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Therapy: Vagus Nerve Stimulation Therapy
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Total 158 results found since Jan 2013.
Vagus Nerve Stimulation Delivered During Motor Rehabilitation Improves Recovery in a Rat Model of Stroke
Neural plasticity is widely believed to support functional recovery following brain damage. Vagus nerve stimulation paired with different forelimb movements causes long-lasting map plasticity in rat primary motor cortex that is specific to the paired movement. We tested the hypothesis that repeatedly pairing vagus nerve stimulation with upper forelimb movements would improve recovery of motor function in a rat model of stroke. Rats were separated into 3 groups: vagus nerve stimulation during rehabilitation (rehab), vagus nerve stimulation after rehab, and rehab alone. Animals underwent 4 training stages: shaping (motor ski...
Source: Neurorehabilitation and Neural Repair - August 13, 2014 Category: Neurology Authors: Khodaparast, N., Hays, S. A., Sloan, A. M., Fayyaz, T., Hulsey, D. R., Rennaker, R. L., Kilgard, M. P. Tags: Basic Research Articles Source Type: research
L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response.
This study investigated the role of L-PGDS in cerebral I/R and whether this process was involved in the mechanism of VNS-mediated neuroprotection. Male Sprague-Dawley rats were pretreated with a lentiviral vector (LV) through intracerebroventricular injection, followed by middle cerebral artery occlusion (MCAO) and VNS treatment. The expression of L-PGDS in the peri-infarct cortex was examined. The localization of L-PGDS was determined using double immunofluorescence staining. Neurologic scores, infarct volume and neuronal apoptosis were evaluated at 24 h after reperfusion. The expression of apoptosis-related molecules wa...
Source: Neurochemical Research - November 28, 2016 Category: Neuroscience Authors: Zhang L, Ma J, Jin X, Jia G, Jiang Y, Li C Tags: Neurochem Res Source Type: research
Combining Transcutaneous Vagus Nerve Stimulation and Upper-Limb Robotic Rehabilitation in Chronic Stroke Patients
Introduction And Aims: Vagus nerve stimulation (VNS) is a promising approach for enhancing rehabilitation effects in stroke patients, but the invasiveness of this technique reduces its clinical application. Recently, a non-invasive technique for stimulating vagus nerve has been developed. We evaluated safety, feasibility, and efficacy of noninvasive VNS combined with robotic rehabilitation for improving upper limb functionality in chronic stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: F. Capone, S. Miccininilli, G. Pellegrino, L. Zollo, E. Guglielmelli, S. Sterzi, V. Di Lazzaro Source Type: research
FDA OKs First Vagus Nerve Stimulation System for Stroke Rehab FDA OKs First Vagus Nerve Stimulation System for Stroke Rehab
The US Food and Drug Administration has approved a first-of-its kind vagus nerve stimulation system to treat moderate-to-severe upper extremity motor deficits associated with chronic ischemic stroke.FDA Approvals
Source: Medscape Neurology and Neurosurgery Headlines - August 27, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news
Vagus Nerve Stimulation Paired with Upper-Limb Rehabilitation After Stroke: Two- and Three-Year Follow-up from the Pilot Study
More than 50% of people post-stroke have significant limitations in their ability to carry out day-to-day functional activities long term and are unable to effectively incorporate their impaired hand and arm during everyday tasks1,2. The disabling effects typically persist for many years after the initial stroke3,4. People with stroke often compensate by using the less impaired limb for daily activities, which may precipitate learned non-use and result in further deterioration of arm and hand function5.
Source: Archives of Physical Medicine and Rehabilitation - March 29, 2023 Category: Rehabilitation Authors: Gerard E. Francisco, Navzer Engineer, Jesse Dawson, Teresa J. Kimberley, Steven Cramer, Cec ília N. Prudente, David Pierce, Brent W. Tarver, Reema H. Adham Hinds, Ann Van de Winckel, Nuray Yozbatiran Tags: Original Research Source Type: research
Mayo Clinic Minute: How vagus nerve stimulation can help some patients improve their recovery after stroke
A vagus nerve stimulation device, approved by the Food and Drug Administration, is being used in rehabilitation to help patients recovering from an ischemic stroke. If a patient is having trouble using their hand or arm after a stroke, this stimulation device helps create new pathways in the brain as the person performs exercises. This can help the person regain function faster than rehabilitation alone. Dr. Jonathon Parker, a Mayo Clinic neurosurgeon, discusses how the…
Source: News from Mayo Clinic - May 2, 2023 Category: Databases & Libraries Source Type: news
Application of vagus nerve stimulation on the rehabilitation of upper limb dysfunction after stroke: a systematic review and meta-analysis
ConclusionVNS is an effective and safe treatment for upper extremity motor dysfunction after a stroke. For the functional restoration of the upper extremities, noninvasive integrated therapy and lower-frequency VNS may be more effective. In the future, further high-quality studies with larger study populations, more comprehensive indicators, and thorough data are required to advance the clinical application of VNS.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023399820.
Source: Frontiers in Neurology - June 21, 2023 Category: Neurology Source Type: research
Left or right ear? A neuroimaging study using combined taVNS/fMRI to understand the interaction between ear stimulation target and lesion location in chronic stroke
Implanted vagus nerve stimulation (VNS) and transcutaneous auricular VNS (taVNS) have been primarily administered clinically to the unilateral-left vagus nerve. This left-only convention has proved clinically beneficial in brain disorders. However, in stroke survivors, the presence of a lesion in the brain may complicate VNS-mediated signaling, and it is important to understand the laterality effects of VNS in stroke survivors to optimize the intervention.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 27, 2023 Category: Neurology Authors: Xiaolong Peng, Brenna Baker-Vogel, Mutaz Sarhan, Edward B. Short, Wenzhen Zhu, Hesheng Liu, Steven Kautz, Bashar W. Badran Source Type: research
Neurostimulation After Stroke
This article explores its applications in upper and lower limb stroke rehabilitation. The authors review various methods to target the corticomotor system, including transcranial direct current stimulation, repetitive transcranial magnetic stimulation, and vagus nerve stimulation. In addition, the authors review the use of peripheral neuromuscular electrical stimulation for therapeutic and assistive purposes, including transcutaneous electrical nerve stimulation, neuromuscular electrical stimulation, and functional electrical stimulation. For each, the authors examine the potential benefits, limitations, safety considerations, and FDA status.
Source: Physical Medicine and Rehabilitation Clinics of North America - August 21, 2023 Category: Rehabilitation Authors: Hala Osman, Ricardo Siu, Nathan S. Makowski, Jayme S. Knutson, David A. Cunningham Source Type: research
Vagus Nerve Stimulation Paired with Mobility Training in Chronic Ischemic Stroke: A Case Report
CONCLUSION: The participant demonstrated improved gait speed and timed distance after VNS-paired mobility training. Randomized, blinded trials are needed to determine treatment efficacy.IMPACT: This is the first documented case of VNS-paired mobility training in an individual with chronic poststroke gait impairments. VNS paired with mobility training may improve poststroke gait impairments.PMID:37669130 | DOI:10.1093/ptj/pzad097
Source: Health Physics - September 5, 2023 Category: Physics Authors: Teresa J Kimberley Cec ília N Prudente Navzer D Engineer David Alexander Dickie Teresa A Bisson Ann Van de Winckel Source Type: research
Vagal Stimulation May Help Upper Limb Stroke Recovery
Patients with upper limbs affected by ischemic stroke who paired traditional rehabilitation exercises with pulsed vagus nerve stimulation boosted functional scores significantly higher than did those who performed exercises alone in a small, randomized pilot trial.
Source: Caring for the Ages - August 1, 2015 Category: Health Management Authors: Michele G. Sullivan Source Type: news
Vagus nerve stimulation shows progress in stroke patient recovery
Vagus nerve stimulation (VNS) technology could help improve the lives of hundreds of thousands of people who suffer weakness and paralysis caused by strokes, new research suggests. The study marks the first time that VNS has been tested in individuals recovering from stroke.
Source: ScienceDaily Headlines - December 9, 2015 Category: Science Source Type: news
Vagus Nerve Stimulation during Rehabilitative Training Enhances Recovery of Forelimb Function after Ischemic Stroke in Aged Rats
Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury, but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength.
Source: Neurobiology of Aging - April 6, 2016 Category: Neuroscience Authors: Seth A. Hays, Andrea Ruiz, Thelma Bethea, Navid Khodaparast, Jason B. Carmel, Robert L. Rennaker, Michael P. Kilgard Source Type: research
Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke
Conclusion Our data suggest that the neuroprotective role of a series of nVNS administrations during MCA occlusion, spatially correlates with protection of BBB integrity from damage and reduction of infarct extent induced by ischemic stroke.
Source: Brain Stimulation - February 16, 2018 Category: Neurology Source Type: research
