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Transfemoral transcatheter aortic valve replacement in the presence of a mitral prosthesis
Conclusion The current study demonstrates that in patients with severe aortic valve stenosis or regurgitation and mitral valve prosthesis, the implantation of a self-expanding aortic valve via the transfemoral route is safe and feasible, with maintained long-term results.
Source: Journal of Cardiovascular Medicine - November 6, 2019 Category: Cardiology Tags: Research articles: Structural heart intervention Source Type: research

Transcatheter Aortic Valve Implantation in Patients With Pre-Existing Mechanical Mitral Valve Prostheses.
CONCLUSION: TAVI in patients with mechanical MVR is challenging and requires careful preparation and choice of TAVI device. Repositionable and retrievable devices seem to be a safer option. PMID: 31478891 [PubMed - in process]
Source: The Journal of Invasive Cardiology - September 5, 2019 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Comparative Outcomes of Transcarotid and Trans-subclavian Transcatheter Aortic Valve Replacement
ConclusionsThe transcarotid and the trans-subclavian approaches have similar safety and efficacy outcomes. The transcarotid approach had a shorter procedure duration and a trend towards lower fluoroscopy duration and radiation exposure.
Source: The Annals of Thoracic Surgery - July 4, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Comparative Outcomes of Transcarotid and Trans-subclavian Transcatheter Aortic Valve Replacement.
CONCLUSIONS: The transcarotid and the trans-subclavian approaches have similar safety and efficacy outcomes. The transcarotid approach had a shorter procedure duration and a trend towards lower fluoroscopy duration and radiation exposure. PMID: 31279787 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - July 3, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Amer MR, Mosleh W, Joshi S, Mather JF, El-Mallah W, Cheema M, McKay RG Tags: Ann Thorac Surg Source Type: research

A Direct Comparison of Self-Expandable Portico Versus Balloon-Expandable Sapien 3 Devices for Transcatheter Aortic Valve Replacement: A Case-Matched Cohort Study.
CONCLUSIONS: Short-term clinical and hemodynamic outcomes were similar with Portico and Sapien 3 prostheses; no statistically significant differences were observed in mortality and major complication rates. An individually tailored prosthesis choice is suggested. PMID: 31257214 [PubMed - in process]
Source: The Journal of Invasive Cardiology - July 2, 2019 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Transcatheter, sutureless and conventional aortic-valve replacement: a network meta-analysis of 16,432 patients.
Conclusions: In selected patients, minimally invasive surgical interventions including TAVI and SL-AVR for severe AS are viable alternatives to conventional surgery. However, TAVI is associated with increased paravalvular regurgitation, whereas TAVI and SL-AVR are associated with increased conduction disturbances compared to CAVR. PMID: 30863588 [PubMed]
Source: Journal of Thoracic Disease - March 14, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Use of left atrial appendage occlusion among older cardiac surgery patients with preoperative atrial fibrillation: a national cohort study
ConclusionsSubstantial variability in use of S-LAAO exists. In many instances, the procedure is being deferred in the patients that may be poised to benefit the most (i.e., those with increased CHA2DS2-VASc score-defined stroke risk).
Source: Journal of Interventional Cardiac Electrophysiology - February 2, 2019 Category: Cardiology Source Type: research

Five-Year Clinical and Echocardiographic Outcomes from the Nordic Aortic Valve Intervention (NOTION) Randomized Clinical Trial in Lower Surgical Risk Patients.
CONCLUSIONS: These are currently the longest follow-up data comparing TAVR and SAVR in lower risk patients, demonstrating no statistical difference for major clinical outcomes 5 years after TAVR with a self-expanding prosthesis compared to SAVR. Higher rates of prosthetic regurgitation and pacemaker implantation were seen after TAVR. CLINICAL TRIAL REGISTRATION: URL: http://www.ClinicalTrials.gov. Unique identifier: NCT01057173. PMID: 30704298 [PubMed - as supplied by publisher]
Source: Circulation - February 1, 2019 Category: Cardiology Authors: Thyregod HGH, Ihlemann N, Jørgensen TH, Nissen H, Kjeldsen BJ, Petursson P, Chang Y, Franzen OW, Engstrøm T, Clemmensen P, Hansen PB, Andersen LW, Steinbrüchel DA, Olsen PS, Søndergaard L Tags: Circulation Source Type: research

Feasibility and Outcomes of Transcatheter Aortic Valve Implantation Using the Left Axillary Artery as Primary Access Site
ConclusionsThis is the first study reporting outcome after transcatheter aortic valve implantation using the LAA as default access. We conclude that it is highly feasible and safe with low rates of major vascular complications, bleeding, and stroke.Visual Abstract
Source: The Annals of Thoracic Surgery - January 26, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Impact of Discharge Location After Transcatheter Aortic Valve Replacement On 1-Year Outcomes In Women: Results From The WIN-TAVI Registry
ConclusionsIn women undergoing contemporary TAVR, discharge disposition significantly affects 1-year risk of outcomes even after adjustment for recorded baseline differences. This might suggest the necessity of considering additional factors beyond comorbidities in the TAVR decision-making process.
Source: Canadian Journal of Cardiology - December 12, 2018 Category: Cardiology Source Type: research

Clinical outcomes of heart-team-guided treatment decisions in high-risk patients with aortic valve stenosis in a health-economic context with limited resources for transcatheter valve therapies.
CONCLUSIONS: Limited resources for transcatheter valve therapies in Belgium push a significant number of patients to SAVR, while TAVI in even higher risk patients translates into similar outcomes and shorter hospital stay. These findings underscore the need for broadening indications for TAVI, as well as readjustment of the budgetary allocations for hospitals in Belgium. PMID: 30507297 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - December 8, 2018 Category: Cardiology Tags: Acta Cardiol Source Type: research

Outcomes after transcatheter aortic valve replacement in patients with low versus high gradient severe aortic stenosis in the setting of preserved left ventricular ejection fraction
ConclusionPatients with preserved LVEF undergoing TAVR for severe AS with LG, including LG with low SVI, have no significant difference in adverse outcomes when compared to patients with HG.
Source: Journal of Interventional Cardiology - December 5, 2018 Category: Cardiology Authors: Binita Shah, Daniel McDonald, Darien Paone, Gabriel Redel ‐Traub, Umair Jangda, Yu Guo, Muhamed Saric, Robert Donnino, Cezar Staniloae, Tonya Robin, Ricardo Benenstein, Alan Vainrib, Mathew R. Williams Tags: ORIGINAL INVESTIGATION Source Type: research

A versatile transapical device for aortic valvular disease: One-year outcomes of a multicenter study on the J-Valve system.
CONCLUSIONS: Our study provides further evidence on the safety and efficacy of the J-Valve in high-risk patients with AS or AR for surgery. PMID: 30064947 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - July 28, 2018 Category: Cardiology Authors: Tung M, Wang X, Li F, Wang H, Guo Y, Wang C, Wei L, Luo X, Wang X, Wang W Tags: J Cardiol Source Type: research

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