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Total 731 results found since Jan 2013.

Post-ischemic protein restriction induces sustained neuroprotection, neurological recovery, brain remodeling, and gut microbiota rebalancing
CONCLUSION: Moderate dietary protein restriction initiated post-ischemic stroke induces neurological recovery, brain remodeling, and neuroplasticity in mice by mechanisms involving antiinflammation and, in the post-acute phase, commensal gut microbiota rebalancing.PMID:34848338 | DOI:10.1016/j.bbi.2021.11.016
Source: Brain, Behavior, and Immunity - December 1, 2021 Category: Neurology Authors: Tayana Silva de Carvalho Vikramjeet Singh Ayan Mohamud Yusuf Jing Wang Adriana R Schultz Moreira Eduardo H Sanchez-Mendoza Maryam Sardari Luiza M Nascentes Melo Thorsten R Doeppner Jan Kehrmann Rene Scholtysik Ludger Hitpass Matthias Gunzer Dirk M Hermann Source Type: research

Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury
Ischemic stroke is one of the leading causes of morbidity and mortality globally. Hundreds of clinical trials have proven ineffective in bringing forth a definitive and effective treatment for ischemic stroke, except a myopic class of thrombolytic drugs. That, too, has little to do with treating long-term post-stroke disabilities. These studies proposed diverse options to treat stroke, ranging from neurotropic interpolation to venting antioxidant activity, from blocking specific receptors to obstructing functional capacity of ion channels, and more recently the utilization of neuroprotective substances. However, state of t...
Source: Frontiers in Immunology - October 7, 2021 Category: Allergy & Immunology Source Type: research

Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice
AbstractOxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention.Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory has reported protective effects of pre-treatment withO. basilicum in experimental stroke, but its curative (post-treatment) effects in ischemic stroke have not been documented. Hence, the present study was aimed to evaluate the effect ofO. basilicum leaf extract (OBLE) on functional outcomes following cer...
Source: Metabolic Brain Disease - March 15, 2018 Category: Neurology Source Type: research

Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models
Conclusions: The diverse and broad actions of polydatin suggested that it could be a multiple targeting neuroprotective agent in ameliorating the detrimental effects of MCAO, such as neuroinflammation, oxidative stress and neuronal apoptosis. As repetitive clinical trials of neuroprotectants targeting a single step of stroke pathological process have failed previously, our results suggested that a neuroprotective strategy of acting at different stages may be more advantageous to intervene in the vicious cycles in MCAO.
Source: Frontiers in Pharmacology - June 25, 2019 Category: Drugs & Pharmacology Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject.Graphical abstract
Source: Biomedicine and Pharmacotherapy - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization.
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. PMID: 32028240 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 2, 2020 Category: Drugs & Pharmacology Authors: Wang Y, Xiao G, He S, Liu X, Zhu L, Yang X, Zhang Y, Orgah J, Feng Y, Wang X, Zhang B, Zhu Y Tags: Biomed Pharmacother Source Type: research

Protective Effects and Network Analysis of Ginsenoside Rb1 Against Cerebral Ischemia Injury: A Pharmacological Review
Ischemic stroke is a leading cause of death and disability worldwide. Currently, only a limited number of drugs are available for treating ischemic stroke. Hence, studies aiming to explore and develop other potential strategies and agents for preventing and treating ischemic stroke are urgently needed. Ginseng Rb1 (GRb1), a saponin from natural active ingredients derived from traditional Chinese medicine (TCM), exerts neuroprotective effects on the central nervous system (CNS). We conducted this review to explore and summarize the protective effects and mechanisms of GRb1 on cerebral ischemic injury, providing a valuable r...
Source: Frontiers in Pharmacology - July 2, 2021 Category: Drugs & Pharmacology Source Type: research

Protective effects of Japanese sake yeast on depressive-like behaviors, oxidative stress and inflammatory parameters in a rat model of global cerebral ischemia/reperfusion
This study evaluates the effects of sake yeast on depressive-like behaviors, oxidative stress and inflammatory parameters in a rat model of global cerebral ischemia/reperfusion. Rats were divided into four groups, including 1) control: without bilateral common carotid artery occlusion (BCCAO) and sake supplement, 2) Ischemia group: rats induced with BCCAO and lack of therapeutic supplement, and 3 and 4) Ischemia + sake groups: rats induced with BCCAO and treated with 25 and 50 mg/kg sake yeast, respectively. Depressive-like behaviors antioxidant enzymes activities were assessed. The induction of stroke increased oxidant st...
Source: Biochemical and Biophysical Research communications - July 7, 2023 Category: Biochemistry Authors: Maryam Vaghari Akbar Hajizadeh Moghaddam Mojtaba Ranjbar Nasrollah Moradikor Source Type: research

The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence
Conclusions: Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577 Received: 01 June 2016 Revised: 26 February 2017 Acce...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Molecules, Vol. 23, Pages 2401: Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways
Xiaobo Sun Ischemic stroke is a clinically common cerebrovascular disease whose main risks include necrosis, apoptosis and cerebral infarction, all caused by cerebral ischemia and reperfusion (I/R). Ischemia and reperfusion-induced injury of or apoptosis inhibition in human brain tissue may exert an irreplaceable protective effect on ischemic nerves. This process has particular significance for the treatment of stroke patients. However, the development of neuroprotective drugs remains challenging. Radix Scrophulariae, traditionally considered a valuable medicine, has been discovered to have neuroprotective effects. ...
Source: Molecules - September 19, 2018 Category: Chemistry Authors: Xiaobo Meng Weijie Xie Quanfu Xu Tian Liang Xudong Xu Guibo Sun Xiaobo Sun Tags: Article Source Type: research

Featured Review: Mediterranean-style diet for the prevention of cardiovascular disease
In this Q&A we asked the lead author Professor Saverio Stranges from Western University Canada to explain more about the mediterranean diet and its role in preventing cardiovascular disease following the publication of aCochrane Review on this topic. What makes a diet ‘Mediterranean’?Scientific interest in the traditional Mediterranean dietary pattern originated in the 1960s because of the observation that populations in countries of the Mediterranean region, such as Greece and Italy, had lower mortality from cardiovascular disease compared with northern European populations or the US, probably as a result of diff...
Source: Cochrane News and Events - February 27, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

SOD3 overexpression alleviates cerebral ischemia ‐reperfusion injury in rats
ConclusionOur results indicated that MSCs transfected withSOD3 can effectively alleviate cerebral ischemia ‐reperfusion injury in rats.
Source: Molecular Genetics & Genomic Medicine - August 27, 2019 Category: Genetics & Stem Cells Authors: Shuaiqi Sun, Ning Gao, Xiqi Hu, Han Luo, Jun Peng, Ying Xia Tags: ORIGINAL ARTICLE Source Type: research

The Protective and Reparative Role of Colony Stimulating Factors in the Brain with Cerebral Ischemia / Reperfusion Injury
Stroke is a debilitating disease and has the ability to culminate in devastating clinical outcomes. Ischemic stroke followed by reperfusion entrains cerebral ischemia / reperfusion (I/R) injury, which is a complex pathological process and is associated with serious clinical manifestations. Therefore, the development of a robust and effective post-stroke therapy is crucial. Granulocyte colony stimulating factor (GCSF) and erythropoietin (EPO), originally discovered as hematopoietic growth factors, are versatile and have transcended beyond their traditional role of orchestrating the proliferation, differentiation and surviva...
Source: Neuroendocrinology - October 18, 2020 Category: Endocrinology Source Type: research

Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPAR δ for antioxidant action
Free Radic Biol Med. 2022 Jan 27:S0891-5849(22)00033-8. doi: 10.1016/j.freeradbiomed.2022.01.022. Online ahead of print.ABSTRACTCerebral ischemic stroke ranks the second leading cause of death and the third leading cause of disability in lifetime all around the world, urgently necessitating effective therapeutic interventions. Reactive oxygen species (ROS) have been implicated in stroke pathogenesis and peroxisome proliferator-activated receptors (PPARs) are prominent targets for ROS management. Although recent research has shown antioxidant effect of berberine (BBR), little is known regarding its effect upon ROS-PPARs sig...
Source: Free Radical Biology and Medicine - January 30, 2022 Category: Biology Authors: Jia-Wen Shou Xiao-Xiao Li Yun-Sang Tang Bobby Lim-Ho Kong Hoi-Yan Wu Meng-Jie Xiao Chun-Kai Cheung Pang-Chui Shaw Source Type: research