Filtered By:
Drug: Insulin

This page shows you your search results in order of relevance. This is page number 12.

Order by Relevance | Date

Total 38796 results found since Jan 2013.

Apple cider vinegar diet: Does it really work?
Follow me on Twitter @RobShmerling People search for information on a wide variety of health topics in Google and other search engines. That’s no surprise. But I was surprised to learn that “apple cider vinegar weight loss diet” was among the fastest-rising health topic searches for Google in 2017. And then I found out that apple cider vinegar has been used medicinally for centuries! Why the renewed interest? And, more importantly, does it work? What is the apple cider vinegar diet? Apple cider vinegar comes from apples that have been crushed, distilled, and then fermented. It can be consumed in small quantities or t...
Source: Harvard Health Blog - April 25, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Diet and Weight Loss Folk remedies Health Source Type: blogs

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
CONCLUSION: Biomarker panels for frailty would be of high value and better than single markers. Based on our search we would propose a core panel of frailty biomarkers consisting of (1) CXCL10 (C-X-C motif chemokine ligand 10), IL-6 (interleukin 6), CX3CL1 (C-X3-C motif chemokine ligand 1), (2) GDF15 (growth differentiation factor 15), FNDC5 (fibronectin type III domain containing 5), vimentin (VIM), (3) regucalcin (RGN/SMP30), calreticulin, (4) PLAU (plasminogen activator, urokinase), AGT (angiotensinogen), (5) BDNF (brain derived neurotrophic factor), progranulin (PGRN), (6) α-klotho (KL), FGF23 (fibroblast growth facto...
Source: Ageing Research Reviews - July 30, 2018 Category: Genetics & Stem Cells Authors: Cardoso AL, Fernandes A, Aguilar-Pimentel JA, de Angelis MH, Guedes JR, Brito MA, Ortolano S, Pani G, Athanasopoulou S, Gonos ES, Schosserer M, Grillari J, Peterson P, Tuna BG, Dogan S, Meyer A, van Os R, Trendelenburg AU Tags: Ageing Res Rev Source Type: research

Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.
CONCLUSIONS: Evidence concerning the efficacy and safety of glucose-lowering agents in diabetes and CKD is limited. SGLT2 inhibitors and GLP-1 agonists are probably efficacious for glucose-lowering and DPP-4 inhibitors may be efficacious for glucose-lowering. Additionally, SGLT2 inhibitors probably reduce BP, heart failure, and hyperkalaemia but increase genital infections, and slightly increase creatinine. The safety profile for GLP-1 agonists is uncertain. No further conclusions could be made for the other classes of glucose-lowering agents including insulin. More high quality studies are required to help guide therapeut...
Source: Cochrane Database of Systematic Reviews - September 24, 2018 Category: General Medicine Authors: Lo C, Toyama T, Wang Y, Lin J, Hirakawa Y, Jun M, Cass A, Hawley CM, Pilmore H, Badve SV, Perkovic V, Zoungas S Tags: Cochrane Database Syst Rev Source Type: research

Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy
From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy Jens Juul Holst* Department of Biomedical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Researchers have been looking for insulin-stimulating factors for more than 100 years, and in the 1960ties it was definitively proven that the gastrointestinal tract releases important insulinotropic factors upon oral glucose intake, so-called incretin hormones. The first significant factor identified was the duodenal glucose-dependent insulinotropic polypeptide, GIP, wh...
Source: Frontiers in Endocrinology - April 25, 2019 Category: Endocrinology Source Type: research

A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Health-Related Complications of Acromegaly —Risk of Malignant Neoplasms
Conclusions On the basis of the described studies the risk of malignant neoplasms seems to be increased in patients with acromegaly. The strongest evidence is available for thyroid and colon cancer. Higher incidence of these two cancers was confirmed by numerous studies and at least two meta-analyses performed by different authors. Relatively strong evidence is available for breast cancer, increased risk was described by few studies and confirmed by meta-analysis performed by Dal et al. (15). Risk of neuroendocrine neoplasms seems to be increased in patients with MEN1 syndrome (6, 18). The increased prevalence of other ma...
Source: Frontiers in Endocrinology - April 29, 2019 Category: Endocrinology Source Type: research

The role of zinc and copper in insulin resistance and diabetes mellitus.
Abstract The prevalence of type 2 diabetes mellitus (T2DM) is internationally ever-growing. Therefore, prevention, diagnostics, and control of insulin resistance and T2DM are of increasing importance. It has been suggested that mechanisms leading to insulin resistance and diabetes and its complications include high intake of refined and energy-rich food, which is presumed to be accompanied by suboptimal intake of trace elements, such as zinc (Zn), selenium (Se), chromium (Cr), and copper (Cu), which are essential and crucial for various biological processes. The purpose of this review is to highlight the role of Z...
Source: Current Medicinal Chemistry - September 1, 2019 Category: Chemistry Authors: Bjørklund G, Dadar M, Pivina L, Doşa MD, Semenova Y, Aaseth J Tags: Curr Med Chem Source Type: research

Vitamin D Supplementation during Pregnancy: An Evidence Analysis Center Systematic Review and Meta-Analysis
ConclusionsResults show vitamin D supplementation during pregnancy improves maternal and infant 25(OH)D concentrations and may play a role in maternal insulin resistance and fetal growth. To further inform practice and policies on the amount of vitamin D, which supports a healthy pregnancy, high quality dose-response randomized clinical trials, which assess pregnancy-specific 25(OH)D thresholds, and appropriately powered clinical outcomes are needed.
Source: Journal of the Academy of Nutrition and Dietetics - October 26, 2019 Category: Nutrition Source Type: research

Cardio-metabolic risk factors among young infertile women: a systematic review and meta-analysis.
CONCLUSIONS: Infertile women have a higher level of cardio-metabolic risk factors compared to fertile women. This finding has clinical implications for infertile women in general, and those attempting to conceive through medically assisted reproduction. PMID: 32048421 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - February 11, 2020 Category: OBGYN Authors: Mulder CL, Lassi ZS, Grieger JA, Ali A, Jankovic-Karasoulos T, Roberts CT, Andraweera PH Tags: BJOG Source Type: research

Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Probiotics, prebiotics, and synbiotics supplementation in prediabetes: protocol for a systematic review and meta-analysis
Conclusion: The findings of this study will provide the best available evidence for probiotics, prebiotics, and synbiotics in the treatment of prediabetes, and provide a strong basis for clinical treatment.
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Fight Aging! Newsletter, May 11th 2020
In this study, we found that older nematodes have higher ROS levels. Interestingly, after hydrogen treatment, the ROS levels were significantly decreased, and hydrogen could significantly extend the lifespans of the N2, sod-3 and sod-5 mutant strains, by approximately 22.7%, 9.5%, and 8.7%, respectively. In addition, aging is regulated by a variety of pathways, such as the insulin signaling pathway, the rapamycin target signaling pathway, and the caloric restriction pathway. However, our results showed that the lifespans of the daf-2 and daf-16 strains, in which these pathways are upregulated, were not affected afte...
Source: Fight Aging! - May 10, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Efficacy of vitamin D supplement in children with nonalcoholic fatty liver disease: A protocol for systematic review and meta-analysis
Conclusion: This systematic review and meta-analysis will provide evidence to judge whether vitamin D supplementation is an effective intervention for children with NAFLD. Registration number: INPLASY202050049.
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
CONCLUSIONS: While the effects on HbA1c were comparable, treatment with insulin glargine and insulin detemir resulted in fewer participants experiencing hypoglycaemia when compared with NPH insulin. Treatment with insulin detemir also reduced the incidence of serious hypoglycaemia. However, serious hypoglycaemic events were rare and the absolute risk reducing effect was low. Approximately one in 100 people treated with insulin detemir instead of NPH insulin benefited. In the studies, low blood glucose and HbA1c targets, corresponding to near normal or even non-diabetic blood glucose levels, were set. Therefore, results fro...
Source: Cochrane Database of Systematic Reviews - November 9, 2020 Category: General Medicine Authors: Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K Tags: Cochrane Database Syst Rev Source Type: research