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Nutrition: Potassium
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Total 1055 results found since Jan 2013.
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.
CONCLUSIONS: There is very low-quality evidence that is insufficient to determine the effects of systemic antibiotics on adults with symptomatic apical periodontitis or acute apical abscess.
PMID: 30259968 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 27, 2018 Category: General Medicine Authors: Cope AL, Francis N, Wood F, Chestnutt IG Tags: Cochrane Database Syst Rev Source Type: research
Flupirtine and antihistamines exert synergistic anti-nociceptive effects in mice
ConclusionsFlupirtine and antihistamines produced synergistic analgesic effects in all the above pain models. The analgesic effects of antihistamines were partially mediated by Kv7/M channels, and the activation of Kv7/M channels may be partly responsible for the synergistic analgesic effects between flupirtine and antihistamines.
Source: Psychopharmacology - February 8, 2023 Category: Psychiatry Source Type: research
Post Hoc Subanalysis of Two Randomized, Controlled Phase 3 Trials Evaluating Diclofenac Potassium for Oral Solution: Impact of Migraine-Associated Nausea and Prior Triptan Use on Efficacy.
CONCLUSIONS: Nausea at the time of dosing does not diminish the effectiveness of diclofenac potassium for oral solution. The rapid absorption profile may enhance the effectiveness in patients with nausea. Prior triptan use predicted poorer headache response at 2 hours postdose, suggesting the possibility of a subset of patients who are more likely to be refractory to both triptans and diclofenac. Diclofenac potassium for oral solution is effective in triptan-naïve patients but no reliable inference can be made from this study as to about how to order treatment.
PMID: 28386945 [PubMed - as supplied by publisher]
Source: Headache - April 6, 2017 Category: Neurology Authors: Lipton RB, Schmidt P, Diener HC Tags: Headache Source Type: research
The transcription factor C/EBP{beta} in the dorsal root ganglion contributes to peripheral nerve trauma-induced nociceptive hypersensitivity
We report that peripheral nerve trauma caused by chronic constriction injury (CCI) increased the abundance of the transcription factor C/EBPβ (CCAAT/enhancer binding protein β) in the DRG. Blocking this increase mitigated the development and maintenance of CCI-induced mechanical, thermal, and cold pain hypersensitivities without affecting basal responses to acute pain and locomotor activity. Conversely, mimicking this increase produced hypersensitivity to mechanical, thermal, or cold pain. In the ipsilateral DRG, C/EBPβ promoted a decrease in the abundance of the voltage-gated potassium channel subunit Kv1.2...
Source: Signal Transduction Knowledge Environment - July 11, 2017 Category: Science Authors: Li, Z., Mao, Y., Liang, L., Wu, S., Yuan, J., Mo, K., Cai, W., Mao, Q., Cao, J., Bekker, A., Zhang, W., Tao, Y.-X. Tags: STKE Research Articles Source Type: news
The transcription factor C/EBP β in the dorsal root ganglion contributes to peripheral nerve trauma-induced nociceptive hypersensitivity.
We report that peripheral nerve trauma caused by chronic constriction injury (CCI) increased the abundance of the transcription factor C/EBPβ (CCAAT/enhancer binding protein β) in the DRG. Blocking this increase mitigated the development and maintenance of CCI-induced mechanical, thermal, and cold pain hypersensitivities without affecting basal responses to acute pain and locomotor activity. Conversely, mimicking this increase produced hypersensitivity to mechanical, thermal, or cold pain. In the ipsilateral DRG, C/EBPβ promoted a decrease in the abundance of the voltage-gated potassium channel subunit Kv1.2 and μ opio...
Source: Science Signaling - July 11, 2017 Category: Biomedical Science Authors: Li Z, Mao Y, Liang L, Wu S, Yuan J, Mo K, Cai W, Mao Q, Cao J, Bekker A, Zhang W, Tao YX Tags: Sci Signal Source Type: research
Cannabinoids-induced peripheral analgesia depends on activation of BK channels.
Abstract
The endogenous cannabinoid system is involved in the physiological inhibitory control of pain and is of particular interest for the development of therapeutic approaches for pain management. Selective activation of the peripheral CB1 cannabinoid receptor has been shown to suppress the heightened firing of primary afferents, which is the peripheral mechanism underlying neuropathic pain after nerve injury. However, the mechanism underlying this effect of CB1 receptor remains unclear. The large-conductance calcium-activated potassium (BK) channels have been reported to participate in anticonvulsant and vasor...
Source: Brain Research - January 4, 2019 Category: Neurology Authors: Li Y, Zhang L, Wu Y, Zheng Q, Chen M, Qian Z, Wei C, Han J, Liu Z, Ren W, Lui Y Tags: Brain Res Source Type: research
The Interventionalist Refuses Angiography, and even to speak to the Emergency Physician
A recent residency graduate, let ' s call her " The Graduate " or " TG, " texted me these ECGs from somewhere far away across the country, in real time, in the hopes of being able to persuade the interventionalist to take the patient to the cath lab.CaseAn otherwise healthy middle-aged patient presented with chest pain of uncertain duration.Here is the initial ED ECG (I apologize for the poor quality of these images -- they were mobile phone photos of computer screens, texted to me -- but they are good enough!):What do you see?There was a second ECG after the patient had symptom resolution:What do you see?This is what TG a...
Source: Dr. Smith's ECG Blog - January 11, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Altered Activity of SK Channel Underpins Morphine Withdrawal Relevant Psychiatric Deficiency in Infralimbic to Accumbens Shell Pathway
In this study, we investigated the role of the small conductance calcium-activated potassium channels (SK channels) in NAc and mPFC after morphine withdrawal. Action potential (AP) firing of neurons in the NAc shell was enhanced via the downregulations of the SK channels after morphine withdrawal. Furthermore, the expression of SK2 and SK3 subunits in the NAc was significantly reduced after 3 weeks of morphine withdrawal, but was not altered in the dorsal striatum. In mPFC, the SK channel subunits were differentially expressed. To be specific, the expression of SK3 was upregulated, while the expression of SK2 was unchanged...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research
Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF- α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels
In conclusion, thiamine, riboflavin, and nicotinamide exhibit antinociceptive activity in the neuropathic pain model induced by paclitaxel. Inhibition of TNF-α and CXCL-1 production in DRG and thalamus, as well as activation of ATP-sensitive potassium channels, underly their antinociceptive activity.
Source: Inflammopharmacology - August 5, 2019 Category: Drugs & Pharmacology Source Type: research
Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice.
Conclusions: ELS-induced visceral pain and visceral hypersensitivity are associated with the underfunction of SK2 channels in the spinal DH.
PMID: 33029124 [PubMed - in process]
Source: Neural Plasticity - October 10, 2020 Category: Neurology Authors: Wu K, Gao JH, Hua R, Peng XH, Wang H, Zhang YM Tags: Neural Plast Source Type: research
Fast A-type currents shape a rapidly adapting form of delayed short latency firing of excitatory superficial dorsal horn neurons that express the NPY Y1 receptor
This article is protected by copyright. All rights reserved.PMID:33768539 | DOI:10.1113/JP281033
Source: The Journal of Physiology - March 26, 2021 Category: Physiology Authors: Ghanshyam P Sinha Pranav Prasoon Bret N Smith Bradley K Taylor Source Type: research
What Conditions is Erythema Nodosum Associated With?
Discussion
Erythema nodosum (EN) is a common dermatological eruption characterized by inflammatory nodules of the subcutaneous fat (panniculitis) on the extensor surfaces of the extremities especially the shins, thighs, and forearms. They are usually painful, nodular, bilateral and multiple. They can be found on other areas and be unilateral. They can be red, purple or blackish. They usually resolve without problems in 3-6 weeks.
Diagnosis is usually clinical but biopsy may be needed if there is atypical presentation or history, physical examination or laboratory testing reveals potential underlying diseases. Treatment is...
Source: PediatricEducation.org - July 24, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Evaluation of stress biomarkers and electrolytes in saliva of patients undergoing fixed orthodontic treatment.
CONCLUSIONS: The present data indicate that orthodontic patients are under emotional stress only during the period of higher pain experience, which could also disrupt the masticatory performance. However, these alterations were not correlated with a single measurement of stress-related biomarkers in saliva, suggesting that these solitary endocrine measurements are not adequate to predict the temporary pain and masticatory limitation experimented by patients undergoing orthodontic treatment.
PMID: 29943947 [PubMed - in process]
Source: Minerva Stomatologica - June 28, 2018 Category: Dentistry Tags: Minerva Stomatol Source Type: research
