diabetic vasculopathy, but little is known about the molecular mechanism responsible for the antioxidative effects of st atins on AGEs. It has been reported that statins exert pleiotropic effects on the cardiovascular system due to decreases in AGE-induced cell proliferation, migration, and vascular inflammation. Thus, in the present study, the authors investigated the m...
Source: PLoS One - May 22, 2017 Category: Biomedical Science Authors: Ae-Rang Hwang Source Type: research

Statin Regulated ERK5 Stimulates Tight Junction Formation and Reduces Permeability in Human Cardiac Endothelial Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - June 22, 2017 Category: Cytology Authors: Emma L. Wilkinson, James E. Sidaway, Michael J. Cross Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Atorvastatin ameliorates LPS ‐induced inflammatory response by autophagy via AKT/mTOR signaling pathway
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 3, 2017 Category: Biochemistry Authors: Fei Han, Qing ‐Qing Xiao, Shi Peng, Xin‐Yu Che, Li‐Sheng Jiang, Qin Shao, Ben He Tags: Article Source Type: research