Altered Activity of SK Channel Underpins Morphine Withdrawal Relevant Psychiatric Deficiency in Infralimbic to Accumbens Shell Pathway

In this study, we investigated the role of the small conductance calcium-activated potassium channels (SK channels) in NAc and mPFC after morphine withdrawal. Action potential (AP) firing of neurons in the NAc shell was enhanced via the downregulations of the SK channels after morphine withdrawal. Furthermore, the expression of SK2 and SK3 subunits in the NAc was significantly reduced after 3 weeks of morphine withdrawal, but was not altered in the dorsal striatum. In mPFC, the SK channel subunits were differentially expressed. To be specific, the expression of SK3 was upregulated, while the expression of SK2 was unchanged. Furthermore, the AP firing in layer 5 pyramidal neurons of the infralimbic (IL) cortex was decreased via the upregulations of the SK channel-related tail current after 3 weeks of morphine withdrawal. These results suggest that the SK channel plays a specific role in reward circuits following morphine exposure and a period of drug withdrawal, making it a potential target for the prevention of relapse.IntroductionDrug addiction can be viewed as a mental health disorder caused by maladaptive neural plasticity (1). It involves long-term and persistent dysregulation of neural circuits, particularly in motivational systems and reward systems (2). Opioids, including morphine, are the first-line choice for the management of chronic pain and moderate-to-severe acute pain in both cancer and noncancer patients (3). However, repeated morphine exposure can lead to addi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Conclusion Learning how to pay attention to our attention (meta-attention) can be transformative. Using principles from cognitive science, we can create a comprehensive approach (attention capital theory in medicine) to reclaim the meaning and joy that has been depleted from our profession. Increasing the difficulty of our work to match our skill level, delegating low-level tasks to help us focus on critical steps in our physician zone, creating rules to eliminate distractions, and noticing both the wonder and suffering around us may be more important than resilience training or wellness modules. Although well-intention...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Physicians Burnout physician burnout physician wellness Sanj Katyal Source Type: blogs
Cliffside Malibu does not condone the use of the term “addict” when referring to people suffering from the disorder of addiction. However, we do understand that others still may use the term in order to find information. Many people may find themselves asking the question, “am I an opioid addict?” if they feel as if their use has spiraled out of control. There are many ways to find out if you may have become addicted to opioids, as well as ways to get help and find treatment. How Opioid Addiction Begins Nearly 80% of heroin users started with prescription opioids, which puts prescription drugs and ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals addiction treatment opioid opioid crisis opioids pharmaceutical addiction pharmaceutical drug abuse treatment Source Type: blogs
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroinfla...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
 Former Congressman Patrick Kennedy joins our hosts to talk about mental health and addiction parity, both at the federal and state levels. He shares information about new initiatives, dontdenyme.org and parityregistry.org, designed to help consumers file appeals on their own, if they feel they’ve been wrongly denied coverage by their insurance companies. They speak candidly about the problems faced with regard to parity by those who live with mental health or addiction issues. And finally, they talk about how anyone can become an advocate. Subscribe to Our Show! And Remember to Review Us! About O...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Interview Policy and Advocacy The Psych Central Show Gabe Howard Parity Patrick Kennedy Vincent M. Wales Source Type: blogs
You're reading 24 Creative Geniuses Who Inspire Boldness (Even if You’re Shy or Socially Anxious), originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. “Any step in the direction of expressing your creative impulses is a step in the direction of actualizing the genius that resides within you.” -Dr. Wayne Dyer Genius? Expressing creative impulses? Isn’t that aiming a little high? I’m just trying to survive. If this represents the tired record playing in your mind, stick around for some major i...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: confidence creativity featured self improvement best inspirational quotes best self-improvement blogs creative genius how to be bold how to build confidence pickthebrain self confidence Source Type: blogs
Repeated adverse childhood experiences (ACEs) can change the body, brain, nervous system and ultimately an entire life. You may be incredibly resilient. The person with an easier life and more harmonious childhood may appear more resilient, but they have not been tested in the same ways. You may be an incredibly resourceful person — likewise, life has probably helped you hone these skills. You may be highly intelligent, empathic, kind or creative. You may feel very connected to your spiritual self. You may be navigating life from your heart and your smarts and yet wonder it’s not coming together for you. Trauma...
Source: Psych Central - Category: Psychiatry Authors: Tags: Abuse Children and Teens Disorders Domestic Violence Family General Parenting Psychology PTSD Self-Esteem ACES bullying Child Abuse complex post-traumatic stress disorder cortisol Dissociation Fight or Flight Nervous Syst Source Type: news
00:00 to 02.26—Dr. Bihari gives his background and credentials. Dr. Bihari: My medical training started at Harvard Medical School. I graduated in 1957. Then I trained in Internal Medicine at one of the Harvard teaching hospitals in Boston, Beth Israel, and then in Neurology at Massachusetts General in Boston. Then I went to the National Institutes of Health for two years doing brain physiology—brain research. I did another residency training in Psychiatry in New York, at Columbia Presbyterian Medical Center and then, over the following five or six years, I got very involved in working in Drug Addiction. By 197...
Source: HONEST MEDICINE: My Dream for the Future - Category: Consumer Health News Authors: Tags: Anecdotal Treatments HONEST MEDICINE Integrative Medicine Low Dose Naltrexone Obituaries Source Type: blogs
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