Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF- α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels

In conclusion, thiamine, riboflavin, and nicotinamide exhibit antinociceptive activity in the neuropathic pain model induced by paclitaxel. Inhibition of TNF-α and CXCL-1 production in DRG and thalamus, as well as activation of ATP-sensitive potassium channels, underly their antinociceptive activity.
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research