Fight Aging! Newsletter, January 28th 2019

In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia https://www.fightaging.org/archives/2019/01/greater-modest-activity-in-late-life-correlates-with-lower-incidence-of-dementia/ Since the advent of low-cost, small accelerometers of the sort found in every modern mobile phone, it has been possible to gather much better data on the degree to which people are active or inactive. One of the findings that has emerged in epidemiological studies of exercise in older people is that even modest levels of activity appear to have a sizable correlation with health. This means puttering around in the kitchen or the garden, walking around the house little more, and the like. In the bigger picture, it is very reasonable to believe that exercise causes better health; this is proven in animal studies, even though the best that most human studies can do is to show an association. Exercise, like any treatment, has a dose...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Authors: Li T, Han J, Jia L, Hu X, Chen L, Wang Y Abstract A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis. mTOR increases the PKM2:MFN2 interaction by p...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
In conclusion, CD133 promoted the upregulation of CSC/TSC-related genes in glioma cells, while enhancing the neurosphere-forming ability and in-vivo oncogenicity. PMID: 30891998 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Broser® (bromelain, escin and selenium), oral nutraceutical, monotherapy in patients with inflammatory otorhinolaryngological disorders. J Biol Regul Homeost Agents. 2019 Mar 20;33(2): Authors: Cupido GF, Gelardi M, La Mantia I, Aragona SE, Ciprandi G, Italian Study Group on Inflammatory Otorhinolaryngological Disorders. Aielli Federica, Albanese Gianluca, Allosso Giuseppe, Amadori Maurizio, Antoniacomi Giovanni, Asprea Francesco, Auletta Pasquale, Azzaro Raffaele, Balduzzi Attilio, Bellini Vito, Benedetto Domenico, Berardi Carlo, Bernardi Rosanna, Bianchi Alessandro, Bordonaro Carla, Brindisi Annamaria, B...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Conclusions: tTGIgA were increasingly tested, while the rate of positive results decreased in recent years, possibly reflecting the impact of current alimentary trends on clinical practice. Associated autoimmune disease was frequently found in CD. High levels of tTGIgA accurately predicted CD diagnosis. WA was rarely investigated and deserves more attention, in particular in children with atopic background. WA does not seem to be associated with CD.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: Our data suggest that IFN- β treatment alters the TLR-dependent immune response of PBMCs from MS patients. This may contribute to the beneficial effects of IFN-β treatment.Neuroimmunomodulation
Source: Neuroimmunomodulation - Category: Allergy & Immunology Source Type: research
Conclusion: Substitution of parenteral thiamine in individuals with suspected WE is a well-established treatment regimen. However, suggestions according to guidelines vary widely. Furthermore, hardly any evidence-based recommendations exist on a more general use of thiamine as a preventative intervention in individuals with AUD. Further research is of utmost importance to raise awareness for this potentially undervalued problem.Eur Addict Res 2019;25:103 –110
Source: European Addiction Research - Category: Addiction Source Type: research
Conclusions: Lifetime cannabis use is associated with better working memory and processing speed and worse real-world functioning in the area of socially useful activities in patients with schizophrenia-related disorders. Clinicians should, therefore, be aware of it to provide patient-centred care in their daily clinical practice.Eur Addict Res 2019;25:111 –118
Source: European Addiction Research - Category: Addiction Source Type: research
The objective of this paper is to analyse how narratives targeting ambitions and self-realisation in work life are expressed by individuals with HFA in relation to the citizen-worker discourse. This ethnographic study comprises 26 qualitative interview narratives by 11 participants with HFA. Findings indicate that the participants have developed a strong citizen-worker identity. The will is an essential point of gravity, expressed through notions of individual meaningfulness and ambitions of being perceived as resources in any vocational context. Barriers to these ambitions are experienced as personally counteractive suppo...
Source: ALTER - European Journal of Disability Research - Category: Disability Source Type: research
Publication date: Available online 20 March 2019Source: Stem Cell ResearchAuthor(s): Berta de la Cerda, Andrea Díez-Lloret, Beatriz Ponte, Laura Vallés-Sáiz, Sofia M. Calado, Eduardo Rodríguez-Bocanegra, Ana B. Garcia-Delgado, Marina Moya-Molina, Shom S. Bhattacharya, Francisco J. Díaz-CorralesAbstractPRPF31 gene codes for a ubiquitously expressed splicing factor but mutations affect exclusively the retina, producing the progressive death of photoreceptor cells. We have identified a novel PRPF31 mutation in a patient with autosomal dominant retinitis pigmentosa. A blood sample was obtaine...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
This article is the first systematic review of the effects of biosynthesized nanoparticles on both malaria parasites (Plasmodium spp.) and relevant vectors.Graphical Abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
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